CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C00801 | BRD-K76239644 | BMS-690514 | EGFR|ERBB2|FLT3|KDR | EGFR inhibitor; VEGFR inhibitor | Details | |
| C00802 | BRD-K49555808 | BMS-707035 | HIV integrase inhibitor | Details | ||
| C00803 | BRD-K13049116 | BMS-754807 | AKT1|IGF1R | IGF-1 inhibitor | Details | |
| C00804 | BRD-K40738845 | BMS-777607 | AXL|MERTK|MET|MST1R|TYRO3 | AXL kinase inhibitor; c-Met inhibitor; FLT3 inhibitor; hepatocyte growth factor receptor inhibitor; macrophage migration inhibiting factor inhibitor; tyrosine kinase inhibitor | Details | |
| C00805 | BRD-K55773932 | BMS-806 | HIV attachment inhibitor | Details | ||
| C00806 | BRD-K81026553 | BMS-817378 | KDR|MET | c-Met inhibitor; VEGFR inhibitor | Details | |
| C00807 | BRD-K33245965 | BMS-833923 | SMO | smoothened receptor antagonist | Details | |
| C00808 | BRD-K12511835 | BMS-863233 | CDC7|PIM1 | CDC inhibitor | Details | |
| C00809 | BRD-K55781385 | BMS-927711 | CALCA | calcitonin antagonist | Details | |
| C00810 | BRD-K22316123 | BMS-983970 | notch signaling inhibitor | Details | ||
| C00811 | BRD-K23952234 | BMS-986020 | LPAR1 | lysophosphatidic acid receptor antagonist | Details | |
| C00812 | BRD-A15435692 | BMY-14802 | HTR1A | sigma receptor antagonist | Details | |
| C00813 | BRD-K84895041 | BMY-45778 | PTGIR | IP1 prostacyclin receptor agonist | Details | |
| C00814 | BRD-K31054881 | BMY-7378 | ADRA1A|ADRA1B|ADRA1D|HTR1A | adrenergic receptor antagonist; serotonin receptor antagonist | Details | |
| C00815 | BRD-K20468903 | BNC105 | tubulin polymerization inhibitor | Details | ||
| C00816 | BRD-A55484088 | BNTX | OPRD1|OPRK1|OPRM1 | opioid receptor antagonist | Details | |
| C00817 | BRD-A09735281 | boceprevir | CMA1|CTSA|CTSF|CTSK|CTSL|CTSS | HCV inhibitor | Details | |
| C00818 | BRD-K34149328 | bonaphthone | Details | |||
| C00819 | BRD-A07563059 | bopindolol | ADRB1|ADRB2|ADRB3|HTR1A|HTR1B | adrenergic receptor antagonist | Details | |
| C00820 | BRD-A41385909 | bornyl-acetate | Details | |||
| C00821 | BRD-K50122911 | boronophenylalanine | Details | |||
| C00822 | BRD-K88510285 | bortezomib | PSMA1|PSMA2|PSMA3|PSMA4|PSMA5|PSMA6|PSMA7|PSMA8|PSMB1|PSMB10|PSMB11|PSMB2|PSMB3|PSMB4|PSMB5|PSMB6|PSMB7|PSMB8|PSMB9|PSMD1|PSMD2|RELA | NFkB pathway inhibitor; proteasome inhibitor | Details | |
| C00823 | BRD-K74763371 | bosentan | EDNRA|EDNRB | endothelin receptor antagonist | Details | |
| C00824 | BRD-K99964838 | bosutinib | ABL1|BCR|CAMK1D|CAMK2G|CDK2|FRK|FYN|HCK|LYN|MAP2K1|MAP2K2|MAP3K2|MAP4K5|SRC|STK10|STK24|STK4|TNK2|TXK | Abl kinase inhibitor; Bcr-Abl kinase inhibitor; src inhibitor | Details | |
| C00825 | BRD-K45479396 | BP-554 | HTR1A | serotonin receptor agonist | Details | |
| C00826 | BRD-K17378184 | BP-897 | ADRA1A|ADRA1D|ADRA2A|DRD1|DRD2|DRD3|DRD4|HTR1A|HTR2B | dopamine receptor agonist | Details | |
| C00827 | BRD-A59961917 | BQ-123 | EDNRA | endothelin receptor antagonist | Details | |
| C00828 | BRD-K02490038 | BQ-788 | EDNRB | endothelin receptor antagonist | Details | |
| C00829 | BRD-A40257118 | BQU57 | RALA|RALB | Ras GTPase inhibitor | Details | |
| C00830 | BRD-K15107389 | BRD-7389 | RPS6KA1|RPS6KA2|RPS6KA3 | ribosomal protein inhibitor | Details | |
| C00831 | BRD-K89329876 | BRD-9876 | KIF11 | kinesin inhibitor | Details | |
