CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C01801 | BRD-A64553394 | DPI-201106 | ADRB2 | sodium channel activator | Details | |
| C01802 | BRD-K99922388 | DPO-1 | KCNA5 | potassium channel blocker | Details | |
| C01803 | BRD-K80315159 | DPPE | ABCB1|HRH1 | histamine receptor antagonist | Details | |
| C01804 | BRD-A67976398 | DQP-1105 | GRIN2C|GRIN2D | glutamate receptor antagonist | Details | |
| C01805 | BRD-K94920105 | DR-2313 | PARP1|PARP3 | PARP inhibitor | Details | |
| C01806 | BRD-A39794701 | DR-4485 | HTR7 | serotonin receptor antagonist | Details | |
| C01807 | BRD-K25486274 | DRF053-(R) | CSNK1A1 | CDK inhibitor | Details | |
| C01808 | BRD-A22267103 | drofenine | Details | |||
| C01809 | BRD-K38477637 | droloxifene | ESR1 | selective estrogen receptor modulator (SERM) | Details | |
| C01810 | BRD-A38706605 | dromostanolone-propionate | AR | androgen receptor modulator | Details | |
| C01811 | BRD-K05524748 | dronedarone | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|CACNA1C|CACNA1D|CACNA1F|CACNA1S|CACNB1|CACNB2|CACNB3|CACNB4|KCNA5|KCNH2|KCNK2|SCN1A | adrenergic receptor antagonist | Details | |
| C01812 | BRD-K97158071 | droperidol | ADRA1A|DRD2|DRD3|DRD4|HTR2A | dopamine receptor antagonist | Details | |
| C01813 | BRD-A29349577 | dropropizine | antitussive | Details | ||
| C01814 | BRD-K04394237 | drospirenone | AR|NR3C2|PGR | mineralocorticoid receptor antagonist | Details | |
| C01815 | BRD-K14658796 | drotaverine | CACNA1C|PDE4A | phosphodiesterase inhibitor | Details | |
| C01816 | BRD-K17219082 | droxicam | PTGS1 | cyclooxygenase inhibitor | Details | |
| C01817 | BRD-K20372197 | droxidopa | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|ADRB3|PAH | norepinephrine precursor | Details | |
| C01818 | BRD-K11558771 | droxinostat | HDAC6|HDAC8 | HDAC inhibitor | Details | |
| C01819 | BRD-K46384285 | DSR-6434 | TLR7 | toll-like receptor agonist | Details | |
| C01820 | BRD-K09619578 | DS2-(806622) | Details | |||
| C01821 | BRD-K08859203 | DU-728 | ITGA2B|ITGB3 | structural glycoprotein antagonist | Details | |
| C01822 | BRD-K71103788 | duloxetine | HTR2A|HTR2C|HTR6|SLC6A2|SLC6A3|SLC6A4 | norepinephrine reuptake inhibitor; serotonin norepinephrine reuptake inhibitor (SNRI) | Details | |
| C01823 | BRD-K06221026 | DUP-697 | PTGS2 | cyclooxygenase inhibitor | Details | |
| C01824 | BRD-K30373883 | dutasteride | SRD5A1|SRD5A2 | 5 alpha reductase inhibitor | Details | |
| C01825 | BRD-K22520627 | DVD-111 | Details | |||
| C01826 | BRD-K72259270 | dyclonine | SCN10A|SCN5A | sodium channel blocker | Details | |
| C01827 | BRD-K68620903 | dydrogesterone | PGR | progesterone receptor agonist | Details | |
| C01828 | BRD-K87718015 | dynasore | DNM1|DNM1L|DNM2 | dynamin inhibitor | Details | |
| C01829 | BRD-K23479488 | dynole-34-2 | DNM1 | dynamin inhibitor | Details | |
| C01830 | BRD-A00827783 | dyphylline | ADORA1|ADORA2A|PDE3A|PDE4A|PDE4B|PDE4C|PDE4D|PDE7A|PDE7B | adenosine receptor antagonist; phosphodiesterase inhibitor | Details | |
| C01831 | BRD-K58343622 | DY131 | ESRRB|ESRRG | estrogen-related receptor agonist | Details | |
| C01832 | BRD-A77118605 | D609 | phospholipase inhibitor | Details | ||
