Research Articles
Research articles concerning CKD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in CKDdb are presented with knowledge graphs.
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231 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00101 | 17623760 | J Clin Endocrinol Metab | Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals. | 2007 | Details |
| A00102 | 17652184 | Mol Endocrinol | Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. | 2008 | Details |
| A00103 | 17671651 | J Clin Invest | Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. | 2007 | Details |
| A00104 | 17726085 | J Clin Endocrinol Metab | Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children. | 2008 | Details |
| A00105 | 17906635 | Nat Med | Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. | 2007 | Details |
| A00106 | 18008060 | Diabetologia | The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. | 2008 | Details |
| A00107 | 18025464 | Proc Natl Acad Sci U S A | Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes. | 2008 | Details |
| A00108 | 18097733 | J Hum Genet | Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects. | 2008 | Details |
| A00109 | 18231124 | Eur J Hum Genet | HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort. | 2008 | Details |
| A00110 | 18323454 | Science | Hepatic glucose sensing via the CREB coactivator CRTC2. | 2008 | Details |
| A00111 | 18364377 | J Clin Endocrinol Metab | The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects. | 2008 | Details |
| A00112 | 18477659 | J Clin Endocrinol Metab | Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. | 2008 | Details |
| A00113 | 18596924 | J Clin Invest | Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations. | 2008 | Details |
| A00114 | 18602895 | Biochem Biophys Res Commun | Allele-specific targeting of hsa-miR-657 to human IGF2R creates a potential mechanism underlying the association of ACAA-insertion/deletion polymorphism with type 2 diabetes. | 2008 | Details |
| A00115 | 18711366 | Nat Genet | SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. | 2009 | Details |
| A00116 | 18711367 | Nat Genet | Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. | 2009 | Details |
| A00117 | 1890161 | J Clin Endocrinol Metab | A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman. | 1991 | Details |
| A00118 | 18952314 | Trends Genet | Type 2 diabetes: new genes, new understanding. | 2009 | Details |
| A00119 | 19020323 | N Engl J Med | Genotype score in addition to common risk factors for prediction of type 2 diabetes. | 2008 | Details |
| A00120 | 19020324 | N Engl J Med | Clinical risk factors, DNA variants, and the development of type 2 diabetes. | 2008 | Details |
| A00121 | 19164855 | J Clin Invest | Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. | 2009 | Details |
| A00122 | 19602480 | Hum Mol Genet | Tissue-specific alternative splicing of TCF7L2. | 2010 | Details |
| A00123 | 1963473 | Mol Endocrinol | Functional properties of a naturally occurring Trp1200----Ser1200 mutation of the insulin receptor. | 1991 | Details |
| A00124 | 19639018 | Nat Rev Nephrol | HNF1B-related diabetes triggered by renal transplantation. | 2009 | Details |
| A00125 | 19657112 | N Engl J Med | Sex hormone-binding globulin and risk of type 2 diabetes in women and men. | 2009 | Details |
| A00126 | 19689793 | BMC Med Genomics | MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes. | 2009 | Details |
| A00127 | 19933169 | Hum Mol Genet | Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. | 2010 | Details |
| A00128 | 20016592 | Nature | Parental origin of sequence variants associated with complex diseases. | 2010 | Details |
| A00129 | 20085713 | Am J Hum Genet | Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. | 2010 | Details |
| A00130 | 20118932 | Nat Genet | A map of open chromatin in human pancreatic islets. | 2010 | Details |
| A00131 | 20353613 | Genome Med | Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes. | 2011 | Details |
| A00132 | 20360734 | Nature | Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. | 2010 | Details |
| A00133 | 20427569 | Mol Biol Cell | Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complex. | 2010 | Details |
| A00134 | 20574426 | J Hum Genet | The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population. | 2011 | Details |
| A00135 | 20651284 | Circ Res | Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. | 2010 | Details |
| A00136 | 21118154 | Biochem J | LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice. | 2011 | Details |
| A00137 | 21186350 | Nat Genet | Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. | 2011 | Details |
| A00138 | 21364139 | JAMA | Functional variants of the HMGA1 gene and type 2 diabetes mellitus. | 2011 | Details |
