CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C05801 | BRD-K08223200 | WAY-200070 | ERBB2|ERBB3|ERBB4|ESR2 | estrogen receptor agonist | Details | |
| C05802 | BRD-K08657056 | WAY-207024 | GNRHR|HRH2|TACR2 | gonadotropin releasing factor hormone receptor antagonist | Details | |
| C05803 | BRD-K63483542 | WAY-208466 | DRD2|HTR2A|HTR2C|HTR6|HTR7 | serotonin receptor agonist | Details | |
| C05804 | BRD-K96758128 | WAY-213613 | SLC1A2 | glutamate inhibitor | Details | |
| C05805 | BRD-K61871885 | WAY-316606 | SFRP1 | secreted frizzled related protein inhibitor | Details | |
| C05806 | BRD-K54640016 | WAY-362450 | NR1H4 | FXR agonist | Details | |
| C05807 | BRD-K85920262 | WAY-600 | MTOR | mTOR inhibitor | Details | |
| C05808 | BRD-K55430733 | WAY-629 | HTR2C | serotonin receptor agonist | Details | |
| C05809 | BRD-A01493904 | WB-4101 | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|HTR1A | adrenergic receptor antagonist | Details | |
| C05810 | BRD-K47726410 | WDR5-0103 | WDR5 | histone lysine methyltransferase inhibitor | Details | |
| C05811 | BRD-K55487946 | WEHI-345-analog | src inhibitor | Details | ||
| C05812 | BRD-K50199947 | WH-4-023 | LCK|SRC | src inhibitor | Details | |
| C05813 | BRD-K07487750 | WHI-P154 | EGFR|JAK1|JAK2|JAK3 | JAK inhibitor | Details | |
| C05814 | BRD-K19316653 | WIKI4 | TNKS2 | Wnt pathway inhibitor; tankyrase inhibitor | Details | |
| C05815 | BRD-K30930903 | WIN-18446 | ALDH1A2 | aldehyde dehydrogenase inhibitor | Details | |
| C05816 | BRD-K22662557 | WIN-64338 | BDKRB2 | bradykinin receptor antagonist | Details | |
| C05817 | BRD-A18579359 | wiskostatin | WAS|WASL | neural Wiskott-Aldrich syndrome protein inhibitor; actin related protein inhibitor | Details | |
| C05818 | BRD-K78455053 | wnt-c59 | PORCN | porcupine inhibitor | Details | |
| C05819 | BRD-K87343924 | wortmannin | PI4KA|PI4KB|PIK3CA|PIK3CD|PIK3CG|PIK3R1|PLK1|PRKDC | PI3K inhibitor | Details | |
| C05820 | BRD-K05445342 | WP1066 | STAT3 | STAT inhibitor | Details | |
| C05821 | BRD-K43644456 | WP1130 | JAK2|UCHL5|USP14|USP9X | deubiquitinase inhibitor | Details | |
| C05822 | BRD-K45973863 | WR99210 | TYMS | dihydrofolate reductase inhibitor | Details | |
| C05823 | BRD-K49389158 | WWL-113 | CES3 | carboxylesterase inhibitor | Details | |
| C05824 | BRD-K83176916 | WWL-123 | ABHD6 | monoacylglycerol lipase inhibitor | Details | |
| C05825 | BRD-K43419711 | Wy-16922 | histamine release inhibitor | Details | ||
| C05826 | BRD-A45498368 | WYE-125132 | MTOR | mTOR inhibitor | Details | |
| C05827 | BRD-K77008974 | WYE-354 | MTOR | mTOR inhibitor | Details | |
| C05828 | BRD-K49900195 | WYE-687 | MTOR | mTOR inhibitor | Details | |
| C05829 | BRD-K73293050 | WZ-3146 | EGFR | EGFR inhibitor | Details | |
| C05830 | BRD-K72420232 | WZ-4002 | EGFR|ERBB2 | EGFR inhibitor | Details | |
| C05831 | BRD-K45909031 | WZ4003 | NUAK1|NUAK2 | AMPK inhibitor | Details | |
| C05832 | BRD-K81728688 | WZ8040 | EGFR | EGFR inhibitor | Details | |
| C05833 | BRD-K25359048 | WZ811 | CXCR4 | CC chemokine receptor antagonist | Details | |
