CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C05901 | BRD-K11373525 | ZD-7155 | AGTR1 | angiotensin receptor antagonist | Details | |
| C05902 | BRD-K18678457 | ZD-7288 | HCN1|HCN2|HCN3|HCN4 | HCN channel blocker | Details | |
| C05903 | BRD-K90033078 | zeatin | Details | |||
| C05904 | BRD-K87714311 | zebularine | CDA|DNMT1 | DNA methyltransferase inhibitor | Details | |
| C05905 | BRD-K31553034 | zibotentan | EDNRA | endothelin receptor antagonist | Details | |
| C05906 | BRD-K72903603 | zidovudine | TERT | nucleoside reverse transcriptase inhibitor | Details | |
| C05907 | BRD-A56359832 | zileuton | ALOX5 | leukotriene synthesis inhibitor; lipoxygenase inhibitor | Details | |
| C05908 | BRD-K42816473 | zilpaterol | ADRB2 | adrenergic receptor agonist | Details | |
| C05909 | BRD-K46914825 | zimelidine | MAOA|MAOB|SLC6A4 | selective serotonin reuptake inhibitor (SSRI) | Details | |
| C05910 | BRD-K13330768 | zinc-undecylenate | other antifungal | Details | ||
| C05911 | BRD-K26598477 | zindotrine | phosphodiesterase inhibitor | Details | ||
| C05912 | BRD-K29582115 | ziprasidone | ADRA1A|ADRA1B|ADRA2A|ADRA2B|ADRA2C|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HTR1A|HTR1B|HTR1D|HTR1E|HTR2A|HTR2C|HTR3A|HTR6|HTR7|SLC6A4 | dopamine receptor antagonist; serotonin receptor antagonist | Details | |
| C05913 | BRD-K05151076 | ZK-164015 | ESR1|ESR2 | estrogen receptor antagonist | Details | |
| C05914 | BRD-K67525671 | ZK-200775 | kainate receptor antagonist | Details | ||
| C05915 | BRD-K33882852 | ZK-93423 | GABRA1|GABRA2|GABRA3|GABRA5|GABRB2|GABRG2 | benzodiazepine receptor agonist | Details | |
| C05916 | BRD-K68392338 | ZK-93426 | GABRA1|GABRA2|GABRA3|GABRA5 | benzodiazepine receptor antagonist | Details | |
| C05917 | BRD-K91825936 | ZK811752 | CCR1 | CC chemokine receptor antagonist | Details | |
| C05918 | BRD-K64103579 | ZLN-024 | PRKAA1|PRKAB1|PRKAG1 | AMPK activator | Details | |
| C05919 | BRD-K73073971 | ZLN005 | Details | |||
| C05920 | BRD-A62209527 | ZM-226600 | Kir6 channel (KATP) activator | Details | ||
| C05921 | BRD-K19605405 | ZM-241385 | ADORA1|ADORA2A|ADORA2B|ADORA3 | adenosine receptor antagonist | Details | |
| C05922 | BRD-K41337261 | ZM-306416 | EGFR|FLT1|FLT4|KDR | Abl kinase inhibitor; src inhibitor; VEGFR inhibitor | Details | |
| C05923 | BRD-K67831364 | ZM-323881 | KDR | VEGFR inhibitor | Details | |
| C05924 | BRD-K73789395 | ZM-336372 | BRAF|LCK|MAPK14|RAF1 | RAF inhibitor | Details | |
| C05925 | BRD-K40624912 | ZM-39923 | JAK1|JAK3 | JAK inhibitor | Details | |
| C05926 | BRD-K72703948 | ZM-447439 | AURKA|AURKB | Aurora kinase inhibitor | Details | |
| C05927 | BRD-K46654563 | zofenopril-calcium | ACE | angiotensin converting enzyme inhibitor | Details | |
| C05928 | BRD-K08996725 | zolantidine | histamine receptor antagonist | Details | ||
| C05929 | BRD-K84253429 | zoledronic-acid | FDPS|GGPS1 | bone resorption inhibitor | Details | |
| C05930 | BRD-K45125084 | zolimidine | mucus protecting agent | Details | ||
| C05931 | BRD-K54314721 | zolmitriptan | HTR1A|HTR1B|HTR1D|HTR1E|HTR1F | serotonin receptor agonist | Details | |
| C05932 | BRD-K44876623 | zolpidem | GABRA1|GABRA2|GABRA3 | benzodiazepine receptor agonist | Details | |
| C05933 | BRD-K81326768 | zomepirac | PTGDR2 | prostaglandin synthesis inhibitor | Details | |
