Bioactive Compound Details
| Compound ID: | B602271 |
| Source ID: | CHEMBL601719 |
| Source Type: | Small molecule |
| Compound Name: | CRIZOTINIB |
| Synonyms: | PF-2341066|Crizotinib|Crizotinib|Crizotinib|Crizotinib|Crizotinib|Crizotinib|Crizotinib|Crizotinib|NSC-756645|PF-02341066|Pf-2341066|Xalkori |
| Molecular Formula: | C21H22Cl2FN5O |
| SMILES: | C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl |
| Molecular Species: | BASE |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T07 | Potassium channel, inwardly rectifying, subfamily J, member 11 | KCNJ11 | OPENER | Target is a single protein chain | Q14654 | KCNJ11_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T20 | Hepatocyte nuclear factor 4-alpha | HNF4A | ACTIVATOR | Target is a single protein chain | P41235 | HNF4A_HUMAN | Details |
| T50 | Interferon-induced helicase C domain-containing protein 1 | IFIH1 | Hydrolase | Q9BYX4 | IFIH1_HUMAN | Details | |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T21 | Uncharacterized aarF domain-containing protein kinase 4 | COQ8B | Target is a single protein chain | Q96D53 | COQ8B_HUMAN | Details | |
| T50 | Interferon-induced helicase C domain-containing protein 1 | IFIH1 | Hydrolase | Q9BYX4 | IFIH1_HUMAN | Details | |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T30 | TP53-regulating kinase | TP53RK | Target is a single protein chain | Q96S44 | TP53RK_HUMAN | Details | |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T36 | Mitochondrial glycerol-3-phosphate dehydrogenase | GPD2 | INHIBITOR | Oxidoreductase | P43304 | GPD2_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T28 | Interleukin-6 | IL6 | ANTAGONIST; INHIBITOR; BINDING AGENT | Target is a single protein chain | P05231 | IL6_HUMAN | Details |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |