CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C06001 | BRD-A52169337 | 2-hydroxy-4-((E)-3-(4-hydroxyphenyl)acryloyl)-2-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-6-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)cyclohexane-1,3,5-trione | Details | |||
| C06002 | BRD-K41866823 | 2-hydroxyethyl-salicylate | Details | |||
| C06003 | BRD-K82027074 | 2-hydroxyflutamide | AR | androgen receptor antagonist | Details | |
| C06004 | BRD-A27924917 | 2-hydroxysaclofen | GABBR1|GABBR2 | GABA receptor antagonist | Details | |
| C06005 | BRD-K07954936 | 2-iminobiotin | NOS1|NOS2 | nitric oxide synthase inhibitor | Details | |
| C06006 | BRD-K56634222 | 2-iodohippuric-acid | Details | |||
| C06007 | BRD-K25649279 | 2-iodomelatonin | MTNR1A|MTNR1B|NQO2 | melatonin receptor agonist | Details | |
| C06008 | BRD-K44408410 | 2-methoxyestradiol | COMT|CYP19A1|CYP1A1|CYP1B1|HIF1A|TUBB | hypoxia inducible factor inhibitor | Details | |
| C06009 | BRD-K64137799 | 2-methyl-5-hydroxytryptamine | HTR1B|HTR1D|HTR1E|HTR1F|HTR3A|HTR3B|HTR6 | serotonin receptor agonist | Details | |
| C06010 | BRD-K22327730 | 2-methyl-5-nitrophenol | Details | |||
| C06011 | BRD-K68534611 | 2-methylimidazole | cholesterol inhibitor | Details | ||
| C06012 | BRD-A51407134 | 2-octyldodecan-1-ol | Details | |||
| C06013 | BRD-K77087341 | 2-Oleoylglycerol | GPR119 | glucose dependent insulinotropic receptor ligand | Details | |
| C06014 | BRD-K89712525 | 2-oxoglutaric-acid | OXGR1 | Details | ||
| C06015 | BRD-K86587225 | 2-oxopropanoate | ABAT|AGXT2|PC|PDHB|PKLR|PKM|SLC16A1|SLC16A2|SLC16A3|SLC16A4|SLC16A5|SLC16A6|SLC16A7|SLC16A8 | pyruvate dehydrogenase kinase inhibitor | Details | |
| C06016 | BRD-K41869275 | 2-phenylmelatonin | MTNR1A|MTNR1B | melatonin receptor agonist | Details | |
| C06017 | BRD-A04661934 | 2-PMDQ | ADRA1A | adrenergic receptor antagonist | Details | |
| C06018 | BRD-K17874705 | 2-pyridylethylamine | HRH1 | histamine receptor agonist | Details | |
| C06019 | BRD-K89072800 | 2-TEDC | ALOX12 | lipoxygenase inhibitor | Details | |
| C06020 | BRD-K58819470 | 2-thiouracil | Details | |||
| C06021 | BRD-K28343777 | 20-hydroxyecdysone | ecdysone receptor modulator | Details | ||
| C06022 | BRD-K45662124 | 3'-fluorobenzylspiperone | DRD2 | dopamine receptor ligand | Details | |
| C06023 | BRD-K82903013 | 3,3'-dichlorobenzaldazine | GRM5 | glutamate receptor allosteric ligand | Details | |
| C06024 | BRD-K37846922 | 3,3'-diindolylmethane | AR|HIF1A|IFNG|PI3 | CHK inhibitor; cytochrome P450 activator; indoleamine 2,3-dioxygenase inhibitor | Details | |
| C06025 | BRD-A49947412 | 3,4-DCPG-(+/-) | GRM8 | glutamate receptor agonist | Details | |
| C06026 | BRD-K06204668 | 3,4-DCPG-(R) | glutamate receptor antagonist | Details | ||
| C06027 | BRD-K86305586 | 3,4-DCPG-(S) | GRM8 | glutamate receptor agonist | Details | |
| C06028 | BRD-K57796080 | 3,5-DHPG-(S) | GRM1 | glutamate receptor agonist | Details | |
| C06029 | BRD-A55464252 | 3-(4-methylbenzylidene)camphor | endocrine disruptor | Details | ||
| C06030 | BRD-A85216385 | 3-alpha-bis-(4-fluorophenyl)-methoxytropane | CHRM1|SLC6A2|SLC6A3|SLC6A4 | dopamine uptake inhibitor | Details | |
| C06031 | BRD-A43598550 | 3-alpha-Hydroxy-5-beta-androstan-17-one | Details | |||