| C05834 | BRD-K88358234 | xaliproden | HTR1A | serotonin receptor agonist | Details | |
| C05835 | BRD-A59337442 | xamoterol | ADRB1 | adrenergic receptor agonist | Details | |
| C05836 | BRD-K72815923 | xanomeline | CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR6|HTR7 | acetylcholine receptor agonist | Details | |
| C05837 | BRD-K27135764 | xanthone | antimalarial agent | Details | ||
| C05838 | BRD-K12762134 | XAV-939 | TNKS|TNKS2 | tankyrase inhibitor | Details | |
| C05839 | BRD-K45875383 | XBD173 | TSPO | benzodiazepine receptor ligand | Details | |
| C05840 | BRD-K69211575 | XD-14 | BRD2|BRD3|BRD4|BRDT | bromodomain inhibitor | Details | |
| C05841 | BRD-K42748308 | XE-991 | KCNQ1|KCNQ2|KCNQ3|KCNQ4|KCNQ5 | potassium channel blocker | Details | |
| C05842 | BRD-K99506538 | xenalipin | Details | |||
| C05843 | BRD-A21446384 | xibenolol | adrenergic receptor antagonist | Details | ||
| C05844 | BRD-K79633074 | xilobam | Details | |||
| C05845 | BRD-K27393415 | xipamide | SLC12A3 | carbonic anhydrase inhibitor | Details | |
| C05846 | BRD-K95901403 | XL-147 | PIK3CA|PIK3CD|PIK3CG | PI3K inhibitor | Details | |
| C05847 | BRD-K03765900 | XL-647 | EGFR|EPHB4|ERBB2|FLT4|KDR | EGFR inhibitor; VEGFR inhibitor | Details | |
| C05848 | BRD-K04266228 | XL019 | JAK1|JAK2|JAK3 | JAK inhibitor | Details | |
| C05849 | BRD-K14274271 | XL228 | IGF1R|SRC | Abl kinase inhibitor; insulin growth factor receptor inhibitor; src inhibitor | Details | |
| C05850 | BRD-K03549949 | XL388 | MTOR | mTOR inhibitor | Details | |
| C05851 | BRD-A03506276 | XL888 | HSP inhibitor | Details | ||
| C05852 | BRD-K48449981 | XMD17-109 | MAPK7 | MAP kinase inhibitor | Details | |
| C05853 | BRD-K50387473 | XMD8-92 | DCLK2|MAPK7|PLK4|TNK1 | MAP kinase inhibitor | Details | |
| C05854 | BRD-K21565985 | xylazine | ADRA2A|ADRA2B|ADRA2C | adrenergic receptor agonist | Details | |
| C05855 | BRD-K08356259 | xylometazoline | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C | adrenergic receptor agonist | Details | |
| C05856 | BRD-K10759144 | xylose | Details | |||
| C05857 | BRD-K09317629 | Y-11 | PTK2 | focal adhesion kinase inhibitor | Details | |
| C05858 | BRD-K94832621 | Y-134 | ESR1|ESR2 | estrogen receptor antagonist | Details | |
| C05859 | BRD-K45117373 | Y-26763 | KCNJ8 | potassium channel activator | Details | |
| C05860 | BRD-K42679050 | Y-27152 | KCNJ8 | potassium channel activator | Details | |
| C05861 | BRD-K44084986 | Y-27632 | PKIA|PKN2|PRKACA|PRKCE|ROCK1|ROCK2 | rho associated kinase inhibitor | Details | |
| C05862 | BRD-K48449073 | Y-29794 | PREP | prolyl endopeptidase inhibitor | Details | |
| C05863 | BRD-K96259238 | Y-320 | IL17A | interleukin inhibitor | Details | |
| C05864 | BRD-K56751279 | Y-39983 | ROCK1|ROCK2 | rho associated kinase inhibitor | Details | |
| C05865 | BRD-K60476892 | YC-1 | GUCY1A2|GUCY1A3|GUCY1B3|HIF1A | guanylyl cyclase activator | Details | |
| C05866 | BRD-K91403886 | YIL-781 | GHSR | ghrelin receptor antagonist | Details | |
