Bioactive Compound Details
| Compound ID: | B276734 |
| Source ID: | CHEMBL1336 |
| Source Type: | Small molecule |
| Compound Name: | SORAFENIB |
| Synonyms: | Sorafenib|BAY 43-9006|BAY-43-9006|Nexavar|Sorafenib|Sorafenib|Sorafenib|Sorafenib|Sorafenib|Sorafenib |
| Molecular Formula: | C21H16ClF3N4O3 |
| SMILES: | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T20 | Hepatocyte nuclear factor 4-alpha | HNF4A | ACTIVATOR | Target is a single protein chain | P41235 | HNF4A_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T50 | Interferon-induced helicase C domain-containing protein 1 | IFIH1 | Hydrolase | Q9BYX4 | IFIH1_HUMAN | Details | |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T21 | Uncharacterized aarF domain-containing protein kinase 4 | COQ8B | Target is a single protein chain | Q96D53 | COQ8B_HUMAN | Details | |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T30 | TP53-regulating kinase | TP53RK | Target is a single protein chain | Q96S44 | TP53RK_HUMAN | Details | |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T21 | Uncharacterized aarF domain-containing protein kinase 4 | COQ8B | Target is a single protein chain | Q96D53 | COQ8B_HUMAN | Details | |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T28 | Interleukin-6 | IL6 | ANTAGONIST; INHIBITOR; BINDING AGENT | Target is a single protein chain | P05231 | IL6_HUMAN | Details |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T21 | Uncharacterized aarF domain-containing protein kinase 4 | COQ8B | Target is a single protein chain | Q96D53 | COQ8B_HUMAN | Details | |
| T20 | Hepatocyte nuclear factor 4-alpha | HNF4A | ACTIVATOR | Target is a single protein chain | P41235 | HNF4A_HUMAN | Details |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |