CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

CMap Candidates

CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.

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Associated NAFLD Targets:

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6125 records.

CMap ID	Pert ID	Compound Name	Targets	MoA
C03201	BRD-A93683007	mabuprofen		cyclooxygenase inhibitor	Details
C03202	BRD-A13116749	mabuterol	ADRB2	adrenergic receptor agonist	Details
C03203	BRD-K94948151	macelignan		antioxidant; antiinflammatory agent	Details
C03204	BRD-K48812570	macitentan	EDNRA\|EDNRB	endothelin receptor antagonist	Details
C03205	BRD-K48905682	madrasin		cell splicing inhibitor	Details
C03206	BRD-K30649484	mafenide	CA12\|CA14\|CA2\|CA4\|CA6\|CA9	carbonic anhydrase inhibitor	Details
C03207	BRD-K26168087	magnolol	GABRA1\|PPARG	PPAR receptor agonist	Details
C03208	BRD-A01976766	malathion	ACHE\|BCHE	cholinesterase inhibitor	Details
C03209	BRD-A18396475	malic-acid	CS\|ME2\|PKD2L1		Details
C03210	BRD-K97884852	malotilate		protein synthesis stimulant	Details
C03211	BRD-K01624185	maltobionic-acid		matrix metalloprotease inhibitor	Details
C03212	BRD-A91448670	mandelic-acid			Details
C03213	BRD-K57365211	mangafodipir		contrast agent	Details
C03214	BRD-A90695733	manidipine	CACNA1C\|CACNA1D	calcium channel blocker	Details
C03215	BRD-K66035042	mannitol-D		diuretic	Details
C03216	BRD-K25433859	maprotiline	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD2\|HRH1\|HTR2A\|HTR2C\|HTR7\|SLC6A2	norepinephrine reputake inhibitor; tricyclic antidepressant	Details
C03217	BRD-A04352665	maraviroc	CCR5	CC chemokine receptor antagonist	Details
C03218	BRD-K71926323	marbofloxacin		bacterial DNA gyrase inhibitor	Details
C03219	BRD-K59524082	maribavir	PYGM	cytomegalovirus inhibitor; protein kinase inhibitor	Details
C03220	BRD-K21396683	marimastat	MMP1\|MMP10\|MMP11\|MMP12\|MMP13\|MMP14\|MMP15\|MMP16\|MMP17\|MMP19\|MMP2\|MMP20\|MMP21\|MMP23A\|MMP24\|MMP25\|MMP26\|MMP27\|MMP28\|MMP3\|MMP7\|MMP8\|MMP9	matrix metalloprotease inhibitor	Details
C03221	BRD-K76594255	maropitant	TACR1	neurokinin receptor antagonist	Details
C03222	BRD-K71035033	masitinib	FGFR3\|KIT\|PDGFRA\|PDGFRB	KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor; src inhibitor	Details
C03223	BRD-A87130939	masoprocol	ALOX5	lipoxygenase inhibitor	Details
C03224	BRD-K25312248	matrine	OPRK1	opioid receptor agonist	Details
C03225	BRD-K07790550	mavoglurant	GRM5	glutamate receptor antagonist	Details
C03226	BRD-K81332461	maxacalcitol	VDR	vitamin D receptor agonist	Details
C03227	BRD-K15898725	maytansinol-isobutyrate			Details
C03228	BRD-A68464583	mazindol	SLC6A2\|SLC6A3\|SLC6A4	dopamine reuptake inhibitor; selective serotonin reuptake inhibitor (SSRI)	Details
C03229	BRD-K32218650	MBX-2982	GPR119	glucose dependent insulinotropic receptor agonist	Details