| C01833 | BRD-K50564936 | E-2012 | APH1A|APH1B|PSENEN | gamma secretase modulator | Details | |
| C01834 | BRD-K41713976 | E-4031 | KCNH1|KCNH2 | potassium channel blocker | Details | |
| C01835 | BRD-K06273313 | E-64 | CTSS | cysteine protease inhibitor; calpain inhibitor | Details | |
| C01836 | BRD-K53030960 | eact | ANO1 | calcium-activated chloride channel inhibitor | Details | |
| C01837 | BRD-K66998413 | EB-47 | PARP1 | PARP inhibitor | Details | |
| C01838 | BRD-K13314656 | ebastine | CYP3A4|HRH1 | histamine receptor antagonist | Details | |
| C01839 | BRD-A96485169 | EBPC | AKR1B1 | aldose reductase inhibitor | Details | |
| C01840 | BRD-K22421059 | ebrotidine | HRH2 | histamine receptor antagonist | Details | |
| C01841 | BRD-K29359156 | ebselen | ALB | cyclooxygenase inhibitor; glutathione peroxidase agonist; H+/K+-ATPase inhibitor; nitric oxide synthase inhibitor | Details | |
| C01842 | BRD-K41705163 | EC-144 | HSP90AA1|HSP90AB1 | HSP inhibitor | Details | |
| C01843 | BRD-K81004638 | EC-23 | RARA|RARB|RARG | retinoid receptor agonist | Details | |
| C01844 | BRD-K47371940 | ecabapide | Details | |||
| C01845 | BRD-K03353589 | ecabet | NOXO1 | gastrin inhibitor; urease inhibitor | Details | |
| C01846 | BRD-A47953250 | ecamsule-triethanolamine | Details | |||
| C01847 | BRD-A68969091 | echinomycin | DNA intercalating agent | Details | ||
| C01848 | BRD-A51820102 | econazole | CYP51A1|NPY1R|NPY2R|TRPM2|TRPV5 | lanosterol demethylase inhibitor; sterol demethylase inhibitor | Details | |
| C01849 | BRD-K60902958 | ectoine-zwitterion | Details | |||
| C01850 | BRD-A25182582 | edaglitazone | PPARG | PPAR receptor agonist | Details | |
| C01851 | BRD-K35458079 | edaravone | BCL2 | nootropic agent | Details | |
| C01852 | BRD-A30403214 | edelfosine | phospholipase inhibitor | Details | ||
| C01853 | BRD-A78588743 | editol | Details | |||
| C01854 | BRD-K29322660 | edoxaban | F10 | coagulation factor inhibitor | Details | |
| C01855 | BRD-K86892782 | edoxudine | DNA directed DNA polymerase inhibitor | Details | ||
| C01856 | BRD-K81128206 | edrophonium | ACHE|BCHE | acetylcholinesterase inhibitor | Details | |
| C01857 | BRD-K54542929 | EDTMP | chelating agent | Details | ||
| C01858 | BRD-K19002914 | EED226 | EED | polycomb protein inhibitor | Details | |
| C01859 | BRD-K37355418 | efaproxiral | HBA1|HBB | haemoglobin oxygen release stimulant | Details | |
| C01860 | BRD-A10739734 | efaroxan | ADORA2A | adrenergic receptor antagonist | Details | |
| C01861 | BRD-A24560335 | efatutazone | PPARG | PPAR receptor agonist | Details | |
| C01862 | BRD-K40758068 | efavirenz | CYP1A2|CYP2B6|CYP2C19|CYP2C9|CYP2D6|CYP3A4 | HIV protease inhibitor | Details | |
| C01863 | BRD-A30774155 | efinaconazole | CYP51A1 | lanosterol demethylase inhibitor | Details | |
| C01864 | BRD-A96292436 | eflornithine | ARG2|ODC1 | ornithine decarboxylase inhibitor | Details | |
| C01865 | BRD-K55166090 | efloxate | vasodilator | Details | ||
| C01866 | BRD-M92675308 | efonidipine-monoethanolate | CACNA1C|CACNA1G | L-type calcium channel blocker; T-type calcium channel blocker | Details | |
| C01867 | BRD-K22514639 | EGF816 | EGFR | EGFR inhibitor | Details | |
| C01868 | BRD-K65359424 | eglumetad | GRM2|GRM3|GRM6|GRM8 | glutamate receptor agonist | Details | |
