CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C02801 | BRD-K87774949 | istradefylline | ADORA1|ADORA2A|ADORA2B|ADORA3 | adenosine receptor antagonist | Details | |
| C02802 | BRD-K53903639 | ISX-9 | NEUROD1 | neural stem cell inducer | Details | |
| C02803 | BRD-K67482377 | itacitinib | JAK1 | JAK inhibitor | Details | |
| C02804 | BRD-A56690687 | ITD-1 | TGFBR2 | TGF beta receptor inhibitor | Details | |
| C02805 | BRD-K60298136 | ITE | AHR | aryl hydrocarbon receptor agonist | Details | |
| C02806 | BRD-K77987496 | ITI214 | PDE1A | phosphodiesterase inhibitor | Details | |
| C02807 | BRD-K96740444 | itopride | CHRM3|DRD2 | dopamine receptor antagonist | Details | |
| C02808 | BRD-A23067620 | itraconazole | CYP51A1 | cytochrome P450 inhibitor | Details | |
| C02809 | BRD-K36515744 | ITX3 | TRIO | GEF inhibitor | Details | |
| C02810 | BRD-K73499906 | IT1t | CXCR4 | CC chemokine receptor antagonist | Details | |
| C02811 | BRD-K45841694 | IU1 | USP14 | ubiquitin C-terminal hydrolase inhibitor | Details | |
| C02812 | BRD-K31385749 | ivabradine | HCN1|HCN3|HCN4 | HCN channel antagonist; potassium channel blocker; sodium channel blocker | Details | |
| C02813 | BRD-K52818472 | ivacaftor | CFTR | CFTR channel potentiator | Details | |
| C02814 | BRD-K85554912 | ivermectin | CHRNA7|GABRB3|GLRA3|P2RX7 | benzodiazepine receptor agonist | Details | |
| C02815 | BRD-K93073858 | ivosidenib | IDH1 | isocitrate dehydrogenase inhibitor | Details | |
| C02816 | BRD-K53234107 | IWP-L6 | PORCN | porcupine inhibitor | Details | |
| C02817 | BRD-K03601870 | ixabepilone | TUBA1A|TUBA1B|TUBA1C|TUBA3C|TUBA3D|TUBA3E|TUBA4A|TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8 | microtubule stabilizing agent | Details | |
| C02818 | BRD-K78659596 | ixazomib | proteasome inhibitor | Details | ||
| C02819 | BRD-A66419424 | ixazomib-citrate | proteasome inhibitor | Details | ||
| C02820 | BRD-K95676198 | JAK3-inhibitor-V | JAK3 | JAK inhibitor | Details | |
| C02821 | BRD-K95837862 | JDTic | OPRK1 | opioid receptor antagonist | Details | |
| C02822 | BRD-K32892871 | JHW-007 | SLC6A3 | dopamine uptake inhibitor | Details | |
| C02823 | BRD-K76180386 | JIB04 | KDM4E | histone lysine demethylase inhibitor | Details | |
| C02824 | BRD-K38860038 | JK-184 | hedgehog pathway inhibitor | Details | ||
| C02825 | BRD-K22010301 | JLK-6 | PSEN1 | gamma secretase inhibitor | Details | |
| C02826 | BRD-K15086322 | JNJ-10191584 | HRH4 | histamine receptor antagonist | Details | |
| C02827 | BRD-K61721596 | JNJ-10397049 | HCRTR1|HCRTR2 | orexin receptor antagonist | Details | |
| C02828 | BRD-K25596805 | JNJ-16259685 | GRM1 | glutamate receptor antagonist | Details | |
| C02829 | BRD-K47376733 | JNJ-1661010 | FAAH | FAAH inhibitor | Details | |
| C02830 | BRD-K51770398 | JNJ-17203212 | TRPV1 | TRPV antagonist | Details | |
| C02831 | BRD-K83837640 | JNJ-26481585 | HDAC1|HDAC10|HDAC11|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9|MDM2 | HDAC inhibitor | Details | |
| C02832 | BRD-K24864897 | JNJ-26990990 | anticonvulsant | Details | ||
| C02833 | BRD-K41895652 | JNJ-27141491 | CCR2 | CC chemokine receptor antagonist | Details | |