C03230	BRD-K50712474	MC-1	AADAT\|ABAT\|AGXT\|AGXT2\|ALAS1\|AZIN2\|BCAT1\|BCAT2\|CBS\|CCBL1\|CCBL2\|CSAD\|CTH\|DDC\|FTCD\|GAD1\|GAD2\|GADL1\|GCAT\|GLDC\|GOT1\|GOT2\|GPT\|GPT2\|HDC\|IGSF10\|KYNU\|MOCOS\|NFS1\|OAT\|ODC1\|PDXDC1\|PDXP\|PHYKPL\|PNPO\|PROSC\|PSAT1\|PYGB\|PYGL\|PYGM\|SCLY\|SDS\|SDSL\|SEPSECS\|SGPL1\|SHMT1\|SHMT2\|SPTLC1\|SPTLC2\|SPTLC3\|SRR\|TAT\|THNSL1		Details
C03231	BRD-K55418700	MCC950	NLRP3	NOD like receptor inhibitor	Details
C03232	BRD-K31168993	McN-5652-(+/-)		selective serotonin reuptake inhibitor (SSRI)	Details
C03233	BRD-K73276278	MCOPPB	OPRL1	nociceptin/orphanin FQ (NOP) receptor agonist	Details
C03234	BRD-K75844781	mCPP	HTR1A\|HTR1D\|HTR1E\|HTR2A\|HTR2B\|HTR2C\|HTR6	serotonin receptor agonist	Details
C03235	BRD-K24031866	MC1568	HDAC2	HDAC inhibitor	Details
C03236	BRD-K92758126	MD-920	AADACL2	NFkB pathway inhibitor	Details
C03237	BRD-K61128465	mdivi-1	DNM1	dynamin inhibitor	Details
C03238	BRD-A62057054	MDL-11939	HTR2A\|HTR2B\|HTR2C	serotonin receptor antagonist	Details
C03239	BRD-K50888640	MDL-27531		glycine receptor agonist	Details
C03240	BRD-K59753853	MDL-29951	FBP1	glutamate receptor antagonist	Details
C03241	BRD-A17453586	MDL-72832	HTR1A	serotonin receptor agonist	Details
C03242	BRD-A50764878	MDL-73005EF	HTR1A	serotonin receptor antagonist	Details
C03243	BRD-K70840370	MDMS		DNA inhibitor	Details
C03244	BRD-K24283677	ME-0328	PARP3	PPAR receptor antagonist	Details
C03245	BRD-K77987382	mebendazole	TUBA1A\|TUBB\|TUBB4B	tubulin polymerization inhibitor	Details
C03246	BRD-A09467419	mebeverine	CHRM1	acetylcholine receptor antagonist	Details
C03247	BRD-K29713308	mebhydrolin		antihistamine	Details
C03248	BRD-K29713308	mebhydroline-1,5-naphtalenedisulfonate			Details
C03249	BRD-K76606751	mebicar		anxiolytic	Details
C03250	BRD-K96691275	mebrofenin			Details
C03251	BRD-A20119038	mecamylamine	CHRNA1\|CHRNA2\|CHRNA3\|CHRNA4\|CHRNA6\|CHRNA7	acetylcholine receptor antagonist	Details
C03252	BRD-K28405228	mecarbinate			Details
C03253	BRD-K12829205	mechlorethamine		DNA inhibitor	Details
C03254	BRD-K25075681	meclinertant	NTSR1\|NTSR2	neurotensin receptor antagonist	Details
C03255	BRD-A50311610	meclizine	HRH1\|NR1I3	constitutive androstane receptor (CAR) agonist	Details
C03256	BRD-A07600638	meclocycline-sulfosalicylate		bacterial 50S ribosomal subunit inhibitor	Details
C03257	BRD-K50398167	meclofenamic-acid	ALOX5\|CNR1\|KCNQ2\|KCNQ3\|PTGS1\|PTGS2	cyclooxygenase inhibitor; prostanoid receptor antagonist	Details
C03258	BRD-K10314788	meclofenoxate		nootropic agent	Details
C03259	BRD-A77473570	mecysteine		analgesic agent	Details
C03260	BRD-A21607826	medetomidine	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C	adrenergic receptor agonist	Details
C03261	BRD-K92908289	medica-16	FFAR1	ATP citrase lyase inhibitor	Details
C03262	BRD-K40715924	medorinone			Details
C03263	BRD-K94072573	medronic-acid		bone resorption inhibitor	Details
C03264	BRD-K99615199	medroxyprogesterone	ESR1\|PGR	progesterone receptor agonist	Details
C03265	BRD-A61221616	medroxyprogesterone-acetate		progesterone receptor agonist	Details
