CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C00101 | BRD-K32318651 | acyclovir | PNP | DNA polymerase inhibitor | Details | |
| C00102 | BRD-K10226125 | AC1NDSS5 | Details | |||
| C00103 | BRD-A80280426 | AD-5467 | AKR1B1 | aldose reductase inhibitor | Details | |
| C00104 | BRD-K33127281 | adapalene | RARA|RARB|RARG|RXRA|RXRB|RXRG | retinoid receptor agonist | Details | |
| C00105 | BRD-A73427433 | adaprev | IGF2R|M6PR | TGF beta receptor inhibitor | Details | |
| C00106 | BRD-K37151368 | adaptavir | CCR5 | CC chemokine receptor antagonist | Details | |
| C00107 | BRD-K00152668 | adarotene | RARB|RARG | retinoid receptor agonist | Details | |
| C00108 | BRD-K67789209 | adatanserin | HTR1A|HTR2A | serotonin receptor agonist; serotonin receptor antagonist | Details | |
| C00109 | BRD-K43055376 | ADD-233089 | benzodiazepine receptor agonist | Details | ||
| C00110 | BRD-K77484724 | adefovir | DNA polymerase inhibitor | Details | ||
| C00111 | BRD-K96159438 | adefovir-dipivoxil | DNA polymerase inhibitor | Details | ||
| C00112 | BRD-K78097265 | adelmidrol | anti-inflammatory agent | Details | ||
| C00113 | BRD-K78185697 | ademetionine | AMD1|CBS|COMT|GNMT|MAT1A|MAT2A | methyltransferase stimulant; phosphodiesterase inhibitor | Details | |
| C00114 | BRD-K26060080 | adenine | ACACB|ACP1|APRT|MTAP|PECR|SRPK2 | protein synthesis stimulant | Details | |
| C00115 | BRD-K01577834 | adenosine | ADORA1|ADORA2A|ADORA2B|ADORA3|PI4K2A|PI4K2B|TRPM4 | adenosine receptor agonist | Details | |
| C00116 | BRD-A10111329 | adenosine-phosphate | ACSL1|ACSS1|ACSS2|ADCY1|ADK|CREB1|FBP1|HINT1|PDE4B|PDE4D|PIM1|PRKAA1|PRKAB1|PRKAB2|PYGL|TRPM4 | adenosine receptor agonist | Details | |
| C00117 | BRD-A31990649 | adenosine-triphosphate | ABCA1|ABCB1|ABCB11|ABCC2|ABCC8|ABCC9|ABCG1|ABL1|ABL2|ACSL1|ACSS1|ACSS2|ACVR1|ACVR1B|ACVRL1|ADCY1|ADRBK1|ADRBK2|AFG3L2|AKT1|ALK|AMHR2|APAF1|ARAF|ASNA1|ASNS|ASS1|CDK15|GPR17|ITPR1|NAE1|NT5C2|P2RY1|P2RY11|P2RY13|P2RY2|P2RY4|PRKAA1|RYR1|RYR2|RYR3|SLC25A4|TNK2|TRPM4|TRPM7 | adenosine receptor agonist | Details | |
| C00118 | BRD-K60907894 | adiphenine | CHRNA1 | acetylcholine receptor antagonist | Details | |
| C00119 | BRD-K10656395 | adipic-acid | SLC22A6 | solute carrier family member inhibitor | Details | |
| C00120 | BRD-K68810443 | adiporon | ADIPOR1|ADIPOR2 | adiponectin receptor agonist | Details | |
| C00121 | BRD-K39624409 | ADL5859 | OPRD1 | opioid receptor agonist | Details | |
| C00122 | BRD-K34870043 | adoprazine | DRD2|HTR1A | dopamine receptor antagonist; serotonin receptor agonist | Details | |
| C00123 | BRD-A90926615 | adrafinil | adrenergic receptor agonist | Details | ||
| C00124 | BRD-K82343404 | adrenalone | ADRA1A | adrenergic receptor agonist | Details | |
| C00125 | BRD-K17368287 | adrenosterone | HSD11B1|HSD11B2 | 11-beta hydroxysteroid dehydrogenase inhibitor | Details | |
| C00126 | BRD-K77911775 | ADX-10059 | GRM5 | glutamate receptor negative allosteric modulator | Details | |
| C00127 | BRD-K56543881 | ADX-47273 | GRM5 | glutamate receptor modulator | Details | |
| C00128 | BRD-K40718343 | AEE788 | EGFR|ERBB2|ERBB4|FGFR2|FGFR3|KDR | EGFR inhibitor; VEGFR inhibitor | Details | |
| C00129 | BRD-K77634909 | AEG3482 | HSP inducer | Details | ||