| C01869 | BRD-K50653584 | EG00229 | NRP1 | neuropilin receptor antagonist | Details | |
| C01870 | BRD-K32289541 | EHop-016 | RAC1|RAC3 | Ras GTPase inhibitor | Details | |
| C01871 | BRD-K88120876 | EIPA | ADRA2A|ASIC1|PKD2L1 | transient receptor potential polycystic inhibitor; sodium/hydrogen exchanger inhibitor | Details | |
| C01872 | BRD-K81623406 | EIT-hydrobromide | NOS2|NOS3 | nitric oxide synthase inhibitor | Details | |
| C01873 | BRD-K91535048 | EI1 | EZH2 | histone lysine methyltransferase inhibitor | Details | |
| C01874 | BRD-K88807631 | elacridar | ABCB1 | P glycoprotein inhibitor | Details | |
| C01875 | BRD-K63876426 | elactocin | XPO1 | exportin antagonist | Details | |
| C01876 | BRD-K03165895 | elafibranor | PPARA|PPARD | PPAR receptor agonist | Details | |
| C01877 | BRD-K55808645 | elagolix | GNRHR | gonadotropin releasing factor hormone receptor antagonist | Details | |
| C01878 | BRD-K09735259 | elbasvir | HCV inhibitor | Details | ||
| C01879 | BRD-K79565391 | elemene | VEGFR inhibitor | Details | ||
| C01880 | BRD-K82135108 | elesclomol | HSPA1A | oxidative stress inducer | Details | |
| C01881 | BRD-K30652337 | eletriptan | HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2B|HTR7 | serotonin receptor agonist | Details | |
| C01882 | BRD-K86410485 | eliglustat | UGCG | Glycosyl transferase inhibitor | Details | |
| C01883 | BRD-K59271229 | elinogrel | P2RY12 | purinergic receptor antagonist | Details | |
| C01884 | BRD-A61392169 | eliprodil | GRIN1|GRIN2B | glutamate receptor antagonist | Details | |
| C01885 | BRD-K30466858 | ellagic-acid | CA1|CA12|CA14|CA2|CA3|CA4|CA5A|CA5B|CA6|CA7|CA9|CSNK2A1|GSK3B|PRKACA|PRKCA|PRKCB|SQLE|SYK | glutathione transferase inhibitor; non-nucleoside reverse transcriptase inhibitor | Details | |
| C01886 | BRD-K50699835 | ELN-441958 | BDKRB1 | bradykinin receptor antagonist | Details | |
| C01887 | BRD-K18172896 | eltanolone | GABRA1|GABRB2|GABRG2 | membrane integrity inhibitor | Details | |
| C01888 | BRD-K86171477 | eltoprazine | HTR1A|HTR1B | serotonin receptor agonist | Details | |
| C01889 | BRD-K40496271 | eltrombopag | MPL | thrombopoietin receptor agonist | Details | |
| C01890 | BRD-K39560679 | eluxadoline | OPRD1|OPRK1|OPRM1 | opioid receptor modulator | Details | |
| C01891 | BRD-K54472332 | elvitegravir | HIV integrase inhibitor | Details | ||
| C01892 | BRD-K86727142 | embelin | XIAP | HCV inhibitor; XIAP inhibitor | Details | |
| C01893 | BRD-K97963946 | EMD-1214063 | MET | hepatocyte growth factor receptor inhibitor | Details | |
| C01894 | BRD-K47659338 | EMD-386088 | HTR6 | serotonin receptor agonist | Details | |
| C01895 | BRD-A65248799 | EMD-53998 | TNNC1 | phosphodiesterase inhibitor | Details | |
| C01896 | BRD-K88759641 | EMD-66684 | AGTR1 | angiotensin receptor antagonist | Details | |
| C01897 | BRD-K15010214 | emedastine | HRH1 | histamine receptor antagonist | Details | |
| C01898 | BRD-A25687296 | emetine | RPS2 | protein synthesis inhibitor | Details | |
| C01899 | BRD-K58685305 | emodin | CSNK2A1 | 11-beta hydroxysteroid dehydrogenase inhibitor | Details | |
| C01900 | BRD-K90629600 | emorfazone | antiinflammatory agent; cyclooxygenase inhibitor | Details |