CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

CMap Candidates

CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.

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Associated NAFLD Targets:

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6125 records.

CMap ID	Pert ID	Compound Name	Targets	MoA
C01301	BRD-K34303607	CKI-7	CSNK1G2	casein kinase inhibitor	Details
C01302	BRD-K00662280	CL-218872	GABRA1\|GABRA2\|GABRA3\|GABRA5\|GABRB2\|GABRG2	benzodiazepine receptor agonist	Details
C01303	BRD-K87573013	CL-225385			Details
C01304	BRD-K93034159	cladribine	ADA\|PNP\|POLA1\|POLE\|POLE2\|POLE3\|POLE4\|RRM1\|RRM2\|RRM2B	adenosine deaminase inhibitor; ribonucleotide reductase inhibitor	Details
C01305	BRD-K49668410	clarithromycin	CYP3A4	bacterial 50S ribosomal subunit inhibitor	Details
C01306	BRD-K94250879	clavulanate		beta lactamase inhibitor	Details
C01307	BRD-K17294426	clebopride	ACHE\|DRD2	dopamine receptor antagonist	Details
C01308	BRD-K30240666	clemastine	HRH1	histamine receptor antagonist	Details
C01309	BRD-K04704168	clemizole		HCV inhibitor	Details
C01310	BRD-A75726477	clenbuterol	ADRB1\|ADRB2\|ADRB3\|NGF\|TNF	adrenergic receptor agonist	Details
C01311	BRD-A01563671	cleviprex	CACNA1C\|CACNA1D\|CACNA1F\|CACNA1S	calcium channel blocker	Details
C01312	BRD-K18948558	clevudine		DNA polymerase inhibitor	Details
C01313	BRD-A46066006	clidinium	CHRM1\|CHRM3	acetylcholine receptor antagonist	Details
C01314	BRD-A61676498	climbazole		enzyme inducer	Details
C01315	BRD-A93964801	clinafloxacin		bacterial DNA gyrase inhibitor	Details
C01316	BRD-K23586533	clindamycin		protein synthesis inhibitor	Details
C01317	BRD-A76672327	clindamycin-palmitate		bacterial 50S ribosomal subunit inhibitor	Details
C01318	BRD-K27771035	clindamycin-phosphate		protein synthesis inhibitor	Details
C01319	BRD-A90625545	clinofibrate	LPL	lipase clearing factor inhibitor	Details
C01320	BRD-K09255212	clioquinol	OPRK1	chelating agent	Details
C01321	BRD-K52408781	clobazam	GABRA1\|GABRA2\|GABRA3\|GABRA4\|GABRA5\|GABRA6\|GABRB1\|GABRB2\|GABRB3\|GABRD\|GABRE\|GABRG1\|GABRG2\|GABRG3\|GABRP\|GABRQ	GABA benzodiazepine site receptor agonist	Details
C01322	BRD-K71430621	clobenpropit	HRH1\|HRH2\|HRH3\|HRH4	histamine receptor antagonist	Details
C01323	BRD-K10799896	clobetasol-propionate	NR3C1\|PLA2G1B	glucocorticoid receptor agonist	Details
C01324	BRD-K58810291	clobetasone-butyrate	NR3C1	corticosteroid agonist	Details
C01325	BRD-A43809092	clobutinol		antitussive	Details
C01326	BRD-K38003476	clocortolone-pivalate	NR3C1\|PLA2G1B	steroid	Details
C01327	BRD-K72542090	clodronic-acid	SLC25A4\|SLC25A5\|SLC25A6	bone resorption inhibitor	Details
C01328	BRD-K34022604	clofarabine	POLA1\|POLD1\|POLE\|RRM1\|RRM2\|RRM2B	ribonucleotide reductase inhibitor	Details
C01329	BRD-K56614220	clofazimine		GK0582 inhibitor	Details
C01330	BRD-A15687940	clofedanol	HRH1	histamine receptor antagonist	Details
C01331	BRD-K45252063	clofibrate	LPL\|PPARA	PPAR receptor agonist	Details
C01332	BRD-K19111024	clofibric-acid	PPARA	PPAR receptor agonist	Details
C01333	BRD-K02680176	clofilium	KCNA5\|KCNH1	potassium channel blocker	Details
C01334	BRD-K02900412	clofoctol		protein synthesis inhibitor	Details
C01335	BRD-K39230570	clomesone		DNA inhibitor	Details
C01336	BRD-K50422030	clomethiazole	GABRA1	GABA receptor antagonist; GABA receptor modulator	Details