| C02834 | BRD-K31802667 | JNJ-37822681 | DRD2 | dopamine receptor antagonist | Details | |
| C02835 | BRD-K02123250 | JNJ-38877605 | MET | tyrosine kinase inhibitor | Details | |
| C02836 | BRD-K55029398 | JNJ-40411813 | GRM2 | glutamate receptor positive allosteric modulator | Details | |
| C02837 | BRD-K01036220 | JNJ-42041935 | PDK2 | hypoxia inducible factor prolyl hydroxylase inhibitor | Details | |
| C02838 | BRD-K70330032 | JNJ-42165279 | FAAH | FAAH inhibitor | Details | |
| C02839 | BRD-K83547600 | JNJ-47965567 | P2RX7 | purinergic receptor antagonist | Details | |
| C02840 | BRD-K19482962 | JNJ-63533054 | GPR139 | G protein-coupled receptor agonist | Details | |
| C02841 | BRD-K11636097 | JNJ-7706621 | AURKA|AURKB|CDK1|CDK2 | CDK inhibitor | Details | |
| C02842 | BRD-K17774839 | JNJ-7777120 | HRH4 | histamine receptor antagonist | Details | |
| C02843 | BRD-K25837718 | josamycin | bacterial 50S ribosomal subunit inhibitor | Details | ||
| C02844 | BRD-K54606188 | JQ1-(+) | BRD4|BRDT | bromodomain inhibitor | Details | |
| C02845 | BRD-K17705806 | JTC-801 | OPRL1 | opioid receptor antagonist | Details | |
| C02846 | BRD-K43330982 | JTE-013 | P2RY10|S1PR2 | lysophospholipid receptor antagonist | Details | |
| C02847 | BRD-K81405859 | JTE-607 | IL10|IL1B|IL6|TNF | cytokine production inhibitor | Details | |
| C02848 | BRD-K63150726 | JTE-907 | CNR2 | cannabinoid receptor inverse agonist | Details | |
| C02849 | BRD-K53328210 | JW-55 | TNKS|TNKS2 | tankyrase inhibitor | Details | |
| C02850 | BRD-K48424871 | JW-642 | MGLL | monoacylglycerol lipase inhibitor | Details | |
| C02851 | BRD-K24554037 | JW-67 | APC|AXIN1|GSK3B | Wnt pathway inhibitor | Details | |
| C02852 | BRD-K75664313 | JW-74 | TNKS|TNKS2 | WNT signaling inhibitor; tankyrase inhibitor | Details | |
| C02853 | BRD-K05464208 | JX-401 | MAPK14 | p38 MAPK inhibitor | Details | |
| C02854 | BRD-K45446451 | JZL-184 | MGLL | monoacylglucerol lipase inhibitor | Details | |
| C02855 | BRD-K38875233 | JZL-195 | FAAH|MGLL | FAAH inhibitor; monoacylglycerol lipase inhibitor | Details | |
| C02856 | BRD-A45906415 | K-MAP | Details | |||
| C02857 | BRD-K90756851 | K-Ras(G12C)-inhibitor-12 | KRAS | K-ras inhibitor | Details | |
| C02858 | BRD-K26305185 | K-Ras(G12C)-inhibitor-6 | K-ras inhibitor | Details | ||
| C02859 | BRD-A55312468 | k-strophanthidin | ATP1A1 | ATPase inhibitor | Details | |
| C02860 | BRD-A74648924 | K-247 | Details | |||
| C02861 | BRD-A67748489 | K-858 | KIF11 | kinesin-like spindle protein inhibitor | Details | |
| C02862 | BRD-K12807006 | kaempferol | AKR1B1|ALOX15B|ALOX5|AR|CYP1B1|GLO1|HSD17B1|UGT3A1 | bone resorption inhibitor; estrogen-related receptor inverse agonist | Details | |
| C02863 | BRD-K52459018 | kainic-acid | GRIA1|GRIK1|GRIK2|GRIK3|GRIK4|GRIK5 | kainate receptor agonist | Details | |
| C02864 | BRD-A07815743 | kakonein | GABA receptor antagonist; serotonin receptor antagonist | Details | ||
| C02865 | BRD-K08327065 | kanamycin | bacterial 30S ribosomal subunit inhibitor | Details | ||
| C02866 | BRD-K27584835 | kartogenin | FLNA | chondrocyte differentiation stimulator | Details | |
| C02867 | BRD-K17743697 | KB-R7943 | SLC8A1|TRPC3|TRPC5|TRPC6 | sodium/calcium exchange inhibitor | Details | |
