CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C04001 | BRD-K83631119 | paeoniflorin | anticonvulsant | Details | ||
| C04002 | BRD-K94239562 | paeonol | anti-inflammatory agent | Details | ||
| C04003 | BRD-K68805147 | pafuramidine | DNA synthesis inhibitor | Details | ||
| C04004 | BRD-K51313569 | palbociclib | CDK4|CDK6 | CDK inhibitor | Details | |
| C04005 | BRD-K12047401 | palifosfamide | DNA alkylating agent | Details | ||
| C04006 | BRD-A99888680 | paliperidone | ADRA1A|ADRA1B|ADRA2A|ADRA2B|ADRA2C|CYP2D6|CYP3A4|CYP3A5|DRD1|DRD2|DRD3|DRD4|HRH1|HTR1A|HTR1D|HTR2A|HTR2C | dopamine receptor antagonist; serotonin receptor antagonist | Details | |
| C04007 | BRD-K58466253 | palmatine-chloride | CYP3A4 | dopamine synthesis inhibitor | Details | |
| C04008 | BRD-K91356052 | palmitoleic-acid | Details | |||
| C04009 | BRD-A77577770 | palmitoylcarnitine | protein kinase inhibitor | Details | ||
| C04010 | BRD-K68095457 | palmitoylethanolamide | CNR2|GPR119|GPR55 | cannabinoid receptor agonist | Details | |
| C04011 | BRD-A50998626 | palomid-529 | MTOR | AKT inhibitor; mTOR inhibitor | Details | |
| C04012 | BRD-K08924299 | palonosetron | HTR3A | serotonin receptor antagonist | Details | |
| C04013 | BRD-K07682953 | palosuran | UTS2R | urotensin receptor antagonist | Details | |
| C04014 | BRD-K83794243 | palovarotene | RARG | retinoid receptor agonist | Details | |
| C04015 | BRD-M67659203 | pamabrom | diuretic | Details | ||
| C04016 | BRD-K58513245 | pamidronate | FDPS | bone resorption inhibitor | Details | |
| C04017 | BRD-K50817623 | pancuronium | CHRM2|CHRM3|CHRNA1|CHRNA2 | acetylcholine receptor antagonist | Details | |
| C04018 | BRD-K02130563 | panobinostat | HDAC1|HDAC2|HDAC3|HDAC4|HDAC6|HDAC7|HDAC8|HDAC9 | HDAC inhibitor | Details | |
| C04019 | BRD-K68764924 | pantethine | coenzyme A precursor | Details | ||
| C04020 | BRD-A22380646 | pantoprazole | ATP4A | ATPase inhibitor | Details | |
| C04021 | BRD-K29392254 | pantothenic-acid | coenzyme A precursor | Details | ||
| C04022 | BRD-K18573821 | PAOPA | DRD2 | dopamine receptor modulator | Details | |
| C04023 | BRD-K15567136 | papaverine | PDE10A|PDE4B|PDE5A | phosphodiesterase inhibitor | Details | |
| C04024 | BRD-K62412084 | para-toluenesulfonamide | CA12|CA2|CA6|CA9 | Details | ||
| C04025 | BRD-K41524689 | paracetamol | FAAH|PTGS1|PTGS2|TRPV1 | cyclooxygenase inhibitor | Details | |
| C04026 | BRD-K40992116 | parachlorophenol | antiinfective drug | Details | ||
| C04027 | BRD-A22128695 | paramethadione | CACNA1G|CACNA1H|CACNA1I | anticonvulsant | Details | |
| C04028 | BRD-K24084088 | paraxanthine | adenosine receptor antagonist | Details | ||
| C04029 | BRD-K02407574 | parbendazole | TUBB | tubulin polymerization inhibitor | Details | |
| C04030 | BRD-K11851476 | pardoprunox | DRD2|DRD3|DRD4|HTR1A|HTR7 | serotonin receptor agonist; dopamine receptor agonist | Details | |
| C04031 | BRD-K13800121 | parecoxib | LTF | cyclooxygenase inhibitor | Details | |
| C04032 | BRD-K54799382 | parethoxycaine | local anesthetic | Details | ||
| C04033 | BRD-K83597974 | pargyline | MAOA|MAOB | monoamine oxidase inhibitor | Details | |
| C04034 | BRD-K60585088 | paricalcitol | VDR | vitamin D receptor agonist | Details | |
| C04035 | BRD-K89920762 | paritaprevir | HCV inhibitor | Details | ||
