CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

CMap Candidates

CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.

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6125 records.

CMap ID	Pert ID	Compound Name	Targets	MoA
C01701	BRD-K10974103	diloxanide		protein synthesis inhibitor	Details
C01702	BRD-K24023109	diltiazem	CACNA1C\|CACNA1S\|CACNA2D1\|CACNG1\|HTR3A\|KCNA5	calcium channel blocker	Details
C01703	BRD-K23541596	dimaprit	HRH2\|HRH3\|HRH4	histamine receptor agonist	Details
C01704	BRD-K29812331	dimemorfan	SIGMAR1	sigma receptor agonist	Details
C01705	BRD-M98649031	dimenhydrinate	HRH1	histamine receptor antagonist	Details
C01706	BRD-A56152450	dimercaprol		chelating agent	Details
C01707	BRD-K88701661	dimercaptosuccinic-acid	DNMT1	chelating agent	Details
C01708	BRD-K30126819	dimesna		tubulin polymerization inhibitor	Details
C01709	BRD-K43687498	dimethadione		oxazolidine antiepileptic	Details
C01710	BRD-K26674746	dimethicone			Details
C01711	BRD-K83192048	dimethindene-(S)-(+)	HRH1	acetylcholine receptor antagonist	Details
C01712	BRD-K73391359	dimethisoquin		local anesthetic	Details
C01713	BRD-K31111078	dimethyl-fumarate	KEAP1	nuclear factor erythroid derived; like (NRF2) activator	Details
C01714	BRD-A17224697	dimethyl-isosorbide		cosmetic moisturizer	Details
C01715	BRD-A54141700	dimetindene	CHRM2\|HRH1	histamine receptor antagonist; cholinergic receptor antagonist	Details
C01716	BRD-K72728560	dimetridazole		bacterial DNA inhibitor	Details
C01717	BRD-K92848252	diminazene-aceturate	AOC1\|PRDX5\|PRSS1	angiotensin converting enzyme activator	Details
C01718	BRD-K60567437	dimpylate	ACHE	acetylcholinesterase inhibitor	Details
C01719	BRD-K13662825	dinaciclib	CDK1\|CDK2\|CDK5\|CDK9	CDK inhibitor	Details
C01720	BRD-K93240442	dinitolmide			Details
C01721	BRD-K81672972	dinoprost	PTGDR\|PTGDR2\|PTGER1\|PTGER2\|PTGER3\|PTGER4\|PTGFR\|PTGIR\|TBXA2R	prostacyclin analog	Details
C01722	BRD-K26521938	dinoprostone	CATSPER1\|CATSPER2\|CATSPER3\|CATSPER4\|PTGDR\|PTGDR2\|PTGER1\|PTGER2\|PTGER3\|PTGER4\|PTGFR\|TBXA2R	prostanoid receptor agonist	Details
C01723	BRD-K37723606	dioscin	CXCR3	apoptosis stimulant	Details
C01724	BRD-K28690501	diosgenin		steroid	Details
C01725	BRD-K26862302	diosmetin	CYP1B1	aryl hydrocarbon receptor agonist	Details
C01726	BRD-K94436377	diosmin	AHR	aryl hydrocarbon receptor agonist; capillary stabilizing agent	Details
C01727	BRD-K22193694	dioxybenzone		topical sunscreen agent	Details
C01728	BRD-K11595419	dipeptamin			Details
C01729	BRD-A30693873	diperodon		local anesthetic	Details
C01730	BRD-K93441486	diphemanil	CHRM3	acetylcholine receptor antagonist	Details
C01731	BRD-K51730347	diphencyprone		immunostimulant	Details
C01732	BRD-K47278471	diphenhydramine	HRH1	histamine receptor antagonist	Details
C01733	BRD-K01663662	diphenidol	CHRM1\|CHRM2\|CHRM3\|CHRM4	acetylcholine receptor agonist	Details
C01734	BRD-K65814004	diphenyleneiodonium	NOS2\|NOS3	nitric oxide synthase inhibitor	Details
C01735	BRD-K12362304	diphenylguanidine			Details