| A00139 | 21536946 | Diabetes | Diazoxide-unresponsive congenital hyperinsulinism in children with dominant mutations of the β-cell sulfonylurea receptor SUR1. | 2011 | Details |
| A00140 | 21673050 | Genome Res | Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. | 2012 | Details |
| A00141 | 22286214 | Nat Genet | Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. | 2012 | Details |
| A00142 | 22929189 | Orphanet J Rare Dis | Inherited cobalamin malabsorption. Mutations in three genes reveal functional and ethnic patterns. | 2013 | Details |
| A00143 | 23275527 | J Clin Endocrinol Metab | Genotype and phenotype correlations in 417 children with congenital hyperinsulinism. | 2013 | Details |
| A00144 | 24193408 | Pflugers Arch | Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin. | 2015 | Details |
| A00145 | 24390345 | Nature | Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. | 2014 | Details |
| A00146 | 24463454 | J Clin Invest | Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. | 2014 | Details |
| A00147 | 24518126 | Am J Kidney Dis | Chronic kidney pain in autosomal dominant polycystic kidney disease: a case report of successful treatment by catheter-based renal denervation. | 2014 | Details |
| A00148 | 24584071 | Nat Genet | Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. | 2014 | Details |
| A00149 | 24897035 | Kidney Int | The HNF1B score is a simple tool to select patients for HNF1B gene analysis. | 2015 | Details |
| A00150 | 24904092 | J Am Soc Nephrol | Imaging classification of autosomal dominant polycystic kidney disease: a simple model for selecting patients for clinical trials. | 2015 | Details |
| A00151 | 24994926 | J Am Soc Nephrol | Tolvaptan plus pasireotide shows enhanced efficacy in a PKD1 model. | 2015 | Details |
| A00152 | 25349199 | J Am Soc Nephrol | A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome. | 2015 | Details |
| A00153 | 25536396 | Nat Rev Nephrol | HNF1B-associated renal and extra-renal disease-an expanding clinical spectrum. | 2015 | Details |
| A00154 | 25646624 | PLoS One | An efficient and comprehensive strategy for genetic diagnostics of polycystic kidney disease. | 2016 | Details |
| A00155 | 25741167 | World J Gastroenterol | Hepatic phenotypes of HNF1B gene mutations: a case of neonatal cholestasis requiring portoenterostomy and literature review. | 2015 | Details |
| A00156 | 25786098 | Kidney Int | Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. | 2016 | Details |
| A00157 | 25894829 | Nat Med | Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. | 2015 | Details |
| A00158 | 26150605 | J Am Soc Nephrol | The PROPKD Score: A New Algorithm to Predict Renal Survival in Autosomal Dominant Polycystic Kidney Disease. | 2016 | Details |
| A00159 | 26340261 | Am J Nephrol | Hypomagnesemia as First Clinical Manifestation of ADTKD-HNF1B: A Case Series and Literature Review. | 2016 | Details |
| A00160 | 26551672 | Nat Genet | Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. | 2016 | Details |
| A00161 | 26912555 | Clin J Am Soc Nephrol | Effect of Sirolimus on Disease Progression in Patients with Autosomal Dominant Polycystic Kidney Disease and CKD Stages 3b-4. | 2017 | Details |
| A00162 | 2695375 | Diabetes | Distribution of in vivo insulin action in Pima Indians as mixture of three normal distributions. | 1990 | Details |
| A00163 | 27188453 | Eur J Endocrinol | Clinical and genetic characterization of congenital hyperinsulinism in Spain. | 2017 | Details |
| A00164 | 27398621 | Nature | The genetic architecture of type 2 diabetes. | 2016 | Details |
| A00165 | 27484667 | Nephrol Dial Transplant | Prognostic enrichment design in clinical trials for autosomal dominant polycystic kidney disease: the HALT-PKD clinical trial. | 2018 | Details |
| A00166 | 27615128 | Diabetes Obes Metab | The role of hepatocyte nuclear factor 1β in disease and development. | 2017 | Details |
| A00167 | 27896077 | Mol Genet Metab Rep | Sequencing analysis of insulin receptor defects and detection of two novel mutations in <i>INSR</i> gene. | 2020 | Details |
| A00168 | 27908292 | Orphanet J Rare Dis | Conservatively treated Congenital Hyperinsulinism (CHI) due to K-ATP channel gene mutations: reducing severity over time. | 2017 | Details |
| A00169 | 28132686 | Am J Hum Genet | Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice. | 2017 | Details |
| A00170 | 28215227 | Adv Protein Chem Struct Biol | Elucidating the Mutational Landscape in Hepatocyte Nuclear Factor 1β (HNF1B) by Computational Approach. | 2017 | Details |
| A00171 | 28838955 | J Am Soc Nephrol | Bosutinib versus Placebo for Autosomal Dominant Polycystic Kidney Disease. | 2017 | Details |