| C02868 | BRD-K88154110 | KB-SRC-4 | SRC | src inhibitor | Details | |
| C02869 | BRD-A00376169 | KBG | MME | neprilysin inhibitor | Details | |
| C02870 | BRD-K71164191 | KD-023 | ACACA|ACACB | ACAT inhibitor | Details | |
| C02871 | BRD-K88506063 | KD025 | ROCK2 | rho associated kinase inhibitor | Details | |
| C02872 | BRD-K37312348 | kenpaullone | CCNB1|CDK1|CDK5|GSK3B | CDK inhibitor; glycogen synthase kinase inhibitor | Details | |
| C02873 | BRD-K49671696 | ketanserin | ADRA1A|ADRA1B|ADRA1D|DRD1|DRD5|HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C|HTR5A|HTR7|SLC18A1|SLC18A2 | serotonin receptor antagonist | Details | |
| C02874 | BRD-K29113274 | ketoconazole | AR|CYP19A1|CYP21A2|KCNA10 | sterol demethylase inhibitor | Details | |
| C02875 | BRD-A97739905 | ketoprofen | CXCR1|PTGS1|PTGS2|SLC5A8 | cyclooxygenase inhibitor | Details | |
| C02876 | BRD-A40639672 | ketorolac | PTGS1|PTGS2 | cyclooxygenase inhibitor | Details | |
| C02877 | BRD-K28936863 | ketotifen | HRH1|PDE4A|PDE4B|PDE4C|PDE4D|PDE7A|PDE7B|PDE8A|PDE8B|PGD | histamine receptor agonist; leukotriene receptor antagonist; phosphodiesterase inhibitor | Details | |
| C02878 | BRD-K61339991 | kevetrin | p53 activator | Details | ||
| C02879 | BRD-A54927599 | KF-38789 | SELP | P selectin inhibitor | Details | |
| C02880 | BRD-K90747162 | KG-5 | BRAF|FLT3|KIT|PDGFRB | RAF inhibitor | Details | |
| C02881 | BRD-K01673854 | KH-CB19 | CLK1|CLK3|DYRK1A | CDC inhibitor | Details | |
| C02882 | BRD-K80353807 | khellin | vasodilator | Details | ||
| C02883 | BRD-K84605263 | KHK-IN-1 | KHK | hexokinase inhibitor | Details | |
| C02884 | BRD-K78978711 | KHS-101 | TACC3 | neural stem cell inducer | Details | |
| C02885 | BRD-A25569250 | KI-16425 | LPAR1|LPAR3 | lysophosphatidic acid receptor antagonist | Details | |
| C02886 | BRD-A88787317 | KI-20227 | CSF1R|KDR|KIT|PDGFRB | c-Fms inhibitor | Details | |
| C02887 | BRD-K47150025 | KI-8751 | KDR | KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor | Details | |
| C02888 | BRD-K02898090 | kifunensine | MAN1B1|MAN2A1 | mannosidase inhibitor | Details | |
| C02889 | BRD-K65667145 | kinetin | cell division inducer | Details | ||
| C02890 | BRD-A94323479 | ki16198 | LPA | lipoprotein antagonist | Details | |
| C02891 | BRD-A94580299 | KL-001 | CRY1|CRY2 | proteasome inhibitor | Details | |
| C02892 | BRD-K46734292 | KML29 | MGLL | monoacylglucerol lipase inhibitor | Details | |
| C02893 | BRD-A81177136 | KN-62 | AKT1|CAMK2A|CHEK1|LCK|MAPK1|MAPK11|MAPK12|MAPK14|MAPK8|P2RX7|PRKCA|ROCK1|RPS6KB1|SGK1 | calcium/calmodulin dependent protein kinase inhibitor; purinergic receptor antagonist | Details | |
| C02894 | BRD-K93480852 | KN-93 | CAMK2A | calcium/calmodulin dependent protein kinase inhibitor | Details | |
| C02895 | BRD-K64642496 | Ko143 | ABCB1|ABCC1 | BCRP inhibitor | Details | |
| C02896 | BRD-K46690591 | KP-1212 | Details | |||
| C02897 | BRD-K71467466 | KPT-185 | XPO1 | exportin antagonist | Details | |
| C02898 | BRD-K75352575 | KPT-276 | XPO1 | exportin antagonist | Details | |
| C02899 | BRD-K40604024 | KRCA-0008 | ALK | ALK inihibitor | Details | |
| C02900 | BRD-K90993449 | KRN-633 | FLT1|FLT4|KDR | VEGFR inhibitor | Details |