C01736	BRD-K22936972	diphenylpyraline	HRH1\|SLC6A3	dopamine uptake inhibitor	Details
C01737	BRD-A47494775	dipivefrine	ACHE\|ADRA1A\|ADRA2A\|ADRB2\|BCHE	adrenergic receptor agonist	Details
C01738	BRD-K64838454	dipraglurant	GRM5	glutamate receptor negative allosteric modulator	Details
C01739	BRD-K75385383	DIPT	HTR1A\|HTR2A\|HTR2C	dopamine reuptake inhibitor; serotonin reuptake inhibitor	Details
C01740	BRD-K86301799	dipyridamole	ADA\|PDE10A\|PDE1A\|PDE1B\|PDE1C\|PDE2A\|PDE3A\|PDE3B\|PDE4A\|PDE4B\|PDE4C\|PDE4D\|PDE5A\|PDE6A\|PDE6B\|PDE6C\|PDE6D\|PDE6G\|PDE6H\|PDE7A\|PDE7B\|PDE8A\|PDE8B\|PDE9A\|SLC29A1	phosphodiesterase inhibitor	Details
C01741	BRD-K47608922	dipyrocetyl		chelating agent	Details
C01742	BRD-K52756523	dirithromycin		bacterial 50S ribosomal subunit inhibitor	Details
C01743	BRD-K87386013	diroximel-fumarate		anti-inflammatory agent	Details
C01744	BRD-K66672047	disodium sebacate	HBA1\|HBB		Details
C01745	BRD-A29734509	disopyramide	CHRM1\|CHRM2\|CHRM3\|KCND2\|KCND3\|KCNH2\|SCN5A	sodium channel blocker	Details
C01746	BRD-K32744045	disulfiram	ALDH2\|DBH	aldehyde dehydrogenase inhibitor; DNA methyltransferase inhibitor; TRPV agonist	Details
C01747	BRD-K51807679	dithranol		DNA synthesis inhibitor	Details
C01748	BRD-K40654626	ditiocarb-sodium-trihydrate	CA1\|CA2\|CA4	immunostimulant	Details
C01749	BRD-K33459542	ditolylguanidine	GRIN1\|GRIN2A\|GRIN2B\|SIGMAR1	sigma receptor agonist	Details
C01750	BRD-K41260949	divalproex-sodium	ALDH5A1	benzodiazepine receptor agonist	Details
C01751	BRD-K05919151	dixanthogen			Details
C01752	BRD-K58930050	dizocilpine-(+)	GRIN1\|GRIN2A\|GRIN2B\|GRIN2C\|GRIN2D	glutamate receptor antagonist	Details
C01753	BRD-K23163214	dizocilpine-(-)		glutamate receptor antagonist	Details
C01754	BRD-K26573499	DMAB-anabaseine	CHRNA7	adrenergic receptor agonist	Details
C01755	BRD-K36775483	DMeOB	GRM5		Details
C01756	BRD-K39381259	DMH1	ACVR1	ALK tyrosine kinase receptor inhibitor	Details
C01757	BRD-K40575944	DMH4	KDR	VEGFR inhibitor	Details
C01758	BRD-K03564313	DMNB		DNA dependent protein kinase inhibitor	Details
C01759	BRD-K89274813	DMP-543		acetylcholine release enhancer	Details
C01760	BRD-K54936858	DMP-777	MPO	elastase inhibitor	Details
C01761	BRD-A22971209	DMPS		chelating agent	Details
C01762	BRD-M56212252	DMSO		control vehicle	Details
C01763	BRD-K64400208	DNQX	GRIA1\|GRIA2\|GRIK1\|GRIN1\|GRIN2A\|GRIN2B	glutamate receptor antagonist	Details
C01764	BRD-A78322124	dobutamine	ADRB1\|ADRB2	adrenergic receptor agonist	Details
C01765	BRD-K08290224	docebenone	ALOX5	lipoxygenase inhibitor	Details
C01766	BRD-K30577245	docetaxel	BCL2\|MAP2\|MAP4\|MAPT\|NR1I2\|TUBB\|TUBB1	tubulin polymerization inhibitor	Details
C01767	BRD-K39965020	doconexent	FFAR1\|PTGS1\|PTGS2	PPAR receptor agonist	Details
C01768	BRD-K61937613	doconexent-ethyl-ester		omega 3 fatty acid stimulant	Details
C01769	BRD-K50050533	docosanol	TLR7	lipase clearing factor inhibitor	Details
C01770	BRD-A00092689	docusate		laxative	Details