| C00130 | BRD-K53205568 | afalanine | DRD2 | dopamine receptor agonist | Details | |
| C00131 | BRD-K66175015 | afatinib | EGFR|ERBB2|ERBB4 | EGFR inhibitor | Details | |
| C00132 | BRD-K04210847 | afimoxifene | ESR1|ESR2|ESRRG|PLD1|PRKCD|PRKCE|PRKCQ|PRKCZ | estrogen receptor antagonist | Details | |
| C00133 | BRD-K69247067 | afloqualone | acetylcholine receptor antagonist | Details | ||
| C00134 | BRD-K23791635 | AFN-1252 | FABI inhibitor | Details | ||
| C00135 | BRD-K37793595 | afobazole | anxiolytic | Details | ||
| C00136 | BRD-K47816470 | AF38469 | SORT1 | sortilin inhibitor | Details | |
| C00137 | BRD-K08310154 | AG-1024 | IGF1R | insulin growth factor receptor inhibitor | Details | |
| C00138 | BRD-K00615600 | AG-14361 | PARP1 | PARP inhibitor | Details | |
| C00139 | BRD-K47105409 | AG-490 | EGFR|JAK2|JAK3 | EGFR inhibitor; JAK inhibitor | Details | |
| C00140 | BRD-K34428485 | AG-555 | CDK2 | tyrosine kinase inhibitor | Details | |
| C00141 | BRD-K81048131 | AG-556 | tyrosine kinase inhibitor | Details | ||
| C00142 | BRD-A56371469 | AGI-5198 | IDH1 | isocitrate dehydrogenase inhibitor | Details | |
| C00143 | BRD-K04691817 | AGI-6780 | IDH2 | isocitrate dehydrogenase inhibitor | Details | |
| C00144 | BRD-A78111609 | AGM-1470 | METAP2 | cell cycle inhibitor | Details | |
| C00145 | BRD-K49738308 | agmatine | ADRA2C|ASIC3|CACNA1B|CHRNA1|GRIN1|KCNJ1|NISCH | nitric oxide synthase inhibitor | Details | |
| C00146 | BRD-A18074780 | AGN-192403 | NISCH | imidazoline receptor ligand | Details | |
| C00147 | BRD-K70262971 | AGN-194310 | RXRA|RXRB|RXRG | retinoid receptor antagonist | Details | |
| C00148 | BRD-K32533226 | AGN-195183 | RARA | retinoid receptor agonist | Details | |
| C00149 | BRD-K84698278 | agomelatine | HTR2A|HTR2B|HTR2C|MTNR1A|MTNR1B | melatonin receptor agonist; serotonin receptor antagonist | Details | |
| C00150 | BRD-K91495480 | AGP-103 | membrane permeability inhibitor | Details | ||
| C00151 | BRD-K10852420 | AH-7614 | FFAR4 | free fatty acid receptor antagonist | Details | |
| C00152 | BRD-A64808605 | AH11110 | ADRA1B | adrenergic receptor ligand | Details | |
| C00153 | BRD-K59339270 | AH6809 | PTGDR|PTGER1|PTGER2|PTGER3 | prostanoid receptor antagonist | Details | |
| C00154 | BRD-K89899948 | AI-10-49 | CBFB | core binding factor inhibitor | Details | |
| C00155 | BRD-K85139301 | AIM-100 | TNK2 | tyrosine kinase inhibitor | Details | |
| C00156 | BRD-A48300215 | ajmaline | SCN5A | sodium channel blocker | Details | |
| C00157 | BRD-K76677554 | AJ76-(+) | DRD2|DRD3|DRD4 | dopamine receptor antagonist | Details | |
| C00158 | BRD-K09143580 | AK-7 | SIRT2 | SIRT inhibitor | Details | |
| C00159 | BRD-K54907283 | AKBA | ALOX5 | lipoxygenase inhibitor | Details | |
| C00160 | BRD-K26807903 | aklomide | Details | |||
| C00161 | BRD-K44731351 | AL-8697 | MAPK14 | p38 MAPK inhibitor | Details | |
| C00162 | BRD-K51784806 | alacepril | ACE | angiotensin converting enzyme inhibitor | Details | |
| C00163 | BRD-K80403280 | alafosfalin | bacterial cell wall synthesis inhibitor | Details | ||
| C00164 | BRD-K96029467 | alagebrium | glycosylation inhibitor | Details | ||
| C00165 | BRD-A33317514 | alanine | AARS|AARS2|ABAT|AGXT|AGXT2|GPRC6A|GPT|GPT2|KYNU|NFS1|PHYKPL|SLC1A4|SLC36A1|SLC7A8 | Details | ||