| C00832 | BRD-K72264770 | BRD4770 | EHMT2 | histone lysine methyltransferase inhibitor | Details | |
| C00833 | BRD-K77841042 | brefeldin-a | ARF1|CYTH2 | protein synthesis inhibitor | Details | |
| C00834 | BRD-K06328344 | bremelanotide | MC1R|MC2R|MC3R|MC4R|MC5R | melanocortin receptor agonist | Details | |
| C00835 | BRD-K96123349 | brequinar | DHODH | dihydroorotate dehydrogenase inhibitor | Details | |
| C00836 | BRD-K96936751 | bretazenil | GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6 | GABA benzodiazepine site receptor partial agonist | Details | |
| C00837 | BRD-K49669424 | bretylium | ATP1A1 | norepinephrine inhibitor | Details | |
| C00838 | BRD-K00911143 | brexpiprazole | DRD2 | dopamine receptor partial agonist | Details | |
| C00839 | BRD-K05531427 | briciclib | CCND1 | cyclin D inhibitor | Details | |
| C00840 | BRD-K56981171 | brigatinib | ALK|EGFR | ALK tyrosine kinase receptor inhibitor; EGFR inhibitor | Details | |
| C00841 | BRD-K60348325 | brilliant-green | Details | |||
| C00842 | BRD-K68264559 | brimonidine | ADRA2A|ADRA2B|ADRA2C | adrenergic receptor agonist | Details | |
| C00843 | BRD-K74913225 | brinzolamide | CA1|CA12|CA14|CA2|CA4|CA5A|CA7 | carbonic anhydrase inhibitor | Details | |
| C00844 | BRD-K28428262 | brivanib | CYP3A4|FGFR1|FLT1|KCNH2|KDR | FGFR inhibitor; VEGFR inhibitor | Details | |
| C00845 | BRD-K57187269 | brivanib-alaninate | FGFR3 | FGFR inhibitor; VEGFR inhibitor | Details | |
| C00846 | BRD-K00634421 | brivaracetam | SV2A | voltage-gated sodium channel blocker | Details | |
| C00847 | BRD-A63675168 | brivudine | DNA directed DNA polymerase inhibitor | Details | ||
| C00848 | BRD-A51829654 | BRL-15572 | HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR6 | serotonin receptor antagonist | Details | |
| C00849 | BRD-A57806482 | BRL-26314 | LPL | cholesterol inhibitor | Details | |
| C00850 | BRD-K07507905 | BRL-37344 | ADRB1|ADRB2|ADRB3 | adrenergic receptor agonist | Details | |
| C00851 | BRD-A67949680 | BRL-44408 | ADRA2A|ADRA2B|ADRA2C | adrenergic receptor antagonist | Details | |
| C00852 | BRD-K84266862 | BRL-50481 | PDE7A|PDE7B | phosphodiesterase inhibitor | Details | |
| C00853 | BRD-A37347161 | BRL-52537 | OPRK1 | opioid receptor agonist | Details | |
| C00854 | BRD-K17868609 | BRL-54443 | HTR1E|HTR1F | serotonin receptor agonist | Details | |
| C00855 | BRD-K76021681 | brolitene | RYR1 | muscle relaxant | Details | |
| C00856 | BRD-K86358349 | bromantan | dopamine reuptake inhibitor; serotonin reuptake inhibitor | Details | ||
| C00857 | BRD-K17874929 | bromebric-acid | purine antagonist; DNA synthesis inhibitor | Details | ||
| C00858 | BRD-K47679368 | bromfenac | PTGS1|PTGS2 | cyclooxygenase inhibitor | Details | |
| C00859 | BRD-K47631482 | bromhexine | mucolytic agent | Details | ||
| C00860 | BRD-K50490982 | bromindione | anticoagulant | Details | ||
| C00861 | BRD-K14496212 | bromocriptine | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|DRD1|DRD2|DRD3|DRD4|DRD5|HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C|HTR6|HTR7 | dopamine receptor agonist | Details | |
| C00862 | BRD-K73642618 | bromopride | DRD2 | dopamine receptor antagonist | Details | |
| C00863 | BRD-K44665581 | bromosporine | bromodomain inhibitor | Details | ||
