Bioactive Compound Details
| Compound ID: | B716337 |
| Source ID: | CHEMBL1289926 |
| Source Type: | Small molecule |
| Compound Name: | AXITINIB |
| Synonyms: | AG-013736|AG-13736|Axitinib|Axitinib|Axitinib|Axitinib|Axitinib|Axitinib|Axitinib|Axitinib|Axitinib|Inlyta|NSC-757441 |
| Molecular Formula: | C22H18N4OS |
| SMILES: | CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T50 | Interferon-induced helicase C domain-containing protein 1 | IFIH1 | Hydrolase | Q9BYX4 | IFIH1_HUMAN | Details | |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T36 | Mitochondrial glycerol-3-phosphate dehydrogenase | GPD2 | INHIBITOR | Oxidoreductase | P43304 | GPD2_HUMAN | Details |
| T21 | Uncharacterized aarF domain-containing protein kinase 4 | COQ8B | Target is a single protein chain | Q96D53 | COQ8B_HUMAN | Details | |
| T16 | Phospholipase C-gamma-2 | PLCG2 | Hydrolase | P16885 | PLCG2_HUMAN | Details | |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T30 | TP53-regulating kinase | TP53RK | Target is a single protein chain | Q96S44 | TP53RK_HUMAN | Details | |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T07 | Potassium channel, inwardly rectifying, subfamily J, member 11 | KCNJ11 | OPENER | Target is a single protein chain | Q14654 | KCNJ11_HUMAN | Details |
| T06 | Sulfonylurea receptor 1 | ABCC8 | Target is a single protein chain | Q09428 | ABCC8_HUMAN | Details |