| C04036 | BRD-K36524108 | paromomycin | bacterial 30S ribosomal subunit inhibitor | Details | ||
| C04037 | BRD-K37991163 | paroxetine | CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|HTR2A|SLC6A2|SLC6A4 | selective serotonin reuptake inhibitor (SSRI) | Details | |
| C04038 | BRD-K07441213 | paroxypropione | gonadotropin inhibitor | Details | ||
| C04039 | BRD-K98548675 | parthenolide | NFkB pathway inhibitor | Details | ||
| C04040 | BRD-K34851558 | parthenolide-(-) | HDAC1 | NFkB pathway inhibitor | Details | |
| C04041 | BRD-K28120222 | parthenolide-(alternate-stereo) | IKBKB|RELA | NFkB pathway inhibitor | Details | |
| C04042 | BRD-K87202646 | pasiniazid | cyclooxygenase inhibitor | Details | ||
| C04043 | BRD-K59715032 | pasireotide | SSTR1|SSTR2|SSTR3|SSTR5 | somatostatin receptor agonist | Details | |
| C04044 | BRD-K74514084 | pazopanib | CSF1R|FGF1|FGFR1|FGFR3|FLT1|FLT4|ITK|KDR|KIT|PDGFRA|PDGFRB|SH2B3 | KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor | Details | |
| C04045 | BRD-K66412701 | pazufloxacin | topoisomerase inhibitor | Details | ||
| C04046 | BRD-A29289453 | PCA-4248 | PTAFR | platelet activating factor receptor antagonist | Details | |
| C04047 | BRD-K12867552 | PCI-24781 | HDAC1|HDAC2|HDAC3|HDAC6 | HDAC inhibitor | Details | |
| C04048 | BRD-K71223042 | PCI-29732 | BTK | Bruton's tyrosine kinase (BTK) inhibitor | Details | |
| C04049 | BRD-K88742110 | PCI-34051 | HDAC1|HDAC10|HDAC6|HDAC8 | HDAC inhibitor | Details | |
| C04050 | BRD-K52721684 | PCO-400 | KCNJ8 | potassium channel activator | Details | |
| C04051 | BRD-K49865102 | PD-0325901 | MAP2K1 | MEK inhibitor | Details | |
| C04052 | BRD-A89337244 | PD-102807 | CHRM4 | acetylcholine receptor antagonist | Details | |
| C04053 | BRD-K34657753 | PD-118057 | KCNH2 | potassium channel activator | Details | |
| C04054 | BRD-K34713073 | PD-123319 | AGTR2 | angiotensin antagonist | Details | |
| C04055 | BRD-K20260086 | PD-128907 | DRD2|DRD3 | dopamine receptor agonist | Details | |
| C04056 | BRD-K26603252 | PD-153035 | EGFR|KDR | EGFR inhibitor | Details | |
| C04057 | BRD-K13826399 | PD-156707 | EDNRA|EDNRB | endothelin receptor antagonist | Details | |
| C04058 | BRD-K48735772 | PD-158780 | EGFR | EGFR inhibitor | Details | |
| C04059 | BRD-K12079898 | PD-160170 | NPY1R | neuropeptide receptor antagonist | Details | |
| C04060 | BRD-K97152684 | PD-161570 | FGFR1 | FGFR inhibitor | Details | |
| C04061 | BRD-K93217218 | PD-166285 | EGFR|FGFR1|PDGFRB|PKMYT1|SRC|WEE1 | src inhibitor | Details | |
| C04062 | BRD-K60984070 | PD-166793 | MMP13|MMP2|MMP3 | collagenase inhibitor; metalloproteinase inhibitor | Details | |
| C04063 | BRD-K47761761 | PD-168077 | DRD2 | dopamine receptor agonist | Details | |
| C04064 | BRD-K17702546 | PD-168393 | EGFR|ERBB2|SRC | EGFR inhibitor | Details | |
| C04065 | BRD-A82013137 | PD-168568 | DRD2|DRD4 | dopamine receptor antagonist | Details | |
| C04066 | BRD-K97764662 | PD-173074 | FGFR1|FGFR2|FGFR3|FGFR4|FLT1|FLT4|KDR|PDGFRA|PDGFRB | FGFR inhibitor; VEGFR inhibitor | Details | |
| C04067 | BRD-K04426574 | PD-173212 | CACNA1B | calcium channel blocker | Details | |
| C04068 | BRD-K05104363 | PD-184352 | MAP2K1|MAP3K1|MAP3K2 | MEK inhibitor | Details | |