| C06032 | BRD-K08703257 | 3-amino-benzamide | PARP1 | PARP inhibitor | Details | |
| C06033 | BRD-K49721826 | 3-anilinopropan-1-ol | Details | |||
| C06034 | BRD-K38370968 | 3-AQC | HTR3A | serotonin receptor agonist | Details | |
| C06035 | BRD-K24689407 | 3-bromo-7-nitroindazole | NOS1|NOS2|NOS3 | nitric oxide synthase inhibitor | Details | |
| C06036 | BRD-A62841832 | 3-bromocamphor | Details | |||
| C06037 | BRD-K92980438 | 3-bromopyruvate | HK2 | hexokinase inhibitor | Details | |
| C06038 | BRD-K76592088 | 3-carboxy-4-hydroxyphenylglycine-(R) | GRIN1|GRIN2A|GRIN2B|GRIN2C | glutamate receptor antagonist | Details | |
| C06039 | BRD-K61585876 | 3-carboxy-4-hydroxyphenylglycine-(S) | GRM1|GRM5 | glutamate receptor antagonist | Details | |
| C06040 | BRD-A51713165 | 3-CPMT | dopamine reuptake inhibitor | Details | ||
| C06041 | BRD-A79431551 | 3-deazaadenosine | AHCY | adenosylhomocysteinase inhibitor | Details | |
| C06042 | BRD-K77791657 | 3-deazaneplanocin-A | EZH2 | histone lysine methyltransferase inhibitor | Details | |
| C06043 | BRD-A26105646 | 3-deazauridine | cytidine deaminase inhibitor | Details | ||
| C06044 | BRD-A66143912 | 3-hydroxy-3-phenylpentanamide | GABA receptor modulator | Details | ||
| C06045 | BRD-K43187796 | 3-indolebutyric-acid | B2M|HLA-A|TRAC|TRBC1 | Details | ||
| C06046 | BRD-A87125127 | 3-MATIDA | GRM1 | Details | ||
| C06047 | BRD-A62890442 | 3-methyl-GABA | ABAT | GABA aminotransferase activator | Details | |
| C06048 | BRD-K81647657 | 3-methyladenine | PI3 | PI3K inhibitor | Details | |
| C06049 | BRD-K62581435 | 3-MPPI | ADRA1A | adrenergic receptor ligand | Details | |
| C06050 | BRD-K58413118 | 3PO | PFKFB3 | phosphofructokinase inhibitor | Details | |
| C06051 | BRD-K51799616 | 4,4'-DDT | Details | |||
| C06052 | BRD-K49545903 | 4,4-pentamethylenepiperidine | M2 channel blocker | Details | ||
| C06053 | BRD-K97118047 | 4,5,6,7-tetrabromobenzotriazole | AKT1|CHEK1|CSNK2A1|GSK3B|LCK|MAP2K1|MAPK1|MAPK11|MAPK12|MAPK14|MAPK8|PRKCA|ROCK1|RPS6KB1|SGK1 | casein kinase inhibitor | Details | |
| C06054 | BRD-K47337578 | 4-(4-fluorobenzoyl)-1-(4-phenylbutyl)-piperidine | HTR2A | serotonin receptor antagonist | Details | |
| C06055 | BRD-K97019106 | 4-acetyl-1,1-dimethylpiperazinium | acetylcholine receptor agonist | Details | ||
| C06056 | BRD-K65544384 | 4-aminohippuric-acid | SLC22A6 | Details | ||
| C06057 | BRD-A80383043 | 4-carboxy-3-hydroxyphenylglycine-(RS) | GRM1 | glutamate receptor agonist; glutamate receptor antagonist | Details | |
| C06058 | BRD-K74133873 | 4-carboxy-3-hydroxyphenylglycine-(S) | GRM1|GRM2 | glutamate receptor agonist; glutamate receptor antagonist | Details | |
| C06059 | BRD-K39160765 | 4-chlorophenylguanidine | PLAUR | urokinase inhibitor | Details | |
| C06060 | BRD-A54139254 | 4-CMTB | FFAR2 | free fatty acid receptor agonist | Details | |
| C06061 | BRD-K29313239 | 4-DAMP | CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 | cholinergic receptor antagonist | Details | |
| C06062 | BRD-A32796301 | 4-galactosyllactose | AMY2B | Details | ||
| C06063 | BRD-K91758890 | 4-HQN | PARP1 | PARP inhibitor | Details | |
| C06064 | BRD-K49759007 | 4-hydroxy-phenazone | Details | |||
| C06065 | BRD-K62537556 | 4-IBP | SIGMAR1 | sigma receptor agonist | Details | |
