CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C02401 | BRD-K52394958 | GR-159897 | TAC1|TACR2 | tachykinin antagonist | Details | |
| C02402 | BRD-K26674531 | GR-235 | NR1H4 | estrogen receptor agonist; FXR antagonist; progesterone receptor agonist | Details | |
| C02403 | BRD-K40578143 | GR-79236 | ADORA1|ADORA2A | adenosine receptor agonist | Details | |
| C02404 | BRD-A52977603 | gramicidin | bacterial permeability inducer | Details | ||
| C02405 | BRD-K26005076 | gramine | norepinephrine reputake inhibitor | Details | ||
| C02406 | BRD-A10967948 | granisetron | HTR3A | serotonin receptor antagonist | Details | |
| C02407 | BRD-K62050508 | grapiprant | PTGER4 | prostaglandin inhibitor | Details | |
| C02408 | BRD-K24943235 | grazoprevir | HCV inhibitor | Details | ||
| C02409 | BRD-K08273968 | griseofulvin | KRT12 | tubulin polymerization inhibitor | Details | |
| C02410 | BRD-K62594868 | GR125487 | HTR4 | serotonin receptor antagonist | Details | |
| C02411 | BRD-K98155362 | GR46611 | HTR1D | serotonin receptor agonist | Details | |
| C02412 | BRD-K99916169 | GS-143 | BTRC|NFKBIA | ubiquitin ligase inhibitor | Details | |
| C02413 | BRD-K75478907 | GS-39783 | GABBR1 | GABA receptor modulator | Details | |
| C02414 | BRD-K68453341 | GS-6201 | ADORA1|ADORA2A|ADORA2B|ADORA3 | adenosine receptor antagonist | Details | |
| C02415 | BRD-K73585091 | GS-9620 | TLR7 | toll-like receptor agonist | Details | |
| C02416 | BRD-K76719364 | GS-9973 | SYK | syk inhibitor | Details | |
| C02417 | BRD-K32847255 | GSK-J1 | KDM6B | histone demethylase inhibitor | Details | |
| C02418 | BRD-K82484347 | GSK-J2 | histone demethylase inhibitor | Details | ||
| C02419 | BRD-K98203492 | GSK-J4 | KDM6A|KDM6B | histone lysine demethylase inhibitor | Details | |
| C02420 | BRD-K55438324 | GSK-J5 | histone demethylase control | Details | ||
| C02421 | BRD-K33521504 | GSK-LSD-1 | KDM1A | histone lysine demethylase inhibitor | Details | |
| C02422 | BRD-K98684188 | GSK-0660 | PPARD | PPAR receptor antagonist | Details | |
| C02423 | BRD-K36697397 | GSK-1562590 | UTS2R | urotensin receptor antagonist | Details | |
| C02424 | BRD-K90737788 | GSK-2193874 | TRPV4 | transient receptor potential channel antagonist | Details | |
| C02425 | BRD-K50679358 | GSK-2837808A | LDHA | lactate dehydrogenase inhibitor | Details | |
| C02426 | BRD-K04923131 | GSK-3-inhibitor-IX | GSK3A|GSK3B | glycogen synthase kinase inhibitor; lipoxygenase inhibitor | Details | |
| C02427 | BRD-K26514105 | GSK-37647 | FFAR4 | free fatty acid receptor agonist | Details | |
| C02428 | BRD-K06750613 | GSK1059615 | PIK3CG | PI3K inhibitor | Details | |
| C02429 | BRD-K36740062 | GSK1070916 | AURKA|AURKB|AURKC|CYP2D6|CYP3A4 | Aurora kinase inhibitor | Details | |
| C02430 | BRD-K60341624 | GSK1292263 | GRPR | glucose dependent insulinotropic receptor agonist | Details | |
| C02431 | BRD-K69669039 | GSK163090 | HTR1A|HTR1B|HTR1D | serotonin receptor antagonist | Details | |
| C02432 | BRD-K06749501 | GSK1838705A | ALK|IGF1R|INSR|RPS6KA1 | insulin growth factor receptor inhibitor | Details | |