| C04069 | BRD-K88677950 | PD-198306 | MAP2K1|MAP2K2 | MAP kinase inhibitor; MEK inhibitor | Details | |
| C04070 | BRD-A57798112 | PD-318088 | MAP2K1 | MEK inhibitor | Details | |
| C04071 | BRD-K82823804 | PD-407824 | WEE1 | PKC inhibitor | Details | |
| C04072 | BRD-K77951111 | PD-81723 | ADORA1 | adenosine receptor agonist | Details | |
| C04073 | BRD-K62810658 | PD-98059 | AKT1|CHEK1|GSK3B|LCK|MAP2K1|MAPK1|MAPK11|MAPK12|MAPK14|MAPK8|PRKCA|RAF1|ROCK1|RPS6KB1|SGK1 | MEK inhibitor | Details | |
| C04074 | BRD-K38145871 | PDE10-IN-1 | PDE10A | phosphodiesterase inhibitor | Details | |
| C04075 | BRD-K26358347 | PDP-EA | FAAH | FAAH activator | Details | |
| C04076 | BRD-K04032780 | PD1-PDL-inhibitor-1 | CD274 | programmed death ligand inhibitor | Details | |
| C04077 | BRD-K21225231 | peficitinib | JAK1|JAK2|JAK3 | JAK inhibitor | Details | |
| C04078 | BRD-K55034111 | pefloxacin | TOP2A | bacterial DNA gyrase inhibitor | Details | |
| C04079 | BRD-K96436774 | pelanserin | HTR2A | serotonin receptor antagonist | Details | |
| C04080 | BRD-K08799216 | pelitinib | EGFR | EGFR inhibitor | Details | |
| C04081 | BRD-K32842773 | pemetrexed | ATIC|DHFR|GART|TYMS | dihydrofolate reductase inhibitor; thymidylate synthase inhibitor | Details | |
| C04082 | BRD-K31731454 | pemirolast | HRH1 | mediator release inhibitor | Details | |
| C04083 | BRD-K71075093 | pempidine | ganglionic blocker | Details | ||
| C04084 | BRD-K55705469 | penbutolol | ADRB1|ADRB2|HTR1A|HTR1B | adrenergic receptor antagonist | Details | |
| C04085 | BRD-K47780086 | penciclovir | DNA directed DNA polymerase inhibitor | Details | ||
| C04086 | BRD-K15409150 | penfluridol | CACNA1G | T-type calcium channel blocker | Details | |
| C04087 | BRD-K17518951 | penicillamine-(D) | chelating agent | Details | ||
| C04088 | BRD-A16376407 | penicillamine-(racemic) | Details | |||
| C04089 | BRD-K43966364 | penicillin-v-potassium | bacterial cell wall synthesis inhibitor | Details | ||
| C04090 | BRD-K48996094 | pentacosanoic-acid | Details | |||
| C04091 | BRD-K78789465 | pentagastrin | CCKBR | CCK receptor agonist | Details | |
| C04092 | BRD-K13183738 | pentamidine | TRDMT1 | anti-pneumocystis agent | Details | |
| C04093 | BRD-K40621224 | pentetic-acid | PGD | chelating agent | Details | |
| C04094 | BRD-A44448661 | pentobarbital | CHRNA4|CHRNA7|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GRIA2|GRIK2|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B | barbiturate antiepileptic; GABA receptor modulator | Details | |
| C04095 | BRD-K44942604 | pentolinium | CHRNA10|CHRNA3|CHRNA4|CHRNB4 | cholinergic receptor antagonist | Details | |
| C04096 | BRD-K91543828 | pentostatin | ADA | adenosine deaminase inhibitor; ribonucleotide reductase inhibitor | Details | |
| C04097 | BRD-K57569181 | pentoxifylline | ADORA1|ADORA2A|ADORA2B|ADRA2B|NT5E|PDE10A|PDE1A|PDE1B|PDE1C|PDE2A|PDE3A|PDE3B|PDE4A|PDE4B|PDE4C|PDE4D|PDE5A|PDE6A|PDE6B|PDE6C|PDE6D|PDE6G|PDE6H|PDE7A|PDE7B|PDE8A|PDE8B|PDE9A|TNF | phosphodiesterase inhibitor | Details | |
| C04098 | BRD-K57718010 | pentylenetetrazol | GABA receptor antagonist | Details | ||
| C04099 | BRD-K13571841 | pepstatin | CTSB|CTSD|CTSL|REN | aspartic protease inhibitor | Details | |
| C04100 | BRD-K00519864 | peramivir | neuraminidase inhibitor | Details |