| C00166 | BRD-K53731810 | alantolactone | STAT3 | apoptosis stimulant; STAT inhibitor | Details | |
| C00167 | BRD-A14966924 | alaproclate | SLC6A4 | serotonin receptor antagonist | Details | |
| C00168 | BRD-K42140276 | alarelin | GNRH1 | gonadotropin releasing factor hormone receptor antagonist | Details | |
| C00169 | BRD-K79131256 | albendazole | TUBA1A|TUBB|TUBB4B | tubulin polymerization inhibitor | Details | |
| C00170 | BRD-A67060370 | albendazole-oxide | anthelmintic agent | Details | ||
| C00171 | BRD-A88254928 | albuterol | ADRB1|ADRB2 | adrenergic receptor agonist | Details | |
| C00172 | BRD-K55991142 | alcaftadine | HRH1 | histamine receptor antagonist | Details | |
| C00173 | BRD-K47492008 | alclofenac | PTGS1 | cyclooxygenase inhibitor | Details | |
| C00174 | BRD-A17407635 | alclometasone-dipropionate | CYP3A4|NR3C1|SERPINA6 | glucocorticoid receptor agonist | Details | |
| C00175 | BRD-A84907376 | alcuronium | CHRM1|CHRM2|CHRM3|CHRM4|CHRNA7 | muscle relaxant | Details | |
| C00176 | BRD-K06890060 | alda-1 | ALDH2 | aldehyde dehydrogenase activator | Details | |
| C00177 | BRD-K68928792 | aldoxorubicin | TOP2A | topoisomerase inhibitor | Details | |
| C00178 | BRD-K11267252 | alectinib | ALK|MET | ALK tyrosine kinase receptor inhibitor | Details | |
| C00179 | BRD-K75527158 | alendronate | ATP6V1A|FDPS|PTPN4|PTPRE|PTPRS | bone resorption inhibitor | Details | |
| C00180 | BRD-A27883417 | alexidine | PTPMT1 | phosphatidylglycerophosphatase inhibitor | Details | |
| C00181 | BRD-K49522529 | alfacalcidol | CYP27B1|VDR | vitamin D receptor agonist | Details | |
| C00182 | BRD-K51751936 | alfadolone-acetate | benzodiazepine receptor agonist | Details | ||
| C00183 | BRD-K41445866 | alfaxalone | GABBR1 | chloride channel agonist; benzodiazepine receptor agonist | Details | |
| C00184 | BRD-A09056319 | alfuzosin | ADRA1A|ADRA1B|ADRA1D|KCNH2 | adrenergic receptor antagonist | Details | |
| C00185 | BRD-A41774846 | algestone-acetophenide | Details | |||
| C00186 | BRD-K60102752 | alibendol | antispasmodic | Details | ||
| C00187 | BRD-A49225603 | alimemazine | HRH1 | histamine receptor agonist | Details | |
| C00188 | BRD-K75295174 | alisertib | AURKA | Aurora kinase inhibitor | Details | |
| C00189 | BRD-K30020243 | aliskiren-hemifumarate | REN | renin inhibitor | Details | |
| C00190 | BRD-A03061970 | alizapride | DRD2 | dopamine receptor antagonist | Details | |
| C00191 | BRD-K73191876 | alizarin | Details | |||
| C00192 | BRD-A96407378 | allantoin | cosmetic | Details | ||
| C00193 | BRD-A60402836 | allicin | TRPA1|TRPV1 | cytokine production inhibitor | Details | |
| C00194 | BRD-A03204438 | allopregnanolone | GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB2|GABRG2 | GABA receptor positive allosteric modulator | Details | |
| C00195 | BRD-K86307448 | allopurinol | XDH | xanthine oxidase inhibitor | Details | |
| C00196 | BRD-A93407926 | allopurinol-riboside | anti-leishmanial agent | Details | ||
| C00197 | BRD-K12872829 | allylestrenol | ESR1|PGR|SLC6A9 | steroidal progestin | Details | |
| C00198 | BRD-K33219225 | allylisothiocyanate | TRPA1 | TRPV agonist | Details | |
| C00199 | BRD-K89634775 | allylthiourea | nitrification inhibitor | Details | ||
| C00200 | BRD-K82677201 | almitrine | ATP1A1 | neurotransmitter agonist | Details |