| C00864 | BRD-K78643075 | bromperidol | DRD2 | dopamine receptor antagonist | Details | |
| C00865 | BRD-A68723818 | brompheniramine | CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|HRH1 | histamine receptor antagonist | Details | |
| C00866 | BRD-K33457401 | bronopol | Details | |||
| C00867 | BRD-K17500877 | bropirimine | interferon inducer | Details | ||
| C00868 | BRD-K36222532 | broxaldine | Details | |||
| C00869 | BRD-A08316590 | broxaterol | ADRB2 | adrenergic receptor agonist | Details | |
| C00870 | BRD-K79095980 | broxuridine | antimetabolite | Details | ||
| C00871 | BRD-K23301018 | broxyquinoline | antiprotozoal agent | Details | ||
| C00872 | BRD-A36057565 | bruceantin | protein synthesis inhibitor | Details | ||
| C00873 | BRD-A41995253 | brucine | CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 | glycine receptor antagonist | Details | |
| C00874 | BRD-K47405978 | bryostatin-1 | PRKCE | protein kinase C inhibitor | Details | |
| C00875 | BRD-K31313613 | BS-181 | CDK7 | CDK inhibitor | Details | |
| C00876 | BRD-K37933329 | BTB06584 | ATP5F1 | ATPase inhibitor | Details | |
| C00877 | BRD-K89000287 | BTB1 | KIF18A | mitotic kinesin inhibitor | Details | |
| C00878 | BRD-K64178227 | BTS | Details | |||
| C00879 | BRD-A68304895 | BTS-54505 | SLC6A2|SLC6A3|SLC6A4 | dopamine reuptake inhibitor | Details | |
| C00880 | BRD-A65793993 | BTS-72664 | GABBR1 | GABA receptor antagonist | Details | |
| C00881 | BRD-K01492390 | BTT-3033 | ITGA2|ITGB1 | integrin inhibitor | Details | |
| C00882 | BRD-A53037217 | BTZ043-racemate | DPRE1 inhibitor | Details | ||
| C00883 | BRD-K55344148 | BU-224 | MAOA|MAOB | imidazoline receptor ligand | Details | |
| C00884 | BRD-K11696279 | BU-239 | imidazoline receptor ligand; imidazoline receptor agonist | Details | ||
| C00885 | BRD-A88684804 | bucetin | analgesic agent | Details | ||
| C00886 | BRD-K24697665 | bucillamine | immunosuppressant | Details | ||
| C00887 | BRD-A94624445 | bucladesine | PRKACA | adenosine receptor agonist; cAMP stimulant | Details | |
| C00888 | BRD-A91444184 | buclizine | CHRM1|HRH1 | histamine receptor antagonist | Details | |
| C00889 | BRD-A34299591 | budesonide | NR3C1 | glucocorticoid receptor agonist | Details | |
| C00890 | BRD-K18324993 | budipine | GRIN1 | glutamate receptor antagonist | Details | |
| C00891 | BRD-K36660044 | bufexamac | HDAC10|HDAC6 | cyclooxygenase inhibitor | Details | |
| C00892 | BRD-K19462402 | buflomedil | ADRA1A | adrenergic receptor antagonist; calcium channel blocker | Details | |
| C00893 | BRD-K38197229 | bumetanide | CFTR|GPR35|SLC12A1|SLC12A2|SLC12A4|SLC12A5 | solute carrier family member inhibitor | Details | |
| C00894 | BRD-K35034482 | bunazosin | ADRA1A | adrenergic receptor antagonist | Details | |
| C00895 | BRD-K42191735 | buparlisib | PIK3CA|PIK3CG | PI3K inhibitor | Details | |
| C00896 | BRD-A07947329 | buparvaquone | antiprotozoal agent | Details | ||
| C00897 | BRD-A36267905 | buphenine | ADRB2 | adrenergic receptor agonist | Details | |
| C00898 | BRD-K51700582 | bupicomide | ADRB1 | adrenergic receptor antagonist | Details | |
| C00899 | BRD-A01636364 | bupivacaine | KCNA5|PTGER1|SCN10A|SCN4A | sodium channel blocker | Details | |
| C00900 | BRD-A48420483 | bupranolol | ADRB1|ADRB2|ADRB3 | adrenergic receptor antagonist | Details |