C01771	BRD-K05680146	dodecyl-sulfate	LYZ		Details
C01772	BRD-A14941520	dofequidar	ABCB1	MRP inhibitor; P glycoprotein inhibitor	Details
C01773	BRD-K86887724	dofetilide	KCNH1\|KCNH2\|KCNJ12\|KCNK2	potassium channel blocker	Details
C01774	BRD-K28029915	dolasetron	HTR3A	serotonin receptor antagonist	Details
C01775	BRD-K78567475	dolastatin-10	TUBB	tubulin polymerization inhibitor	Details
C01776	BRD-K36386086	dolutegravir	CYP3A4\|CYP3A5\|CYP3A7\|POU2F2\|UGT1A1	HIV integrase inhibitor	Details
C01777	BRD-K30431096	domiphen			Details
C01778	BRD-K38305202	domperidone	DRD2\|DRD3	dopamine receptor antagonist	Details
C01779	BRD-A49160188	donepezil	ACHE\|HTR2A	acetylcholinesterase inhibitor	Details
C01780	BRD-K31092604	donitriptan	HTR1A\|HTR1B\|HTR1D\|HTR1E\|HTR1F\|HTR2A\|HTR5A\|HTR6	serotonin receptor agonist	Details
C01781	BRD-K43887077	dopamine	DBH\|DRD1\|DRD2\|DRD3\|DRD4\|DRD5\|HTR1A\|HTR7\|SLC6A2\|SLC6A3\|SLC6A4	dopamine receptor agonist	Details
C01782	BRD-K74065929	doramapimod	MAPK11\|MAPK12\|MAPK13\|MAPK14	p38 MAPK inhibitor	Details
C01783	BRD-A16350940	doramectin			Details
C01784	BRD-K45319714	doripenem	DPEP1	bacterial cell wall synthesis inhibitor	Details
C01785	BRD-K54233340	dorsomorphin	ACVR1\|BMPR1A\|BMPR1B\|EPHA2\|FKBP1A\|FLT1\|FLT3\|KDR\|LCK\|MKNK1\|PRKAA1\|RPS6KA1\|SRC	AMPK inhibitor	Details
C01786	BRD-K71075609	dorzolamide	CA1\|CA12\|CA14\|CA2\|CA4\|CA7	carbonic anhydrase inhibitor	Details
C01787	BRD-K54759182	dosulepin	CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|HRH1\|SLC6A2\|SLC6A4	norepinephrine reuptake inhibitor; serotonin norepinephrine reuptake inhibitor (SNRI); tricyclic antidepressant	Details
C01788	BRD-K85402309	dovitinib	CSF1R\|EGFR\|FGFR1\|FGFR2\|FGFR3\|FLT1\|FLT3\|FLT4\|INSR\|KDR\|KIT\|PDGFRA\|PDGFRB	EGFR inhibitor; FGFR inhibitor; FLT3 inhibitor; PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor	Details
C01789	BRD-A46179541	doxapram	KCNK3\|KCNK9	potassium channel blocker	Details
C01790	BRD-A13188892	doxazosin	ADRA1A\|ADRA1B\|ADRA1D\|KCNH2\|KCNH6\|KCNH7	adrenergic receptor antagonist	Details
C01791	BRD-K37694030	doxepin	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD2\|HRH1\|HRH2\|HRH4\|HTR1A\|HTR2A\|HTR2B\|HTR2C\|HTR6\|KCNH2\|SLC6A2\|SLC6A4	histamine receptor antagonist	Details
C01792	BRD-K82928892	doxercalciferol	VDR	vitamin D receptor agonist	Details
C01793	BRD-K58262659	doxifluridine	TYMS	thymidylate synthase inhibitor	Details
C01794	BRD-K70507123	doxofylline	ADORA1\|PDE4A\|PDE4B\|PDE4C\|PDE4D	adenosine receptor antagonist	Details
C01795	BRD-K92093830	doxorubicin	TOP2A	topoisomerase inhibitor	Details
C01796	BRD-A08545410	doxycycline	MMP8	metalloproteinase inhibitor	Details
C01797	BRD-M28128163	doxycycline-hyclate		bacterial 30S ribosomal subunit inhibitor	Details
C01798	BRD-A44008656	doxylamine	CHRM1\|HRH1	histamine receptor antagonist	Details
C01799	BRD-K37087535	DPC-681		HIV protease inhibitor	Details
C01800	BRD-K01824921	DPCPX	ADORA1\|ADORA2A\|ADORA2B\|ADORA3	adenosine receptor antagonist	Details