| C05867 | BRD-A62182663 | YK-4-279 | EWSR1|FLI1 | apoptosis inhibitor | Details | |
| C05868 | BRD-K76703230 | YM-155 | BIRC5 | survivin inhibitor | Details | |
| C05869 | BRD-K48488978 | YM-201636 | PI3K inhibitor | Details | ||
| C05870 | BRD-K52087522 | YM-244769 | sodium/calcium exchange inhibitor | Details | ||
| C05871 | BRD-K59650319 | YM-298198 | GRM1 | glutamate receptor antagonist | Details | |
| C05872 | BRD-K38398115 | YM-511 | CYP19A1 | aromatase inhibitor | Details | |
| C05873 | BRD-K42563464 | YM-58483 | TRPC3|TRPC5|TRPM4 | calcium channel blocker | Details | |
| C05874 | BRD-K91716465 | YM-750 | SOAT1 | ACAT inhibitor | Details | |
| C05875 | BRD-K06712146 | YM-90709 | CSF2RB|IL5RA | IL5 inhibitor | Details | |
| C05876 | BRD-K12932420 | YM-976 | PDE4A | phosphodiesterase inhibitor | Details | |
| C05877 | BRD-K09436144 | YM022 | CCKBR | CCK receptor antagonist | Details | |
| C05878 | BRD-K04622161 | YO-01027 | gamma secretase inhibitor | Details | ||
| C05879 | BRD-K88570498 | yoda-1 | PIEZO1 | piezo channel activator | Details | |
| C05880 | BRD-K35586044 | yohimbine | ADRA2A|ADRA2B|ADRA2C|DRD2|DRD3|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR5A|HTR7|KCNJ1|KCNJ10|KCNJ11|KCNJ12|KCNJ14|KCNJ15|KCNJ8 | adrenergic receptor antagonist | Details | |
| C05881 | BRD-K06208435 | YS-035 | calcium channel blocker | Details | ||
| C05882 | BRD-K53438416 | YZ9 | MIF|PFKFB3 | phosphofructokinase inhibitor | Details | |
| C05883 | BRD-K81865756 | Y16 | RHOA | rho associated kinase inhibitor | Details | |
| C05884 | BRD-A65615053 | zacopride | HTR3A|HTR3B|HTR4|HTR5A | serotonin receptor antagonist | Details | |
| C05885 | BRD-K71289571 | zafirlukast | CYSLTR1|CYSLTR2 | leukotriene receptor antagonist | Details | |
| C05886 | BRD-K85925969 | zalcitabine | nucleoside reverse transcriptase inhibitor | Details | ||
| C05887 | BRD-A26032986 | zaldaride | CALM1 | calmodulin antagonist | Details | |
| C05888 | BRD-K92657060 | zaleplon | GABRA1|GABRB1|GABRG2|TSPO | benzodiazepine receptor agonist | Details | |
| C05889 | BRD-K12261274 | zaltidine | HRH2 | histamine receptor antagonist | Details | |
| C05890 | BRD-A00578795 | zaltoprofen | cyclooxygenase inhibitor | Details | ||
| C05891 | BRD-K11984358 | ZAMI-633 | urease inhibitor | Details | ||
| C05892 | BRD-K80451230 | zamifenacin | CHRM3 | acetylcholine receptor antagonist | Details | |
| C05893 | BRD-K23067689 | zanamivir | NEU2 | neuraminidase inhibitor | Details | |
| C05894 | BRD-K44825564 | ZAPA | Details | |||
| C05895 | BRD-K16542329 | zaprinast | GPR35|PDE1A|PDE4D|PDE5A|PDE9A | phosphodiesterase inhibitor | Details | |
| C05896 | BRD-K37561857 | zardaverine | PDE4D | phosphodiesterase inhibitor | Details | |
| C05897 | BRD-K92446736 | zatebradine | HCN1|HCN2|HCN3|HCN4 | HCN channel blocker | Details | |
| C05898 | BRD-K22829793 | ZCL-278 | CDC42 | CDC inhibitor | Details | |
| C05899 | BRD-K64157027 | ZD-2079 | ADRB3 | adrenergic receptor agonist | Details | |
| C05900 | BRD-K28971625 | ZD-7114 | ADRB3 | adrenergic receptor agonist | Details |