| C05934 | BRD-K14571191 | zometapine | Details | |||
| C05935 | BRD-K43992824 | zoniporide | SLC9A1 | sodium/hydrogen exchanger inhibitor | Details | |
| C05936 | BRD-K48300629 | zonisamide | CA1|CA10|CA11|CA12|CA13|CA14|CA2|CA3|CA4|CA5A|CA5B|CA6|CA7|CA8|CA9|CACNA1G|CACNA1H|CACNA1I|MAOA|MAOB|SCN10A|SCN11A|SCN1A|SCN1B|SCN2A|SCN2B|SCN3A|SCN3B|SCN4A|SCN4B|SCN5A|SCN7A|SCN8A|SCN9A | sodium channel blocker; T-type calcium channel blocker | Details | |
| C05937 | BRD-K84459715 | zopolrestat | Details | |||
| C05938 | BRD-K70557564 | zosuquidar | ABCB1|ABCB4 | P glycoprotein inhibitor | Details | |
| C05939 | BRD-K46843573 | zotarolimus | FKBP1A | mTOR inhibitor | Details | |
| C05940 | BRD-K64557645 | zotepine | ADRA2B|DRD2|DRD3|DRD4|HRH1|HTR1A|HTR1B|HTR1D|HTR1E|HTR2A|HTR2C|HTR6|HTR7|SLC6A2|SLC6A4 | dopamine receptor antagonist; serotonin receptor antagonist | Details | |
| C05941 | BRD-K66353228 | zoxazolamine | myorelaxant | Details | ||
| C05942 | BRD-K63068307 | ZSTK-474 | PIK3CB|PIK3CD|PIK3CG | PI3K inhibitor | Details | |
| C05943 | BRD-K28761384 | zuclopenthixol | ADRA1A|ADRA2A|DRD1|DRD2|DRD5|HRH1|HTR2A | dopamine receptor antagonist | Details | |
| C05944 | BRD-K16037980 | Z160 | CACNA2D1 | N-type calcium channel blocker | Details | |
| C05945 | BRD-K04603573 | 1,12-Besm | polyamine biosynthesis inhibitor | Details | ||
| C05946 | BRD-K06817181 | 1,2,3,4,5,6-hexabromocyclohexane | JAK2 | JAK inhibitor | Details | |
| C05947 | BRD-K41853443 | 1,3-dipropyl-8-phenylxanthine | adenosine receptor antagonist | Details | ||
| C05948 | BRD-K22346679 | 1,4-butanediol | MAN1B1|PLA2G2A|PLA2G2E | benzodiazepine receptor agonist; gamma hydroxybutyric acid agonist | Details | |
| C05949 | BRD-K53083666 | 1,5-dicaffeoylquinic-acid | Details | |||
| C05950 | BRD-K88956297 | 1-((Z)-3-Chloroallyl)-1,3,5,7-tetraazaadamantan-1-ium | Details | |||
| C05951 | BRD-A86415025 | 1-(1,2-Diphenylethyl)piperidine-(+/-) | glutamate receptor antagonist | Details | ||
| C05952 | BRD-A95802703 | 1-(2-chloro-5-methylphenoxy)-3-(isopropylamino)-2-propanol | Details | |||
| C05953 | BRD-K96055017 | 1-acetyl-4-methylpiperazine | acetylcholine receptor agonist | Details | ||
| C05954 | BRD-K03273112 | 1-azakenpaullone | CCNB1|CDK1|CDK5|GSK3B | glycogen synthase kinase inhibitor | Details | |
| C05955 | BRD-K89665618 | 1-deoxymannojirimycin | MAN2A1 | alpha mannosidase inhibitor | Details | |
| C05956 | BRD-K70586315 | 1-EBIO | KCNN1|KCNN2|KCNN3|KCNN4 | potassium channel activator | Details | |
| C05957 | BRD-K08288352 | 1-ethyl-2-pyrrolidone | transdermal absorption-enhancing compound | Details | ||
| C05958 | BRD-K35114608 | 1-hexadecanal | DBI|RHO | sphingosine 1 phosphate receptor substrate | Details | |
| C05959 | BRD-K37203094 | 1-hexadecanol | Details | |||
| C05960 | BRD-K29542628 | 1-naphthyl-PP1 | SRC | src inhibitor | Details | |
| C05961 | BRD-K03083257 | 1-octacosanol | Details | |||
| C05962 | BRD-K09338665 | 1-octanol | GJA1|GJA10|GJA3|GJA4|GJA5|GJA8|GJA9|GJB1|GJB2|GJB3|GJB4|GJB5|GJB6|GJB7|GJC1|GJC2|GJC3|GJD2|GJD3|GJD4|GJE1 | Details | ||
| C05963 | BRD-K31491153 | 1-phenylbiguanide | HTR3A|HTR3B | serotonin receptor agonist | Details | |
| C05964 | BRD-A37752546 | 1E-1-(2-hydroxy-5-methylphenyl)-1-dodecanone oxime | Details | |||
| C05965 | BRD-K27853494 | 1s,2r-phenylpropanolamine | ADRA1A|ADRA2A|ADRB1|ADRB2|DRD1 | adrenergic receptor agonist | Details | |