| C06066 | BRD-K66664625 | 4-iodo-L-phenylalanine | DPP4 | Details | ||
| C06067 | BRD-K25690923 | 4-iodo-6-phenylpyrimidine | MIF | macrophage migration inhibiting factor inhibitor | Details | |
| C06068 | BRD-K73303757 | 4-methylgenistein | CYP19A1|ESRRA|ESRRB|ESRRG|FASN | protein tyrosine kinase inhibitor | Details | |
| C06069 | BRD-K70821460 | 4-methylhistamine | HRH4 | histamine receptor agonist | Details | |
| C06070 | BRD-K81316007 | 4-mu-8C | ERN1 | IRE1 inhibitor | Details | |
| C06071 | BRD-A67482312 | 4-P-PDOT | MTNR1A|MTNR1B | melatonin receptor antagonist | Details | |
| C06072 | BRD-K41024817 | 4-phenolsulfonic-acid | Details | |||
| C06073 | BRD-M10474530 | 4-phenyl-1,2,3,4-tetrahydroisoquinoline | dopamine release inhibitor | Details | ||
| C06074 | BRD-K78061844 | 4-PPBP | SIGMAR1 | sigma receptor ligand | Details | |
| C06075 | BRD-K42108215 | 4-propylbenzoic-acid | Details | |||
| C06076 | BRD-K04552268 | 4-pyrimidinecarbonitrile | Details | |||
| C06077 | BRD-K06338106 | 4-tert-butylphenol | Details | |||
| C06078 | BRD-A18598741 | 4BP-TQS | CHRNA7 | nicotinic receptor agonist | Details | |
| C06079 | BRD-K52366702 | 4EGI-1 | EIF4E | protein synthesis inhibitor | Details | |
| C06080 | BRD-K67173685 | 4E1RCat | EIF4E|EIF4G1 | protein synthesis inhibitor | Details | |
| C06081 | BRD-K11773281 | 4SC-202 | HDAC1 | HDAC inhibitor | Details | |
| C06082 | BRD-A13598753 | 5'-Chloro-5'-deoxy-ENBA-(+/-) | ADORA1 | adenosine receptor agonist | Details | |
| C06083 | BRD-K60287130 | 5,7-dichlorokynurenic-acid | GLRA2|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D | glutamate receptor antagonist | Details | |
| C06084 | BRD-A61299447 | 5,7-Dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-2H-chromene-3,4-dione | Details | |||
| C06085 | BRD-K58146797 | 5-(4chlorophenyl)-4-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one | Details | |||
| C06086 | BRD-K87535339 | 5-Amino-3-D-ribofuranosylthiazolo[4,5-d]pyrimidin-2,7(3H,6H)-dione | Details | |||
| C06087 | BRD-K57631554 | 5-aminolevulinic-acid | ALAD | oxidizing agent | Details | |
| C06088 | BRD-K33690734 | 5-BDBD | P2RX4 | purinergic receptor antagonist | Details | |
| C06089 | BRD-K92382976 | 5-carboxamidotryptamine | HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR5A|HTR6|HTR7 | serotonin receptor agonist | Details | |
| C06090 | BRD-K73381198 | 5-fluoro-3-pyridyl-methanol | Details | |||
| C06091 | BRD-K24844714 | 5-fluorouracil | DPYD|TYMS | thymidylate synthase inhibitor | Details | |
| C06092 | BRD-K34437622 | 5-FP | TYMS | thymidylate synthase inhibitor | Details | |
| C06093 | BRD-K86799112 | 5-HMF | Details | |||
| C06094 | BRD-K03871161 | 5-hydroxyectoine | Details | |||
| C06095 | BRD-K24603946 | 5-hydroxymethyl-tolterodine | CHRM3 | acetylcholine receptor antagonist | Details | |
| C06096 | BRD-A73930134 | 5-hydroxytryptophan | SLC36A1|SLC36A2 | neurotransmitter | Details | |
| C06097 | BRD-K90065682 | 5-iodo-A-85380 | acetylcholine receptor agonist | Details | ||
| C06098 | BRD-K45437867 | 5-methylfurmethiodide | CHRM1|CHRM2|CHRM3|CHRM4 | acetylcholine receptor agonist | Details | |
| C06099 | BRD-K06050544 | 5-methylhydantoin-(D) | Details | |||
| C06100 | BRD-K56033645 | 5-methylhydantoin-(L) | Details |