C01337	BRD-K29950728	clomifene	ESR1	estrogen receptor antagonist	Details
C01338	BRD-K52989797	clomipramine	GSTP1\|HTR2A\|HTR2B\|HTR2C\|SLC6A2\|SLC6A3\|SLC6A4	serotonin transporter (SERT) inhibitor	Details
C01339	BRD-K38183498	clonazepam	GABRA1\|GABRA2\|GABRA3\|GABRA4\|GABRA5\|GABRA6\|GABRB1\|GABRB2\|GABRB3\|GABRD\|GABRE\|GABRG1\|GABRG2\|GABRG3\|GABRP\|GABRQ\|TSPO	GABA benzodiazepine site receptor agonist	Details
C01340	BRD-K98530306	clonidine	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C	adrenergic receptor agonist	Details
C01341	BRD-M63173034	clonixin-lysinate		cyclooxygenase inhibitor	Details
C01342	BRD-A85651701	clopamide		sodium/chloride cotransporter inhibitor	Details
C01343	BRD-A80908310	cloperastine		antitussive	Details
C01344	BRD-K27721098	clopidogrel	P2RY12	purinergic receptor antagonist	Details
C01345	BRD-K80036624	clopidol			Details
C01346	BRD-K17850764	cloprostenol-(+/-)	PTGDR\|PTGER1\|PTGER3\|PTGFR\|TBXA2R	prostaglandin receptor agonist	Details
C01347	BRD-A04971881	cloranolol	ADRB1\|ADRB2\|ADRB3	adrenergic receptor antagonist	Details
C01348	BRD-K73251053	clorgiline	MAOA	monoamine oxidase inhibitor	Details
C01349	BRD-A19053834	clorotepine	ADRA1A\|ADRA1B\|ADRA1D\|DRD2\|HRH1\|HTR2C\|HTR6	dopamine receptor antagonist; adrenergic receptor antagonist	Details
C01350	BRD-A29281099	clorprenaline	ADRB1\|ADRB2	adrenergic receptor agonist	Details
C01351	BRD-K97521363	clorsulon		glycolysis inhibitor	Details
C01352	BRD-A19952358	closantel		chitinase inhibitor; NFkB pathway inhibitor	Details
C01353	BRD-K10990317	clotiapine			Details
C01354	BRD-K15916496	clotrimazole	CYP3A4\|KCNN4\|NR1I2\|NR1I3\|TRPM2\|TRPM4\|TRPM8	cytochrome P450 inhibitor; imidazoline receptor ligand	Details
C01355	BRD-K01244426	cloxacillin		bacterial cell wall synthesis inhibitor	Details
C01356	BRD-K46982791	cloxyquin	KCNK18	potassium channel activator	Details
C01357	BRD-K37289225	clozapine	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C\|CALY\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD1\|DRD2\|DRD3\|DRD4\|DRD5\|HRH1\|HRH4\|HTR1A\|HTR1B\|HTR1D\|HTR1E\|HTR1F\|HTR2A\|HTR2B\|HTR2C\|HTR3A\|HTR5A\|HTR6\|HTR7	dopamine receptor antagonist; serotonin receptor antagonist	Details
C01358	BRD-K06467130	CL316243	ADRB3\|UCP1\|UCP2\|UCP3	adrenergic receptor agonist	Details
C01359	BRD-K54095730	CMPD-1	GNRHR\|MAPK14	p38 MAPK inhibitor	Details
C01360	BRD-K19438463	CNQX	GRIA1\|GRIA2\|GRIA3\|GRIA4	glutamate receptor antagonist	Details
C01361	BRD-K24869513	CNX-2006	EGFR	EGFR inhibitor	Details
C01362	BRD-K48443249	CNX-774	BTK	Bruton's tyrosine kinase (BTK) inhibitor	Details
C01363	BRD-K55677650	CO-101244	GRIN2B	glutamate receptor antagonist	Details
C01364	BRD-K70912147	co-102862	SCN4A\|SCN9A		Details
C01365	BRD-K51040301	cobicistat	CYP3A4\|CYP3A43\|CYP3A5\|CYP3A7	cytochrome P450 inhibitor	Details
C01366	BRD-K03390685	cobimetinib		MEK inhibitor	Details
C01367	BRD-A67956599	coenzyme-a	ACAT2\|CRAT\|CS\|DBI\|HMGCR\|KAT2A\|KAT2B\|KAT5		Details