| C05966 | BRD-K96631475 | 10-deacetylbaccatin | antitumor agent | Details | ||
| C05967 | BRD-K70792160 | 10-DEBC | PIM1 | AKT inhibitor | Details | |
| C05968 | BRD-K63784565 | 10-hydroxycamptothecin | TOP1 | topoisomerase inhibitor | Details | |
| C05969 | BRD-K49460120 | 10058-F4 | c-Myc inhibitor | Details | ||
| C05970 | BRD-K68552125 | 12-O-tetradecanoylphorbol-13-acetate | KCNT2|TRPV4 | PKC activator | Details | |
| C05971 | BRD-K30237152 | 1400W | NOS1|NOS2|NOS3 | nitric oxide synthase inhibitor | Details | |
| C05972 | BRD-K92301463 | 16,16-dimethylprostaglandin-e2 | HPGD | prostanoid receptor agonist | Details | |
| C05973 | BRD-K84036904 | 17-alpha-methyltestosterone | AR | aromatase inhibitor | Details | |
| C05974 | BRD-A29731977 | 17-hydroxyprogesterone-caproate | AR|ESR1|ESR2|NR1H4|NR1I2|NR3C1|PGR | progesterone receptor agonist | Details | |
| C05975 | BRD-K07395323 | 17-PA | glucocorticoid receptor agonist | Details | ||
| C05976 | BRD-K78092779 | 2'-c-methylguanosine | HCV inhibitor | Details | ||
| C05977 | BRD-K63932022 | 2'-MeCCPA | ADORA1 | adenosine receptor agonist | Details | |
| C05978 | BRD-K44602126 | 2,3-cis/exo-camphanediol | Details | |||
| C05979 | BRD-A75263867 | 2,3-cis/exo-pinanediol | Details | |||
| C05980 | BRD-K61734568 | 2,3-DCPE | BCL2L1 | Bcl-XL downregulator | Details | |
| C05981 | BRD-K97833335 | 2,4-dinitrochlorobenzene | TXN | thioredoxin inhibitor | Details | |
| C05982 | BRD-K21910317 | 2,4-dinitrophenol | APP | ATP synthase inhibitor | Details | |
| C05983 | BRD-K29791386 | 2,5-furandimethanol | HBB | hemoglobin modulator | Details | |
| C05984 | BRD-A21276153 | 2,6-dimethylpiperidine | Details | |||
| C05985 | BRD-K46989997 | 2-(chloromethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | Details | |||
| C05986 | BRD-A66788520 | 2-(3-mercaptopropyl)pentanedioic acid | FOLH1 | glutamate carboxypeptidase inhibitor | Details | |
| C05987 | BRD-K91868854 | 2-[1-(4-piperonyl)piperazinyl]benzothiazole | HTR4 | serotonin receptor agonist | Details | |
| C05988 | BRD-K32681104 | 2-aminobenzenesulfonamide | CA12|CA14|CA2|CA6|CA9 | carbonic anhydrase inhibitor | Details | |
| C05989 | BRD-K13346085 | 2-APB | TRPC1|TRPC3|TRPC4|TRPC5|TRPC6|TRPC7|TRPM2|TRPM3|TRPM6|TRPV1|TRPV6 | 1,4,5-trisphosphate inhibitor | Details | |
| C05990 | BRD-K22745370 | 2-BFI | ADRA2A|ADRA2B|ADRA2C|MAOA|MAOB | imidazoline receptor ligand | Details | |
| C05991 | BRD-K70088346 | 2-chloro-N6-cyclopentyladenosine | ADORA1|ADORA2A|ADORA2B|ADORA3 | adenosine receptor agonist | Details | |
| C05992 | BRD-K79511609 | 2-chloroadenosine | ADORA1|ADORA2A|ADORA2B | adenosine receptor agonist | Details | |
| C05993 | BRD-K84075000 | 2-Chloropyrazine | Details | |||
| C05994 | BRD-K92588747 | 2-CMDO | DRD2|DRD4 | dopamine receptor antagonist | Details | |
| C05995 | BRD-K95015809 | 2-cyanopyrimidine | cathepsin inhibitor | Details | ||
| C05996 | BRD-A55902763 | 2-Deoxy-2-{[methyl(nitroso)carbamoyl]amino}hexose | Details | |||
| C05997 | BRD-K97808269 | 2-deoxyglucose | SLC2A1|SLC2A2|SLC2A3|SLC2A4 | glycolysis inhibitor | Details | |
| C05998 | BRD-K04843302 | 2-ethoxybenzoic-acid | analgesic agent | Details | ||
| C05999 | BRD-A55455283 | 2-ethyl-1,3-hexanediol | Details | |||
| C06000 | BRD-A53037300 | 2-fluoro-2-deoxy-D-galactose | LCT | Details |