| C02433 | BRD-K04833372 | GSK1904529A | IGF1R|INSR | IGF-1 inhibitor; insulin growth factor receptor inhibitor; insulin receptor ligand | Details | |
| C02434 | BRD-K25412176 | GSK2110183 | AKT1|AKT2|AKT3 | AKT inhibitor | Details | |
| C02435 | BRD-K07972848 | GSK2126458 | MTOR|PIK3CA|PIK3CB|PIK3CD|PIK3CG | mTOR inhibitor; PI3K inhibitor | Details | |
| C02436 | BRD-K15691453 | GSK2190915 | ALOX5AP | lipoxygenase inhibitor | Details | |
| C02437 | BRD-K95123482 | GSK2194069 | FASN | fatty acid synthase inhibitor | Details | |
| C02438 | BRD-K62738477 | GSK2256294A | EPHX2 | epoxide hydolase inhibitor | Details | |
| C02439 | BRD-K05858796 | GSK2330672 | SLC10A2 | bile acid transporter inhibitor | Details | |
| C02440 | BRD-K70642949 | GSK2334470 | AURKA|AURKB|PDPK1 | phosphoinositide dependent kinase inhibitor | Details | |
| C02441 | BRD-K37590257 | GSK256066 | PDE4A | phosphodiesterase inhibitor | Details | |
| C02442 | BRD-K30185465 | GSK2578215A | LRRK2 | leucine rich repeat kinase inhibitor | Details | |
| C02443 | BRD-K81689258 | GSK2606414 | EIF2AK3|MYLK2 | protein kinase inhibitor | Details | |
| C02444 | BRD-K49215523 | GSK2636771 | PIK3CB | PI3K inhibitor | Details | |
| C02445 | BRD-K41104902 | GSK2656157 | PERK inhibitor | Details | ||
| C02446 | BRD-K89464729 | GSK269962 | ROCK1|ROCK2 | rho associated kinase inhibitor | Details | |
| C02447 | BRD-K48062199 | GSK2801 | BAZ2A|BAZ2B | bromodomain inhibitor | Details | |
| C02448 | BRD-K21867462 | GSK2816126 | EZH2 | histone lysine methyltransferase inhibitor | Details | |
| C02449 | BRD-K17472821 | GSK2830371 | PPM1D | protein phosphatase inhibitor | Details | |
| C02450 | BRD-K08398903 | GSK2838232 | HIV gag inhibitor | Details | ||
| C02451 | BRD-K09223495 | GSK2879552 | KDM1A | histone lysine demethylase inhibitor | Details | |
| C02452 | BRD-K03155172 | GSK3787 | PPARD | PPAR receptor antagonist | Details | |
| C02453 | BRD-A10523515 | GSK429286A | ROCK1 | rho associated kinase inhibitor | Details | |
| C02454 | BRD-K92428232 | GSK461364 | PLK1 | PLK inhibitor | Details | |
| C02455 | BRD-K72293620 | GSK503 | EZH2 | histone lysine methyltransferase inhibitor | Details | |
| C02456 | BRD-K14991967 | GSK650394 | SGK1|SGK2 | serum/glucocorticoid regulated kinase inhibitor | Details | |
| C02457 | BRD-K25325018 | GSK690693 | AKT1|AKT2|AKT3|PAK4|PAK6|PAK7|PRKCQ|PRKG1|PRKX | AKT inhibitor | Details | |
| C02458 | BRD-K29328421 | GSK9027 | NR3C1 | glucocorticoid receptor agonist | Details | |
| C02459 | BRD-K89015388 | GSK923295 | CENPE | centromere associated protein inhibitor | Details | |
| C02460 | BRD-K16664969 | GTP-14564 | CSF1R|FLT3|KIT|PDGFRB | FLT3 inhibitor; tyrosine kinase inhibitor | Details | |
| C02461 | BRD-K14235254 | GTS21 | CHRNA7 | cholinergic receptor agonist | Details | |
| C02462 | BRD-K00739965 | guacetisal | immunosuppressant | Details | ||
| C02463 | BRD-K96282009 | guaiacol | CA2 | local anesthetic | Details | |
| C02464 | BRD-A90515964 | guaifenesin | expectorant | Details | ||
| C02465 | BRD-K62736196 | guanaben-acetate | ADRA2A|ADRA2B|ADRA2C | adrenergic receptor agonist | Details | |
| C02466 | BRD-A14262390 | guanadrel | SLC6A2 | adrenergic inhibitor | Details | |