| A00172 | 29361385 | J Formos Med Assoc | Mutation screening of INS and KCNJ11 genes in Taiwanese children with type 1B diabetic onset before the age of 5 years. | 2018 | Details |
| A00173 | 29395486 | Am J Kidney Dis | The Value of Genetic Testing in Polycystic Kidney Diseases Illustrated by a Family With PKD2 and COL4A1 Mutations. | 2019 | Details |
| A00174 | 29471960 | Nefrologia (Engl Ed) | Overview of autosomal dominant polycystic kidney disease in the south of Spain. | 2018 | Details |
| A00175 | 29674338 | Clin J Am Soc Nephrol | Prevalence of Hypertension in Children with Early-Stage ADPKD. | 2019 | Details |
| A00176 | 29751826 | BMC Med Genet | Possible association between ABCC8 C49620T polymorphism and type 2 diabetes in a Nigerian population. | 2019 | Details |
| A00177 | 30422235 | JAMA | Effect of Lanreotide on Kidney Function in Patients With Autosomal Dominant Polycystic Kidney Disease: The DIPAK 1 Randomized Clinical Trial. | 2018 | Details |
| A00178 | 30927425 | Hum Reprod | Factors influencing the clinical outcome of preimplantation genetic testing for polycystic kidney disease. | 2020 | Details |
| A00179 | 30951521 | PLoS Med | Octreotide-LAR in later-stage autosomal dominant polycystic kidney disease (ALADIN 2): A randomized, double-blind, placebo-controlled, multicenter trial. | 2019 | Details |
| A00180 | 31118516 | Nature | Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. | 2019 | Details |
| A00181 | 31676859 | Nat Genet | Loss of ZnT8 function protects against diabetes by enhanced insulin secretion. | 2020 | Details |
| A00182 | 31740684 | Sci Rep | Genetic Characteristics of Korean Patients with Autosomal Dominant Polycystic Kidney Disease by Targeted Exome Sequencing. | 2020 | Details |
| A00183 | 32398770 | Genet Med | Matching clinical and genetic diagnoses in autosomal dominant polycystic kidney disease reveals novel phenocopies and potential candidate genes. | 2021 | Details |
| A00184 | 32631624 | Kidney Int | Clinical spectrum, prognosis and estimated prevalence of DNAJB11-kidney disease. | 2021 | Details |
| A00185 | 32634120 | JCI Insight | The value of genotypic and imaging information to predict functional and structural outcomes in ADPKD. | 2021 | Details |
| A00186 | 32939031 | Genet Med | Clinical impact of genomic testing in patients with suspected monogenic kidney disease. | 2021 | Details |
| A00187 | 33097957 | Nephrol Dial Transplant | Mutations in transcription factor CP2-like 1 may cause a novel syndrome with distal renal tubulopathy in humans. | 2021 | Details |
| A00188 | 33141305 | Clin Exp Nephrol | Effect of tolvaptan on renal involvement in patients with autosomal dominant polycystic kidney disease according to different gene mutations. | 2021 | Details |
| A00189 | 33164752 | Elife | The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus. | 2021 | Details |
| A00190 | 33434175 | Endocrinol Diabetes Metab Case Rep | A novel splice-site mutation of the HNF1B gene in a family with maturity onset diabetes of the young type 5 (MODY5). | 2024 | Details |
| A00191 | 33853507 | Nucleosides Nucleotides Nucleic Acids | Association of common genetic variants of <i>KCNJ11</i> gene with the risk of type 2 diabetes mellitus. | 2024 | Details |
| A00192 | 34145744 | Am J Med Genet A | Homozygous WNT9B variants in two families with bilateral renal agenesis/hypoplasia/dysplasia. | 2022 | Details |
| A00193 | 36646975 | Pediatr Nephrol | Dual diagnosis of autosomal dominant polycystic kidney disease and sickle cell disease in a teenage male. | 2023 | Details |
| A00194 | 39660790 | J Med Econ | Cost-effectiveness analysis of radiofrequency renal denervation for uncontrolled hypertension in Canada. | 2024 | Details |
| A00195 | 39684653 | Int J Mol Sci | Pharmacological Nephroprotection in Chronic Kidney Disease Patients with Type 2 Diabetes Mellitus-Clinical Practice Position Statement of the Polish Society of Nephrology. | 2024 | Details |
| A00196 | 39704168 | JCI Insight | Fasting substrates predict chronic kidney disease progression in CREDENCE trial patients with type 2 diabetes. | 2024 | Details |
| A00197 | 39731488 | Malays J Pathol | MACB CKD Task Force updated recommendations for reporting estimated glomerular filtration rate and albuminuria in adults. | 2024 | Details |
| A00198 | 39746795 | Ren Fail | Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production. | 2025 | Details |
| A00199 | 39783822 | J Med Econ | Cost-effectiveness of finerenone therapy for patients with chronic kidney disease and type 2 diabetes in England & Wales: results of the FINE-CKD model. | 2025 | Details |
| A00200 | 39804512 | Langenbecks Arch Surg | A hypocaloric protein-rich diet before metabolic surgery improves liver function in patients with obesity and diabetes : A secondary analysis of a randomized clinical trial. | 2025 | Details |