C03266	BRD-A59014912	medrysone	NR3C1	glucocorticoid receptor agonist	Details
C03267	BRD-K92778217	mefenamic-acid	KCNQ1\|PTGS1\|PTGS2\|TRPM3	cyclooxygenase inhibitor	Details
C03268	BRD-K20655524	mefexamide		psychoactive drug	Details
C03269	BRD-A89585551	mefloquine	ADORA2A\|HBA1	adenosine receptor antagonist; hemoglobin antagonist	Details
C03270	BRD-K19507340	megestrol-acetate	NR3C1\|PGR	progesterone receptor agonist	Details
C03271	BRD-K51324732	meglitinide	CCR2	potassium channel blocker	Details
C03272	BRD-K28595280	meglumine		excipient	Details
C03273	BRD-K00495673	meglutol	HMGCR	HMGCR inhibitor	Details
C03274	BRD-K14529030	meisoindigo	STAT3	STAT inhibitor	Details
C03275	BRD-K12244279	MEK1-2-inhibitor	MAP2K2	MEK inhibitor	Details
C03276	BRD-K82244583	MEK162	MAP2K1\|MAP2K2	MEK inhibitor	Details
C03277	BRD-K97530723	melatonin	ASMT\|CALM1\|CALR\|EPX\|ESR1\|HTR2B\|MPO\|MTNR1A\|MTNR1B\|NQO2\|RORB	melatonin receptor agonist; nitric oxide synthase inhibitor	Details
C03278	BRD-K79392608	meldonium	BBOX1	gamma butyrobetaine hydroxylase inhibitor	Details
C03279	BRD-A42746051	melengestrol-acetate		progesterone receptor agonist	Details
C03280	BRD-A25827085	melevodopa	DDC	dopamine precursor; dopamine receptor agonist	Details
C03281	BRD-A84174393	meloxicam	PTGS1\|PTGS2	cyclooxygenase inhibitor	Details
C03282	BRD-K92984783	melperone	DRD2\|HTR2A	dopamine receptor antagonist; serotonin receptor antagonist	Details
C03283	BRD-K87827419	melphalan		DNA alkylating agent; DNA inhibitor	Details
C03284	BRD-K36394566	melphalan-n-oxide	HIF1A	hypoxia inducible factor inhibitor	Details
C03285	BRD-A07164067	meluadrine			Details
C03286	BRD-A79803969	memantine	CHRFAM7A\|DRD2\|GRIN1\|GRIN2A\|GRIN2B\|GRIN3A\|HTR3A	glutamate receptor antagonist	Details
C03287	BRD-K78126613	menadione	AOX1\|BGLAP\|F10\|F2\|F7\|F9\|GGCX\|NQO1\|NQO2\|PROC\|PROS1\|PROZ\|VKORC1\|VKORC1L1	mitochondrial DNA polymerase inhibitor; phosphatase inhibitor	Details
C03288	BRD-A19777893	menadione-bisulfite	GGCX\|VKORC1\|VKORC1L1	vitamin K	Details
C03289	BRD-K75864342	menatetrenone		bone resorption inhibitor	Details
C03290	BRD-K53852914	menbutone			Details
C03291	BRD-A45889380	mepacrine	PLA2G1B\|PLA2G4A\|PLA2G6\|PLCL1	cytokine production inhibitor; NFkB pathway inhibitor; TP53 activator	Details
C03292	BRD-A11662333	meparfylon			Details
C03293	BRD-A82772293	mepazine	MALT1	MALT1 inhibitor (JH)	Details
C03294	BRD-A62421304	mepenzolate	CHRM1\|CHRM3	acetylcholine receptor antagonist	Details
C03295	BRD-A55469827	mephenesin		muscle relaxant	Details
C03296	BRD-K18194590	mephentermine	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C\|ADRB1\|ADRB2\|ADRB3	adrenergic receptor agonist	Details
C03297	BRD-A83937277	mephenytoin	SCN10A\|SCN11A\|SCN1A\|SCN2A\|SCN3A\|SCN4A\|SCN5A\|SCN7A\|SCN8A\|SCN9A	hydantoin antiepileptic	Details
C03298	BRD-K78299798	mepiroxol			Details
C03299	BRD-A03216249	mepivacaine	SCN10A	potassium channel blocker; sodium channel blocker	Details
C03300	BRD-K18207669	meprednisone	NR3C1		Details