| C02467 | BRD-K62676709 | guanethidine | SLC6A2 | adrenergic inhibitor | Details | |
| C02468 | BRD-K32830106 | guanfacine | ADRA2A|ADRA2B|ADRA2C | adrenergic receptor agonist | Details | |
| C02469 | BRD-K76037122 | guanidine | ALDH2|DLG4|GAMT|RNASE1 | HSP inhibitor | Details | |
| C02470 | BRD-K69191882 | guanidinoethyldisulfide-bicarbonate | NOS2 | nitric oxide synthase inhibitor | Details | |
| C02471 | BRD-K50781608 | guanidinopropionic-acid | CKM | creatine kinase inhibitor | Details | |
| C02472 | BRD-K92976206 | guanosine | PNP | Details | ||
| C02473 | BRD-K18745919 | Gue-1654 | OXER1 | oxoeicosanoid receptor modulator | Details | |
| C02474 | BRD-K01980392 | guvacine | SLC6A1|SLC6A11|SLC6A12|SLC6A13 | GABA uptake inhibitor | Details | |
| C02475 | BRD-K82983861 | GW-0742 | PPARD | PPAR receptor agonist | Details | |
| C02476 | BRD-K23614267 | GW-1100 | FFAR1 | G protein-coupled receptor agonist | Details | |
| C02477 | BRD-A15415227 | GW-1929 | PPARG | PPAR receptor agonist | Details | |
| C02478 | BRD-K24242599 | GW-2580 | CSF1R | cFMS kinase inhibitor | Details | |
| C02479 | BRD-K37864785 | GW-311616 | ELANE | leukocyte elastase inhibitor; elastase inhibitor | Details | |
| C02480 | BRD-K33818169 | GW-3965 | NR1H2|NR1H3 | LXR agonist | Details | |
| C02481 | BRD-K10705233 | GW-405833 | CNR2 | cannabinoid receptor agonist | Details | |
| C02482 | BRD-K88186167 | GW-4064 | NR1H4 | FXR agonist | Details | |
| C02483 | BRD-K13039700 | GW-438014A | NPY5R | neuropeptide receptor antagonist | Details | |
| C02484 | BRD-K41312087 | GW-441756 | NTRK1 | growth factor receptor inhibitor | Details | |
| C02485 | BRD-K14880289 | GW-501516 | PPARA|PPARD | PPAR receptor agonist | Details | |
| C02486 | BRD-K39520573 | GW-5074 | NTRK1|RAF1 | RAF inhibitor; leucine rich repeat kinase inhibitor | Details | |
| C02487 | BRD-K36485341 | GW-542573X | KCNN1 | calcium channel activator | Details | |
| C02488 | BRD-K79930101 | GW-583340 | EGFR|ERBB2 | EGFR inhibitor | Details | |
| C02489 | BRD-K50005760 | GW-627368 | PTGER4 | prostanoid receptor antagonist | Details | |
| C02490 | BRD-K20828910 | GW-6471 | PPARA | PPAR receptor antagonist | Details | |
| C02491 | BRD-K96263742 | GW-7647 | PPARA | PPAR receptor agonist | Details | |
| C02492 | BRD-K78086729 | GW-788388 | LCK|MAPK14|TGFBR1 | ALK tyrosine kinase receptor inhibitor | Details | |
| C02493 | BRD-K65576800 | GW-803430 | KCNH2|MCHR1 | melanin inhibitor | Details | |
| C02494 | BRD-K26823213 | GW-842166 | CNR2 | cannabinoid receptor agonist | Details | |
| C02495 | BRD-K90382497 | GW-843682X | PLK1|PLK3 | PLK inhibitor | Details | |
| C02496 | BRD-K71534238 | GW-9508 | FFAR1|FFAR4 | free fatty acid receptor agonist; G protein-coupled receptor agonist | Details | |
| C02497 | BRD-K93258693 | GW-9662 | NCOA2|PPARG|RXRA | PPAR receptor antagonist | Details | |
| C02498 | BRD-K24240364 | GYKI-52466 | GRIA1|GRIA2|GRIA3|GRIA4 | glutamate receptor antagonist | Details | |
| C02499 | BRD-K58775955 | gynostemma-extract | calcium channel modulator | Details | ||
| C02500 | BRD-K35329391 | GZD824 | ABL1|BCR | Bcr-Abl kinase inhibitor | Details |