C01368	BRD-A84188517	coenzyme-i	AASS\|ACADS\|ADH1A\|ADH1B\|ADH1C\|ADH4\|ADH5\|ADH7\|AKR1B1\|AKR1C1\|AKR1C2\|AKR1C3\|AKR1C4\|ALDH1A1\|ALDH1A2\|ALDH1A3\|ALDH1B1\|ALDH2\|ALDH3A1\|ALDH3A2\|ALDH3B1\|ALDH3B2\|ALDH4A1\|ALDH5A1\|ALDH6A1\|ALDH7A1\|ALDH9A1\|AMT\|BDH1\|BLVRA\|BLVRB\|CDO1\|CYB5R3\|CYP17A1\|CYP4A11\|DHCR7\|DHFR\|DLAT\|DLD\|EHHADH\|GAPDH\|GAPDHS\|GLUD1\|GLUD2\|GPD1\|GSR\|H6PD\|HADH\|HADHA\|HIBADH\|HMGCR\|HMOX1\|HMOX2\|HPGD\|HSD11B1\|HSD11B2\|HSD17B1\|HSD17B10\|HSD17B2\|HSD17B3\|HSD17B4\|HSD17B7\|HSD17B8\|HSD3B1\|HSD3B2\|IDH3A\|IDH3B\|IDH3G\|IMPDH1\|IMPDH2\|LDHA\|LDHAL6A\|LDHAL6B\|LDHB\|LDHC\|MDH1\|MDH2\|ME1\|ME2\|ME3\|MSMO1\|MT-ND1\|MT-ND2\|MT-ND3\|MT-ND4\|MT-ND4L\|MT-ND5\|MT-ND6\|MTHFD1\|MTHFD2\|NDUFA1\|NDUFA10\|NDUFA11\|NDUFA12\|NDUFA13\|NDUFA2\|NDUFA3\|NDUFA4\|NDUFA4L2\|NDUFA5\|NDUFA6\|NDUFA7\|NDUFA8\|NDUFA9\|NDUFAB1\|NDUFB1\|NDUFB10\|NDUFB2\|NDUFB3\|NDUFB4\|NDUFB5\|NDUFB6\|NDUFB7\|NDUFB8\|NDUFB9\|NDUFC1\|NDUFC2\|NDUFS1\|NDUFS2\|NDUFS3\|NDUFS4\|NDUFS5\|NDUFS6\|NDUFS7\|NDUFS8\|NDUFV1\|NDUFV2\|NDUFV3\|NNT\|NQO2\|NSDHL\|OGDH\|PDHA1\|PDHA2\|PDHB\|PHGDH\|PYCR1\|PYCR2\|QDPR\|RDH5\|SORD\|TSTA3\|TYR\|UGDH		Details
C01369	BRD-K75043328	coenzyme-q10			Details
C01370	BRD-K00259736	colchicine	GLRA1\|GLRA2\|TUBA1A\|TUBA1B\|TUBA1C\|TUBA3C\|TUBA3D\|TUBA3E\|TUBA4A\|TUBB\|TUBB1\|TUBB2A\|TUBB2B\|TUBB3\|TUBB4A\|TUBB4B\|TUBB6\|TUBB8	microtubule inhibitor	Details
C01371	BRD-U08520523	colesevalam			Details
C01372	BRD-A55416093	colforsin	ADCY2\|ADCY5	adenylyl cyclase activator	Details
C01373	BRD-K19388745	colforsin-daproate		adenylyl cyclase activator	Details
C01374	BRD-A95886749	colfosceril-palmitate		pulmonary surfactant	Details
C01375	BRD-A13668387	colistimethate		bacterial permeability inducer	Details
C01376	BRD-A18924964	colistin		bacterial permeability inducer	Details
C01377	BRD-A36456202	colistin-b-sulfate		bacterial permeability inducer	Details
C01378	BRD-A45201156	colistin-sulfate		bacterial permeability inducer	Details
C01379	BRD-K61195623	combretastatin-A-4		tubulin polymerization inhibitor	Details
C01380	BRD-K98143539	compound-w	BACE1	beta-secretase inhibitor	Details
C01381	BRD-K19655798	compound-401	MTOR\|PRKDC	DNA dependent protein kinase inhibitor	Details
C01382	BRD-K76139886	compound-58112			Details
C01383	BRD-K37385792	conivaptan	AVPR1A\|AVPR2	vasopressin receptor antagonist	Details
C01384	BRD-K24666289	copanlisib	PIK3CA\|PIK3CB\|PIK3CD\|PIK3CG	PI3K inhibitor	Details
C01385	BRD-K36449075	copper-histidine	HAL\|HARS\|HDC\|SLC15A3\|SLC15A4\|SLC38A3\|SLC38A5		Details
C01386	BRD-K74965187	COR-170	CNR2	cannabinoid receptor inverse agonist	Details
C01387	BRD-K65428967	cordycepin		DNA inhibitor	Details
C01388	BRD-K27885593	corosolic-acid	HSD11B1\|PTPN1	PKC inhibitor; protein tyrosine kinase inhibitor	Details
C01389	BRD-K73589401	corticosterone	HSD11B1\|NCOA1\|NR3C2	mineralocorticoid receptor agonist	Details
C01390	BRD-A62731508	cortisone	NR3C1	glucocorticoid receptor agonist	Details
C01391	BRD-K86161929	cortisone-acetate	NR3C1	glucocorticoid receptor agonist	Details
C01392	BRD-K43736954	cortodoxone	AR	androgen receptor antagonist	Details
C01393	BRD-K26833429	costunolide		telomerase inhibitor	Details
C01394	BRD-K98710228	cot-inhibitor-1	MAP3K8	MAPK-interacting kinase inhibitor	Details
C01395	BRD-K49468759	cot-inhibitor-2	MAP3K8	MAPK-interacting kinase inhibitor	Details
C01396	BRD-K94144010	cotinine		nicotine metabolite	Details
C01397	BRD-K23913458	coumarin	CA1\|CA12\|CA14\|CA2\|CA4\|CA6\|CA9\|CYP2A6	vitamin K antagonist	Details
C01398	BRD-K41567533	coumophos		cholinesterase inhibitor	Details
C01399	BRD-K53913008	CP-316819	PYGL	glycogen phosphorylase inhibitor	Details
C01400	BRD-K52113681	CP-339818	KCNA3	potassium channel blocker	Details