CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

CMap Candidates

CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.

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Associated NAFLD Targets:

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6125 records.

CMap ID	Pert ID	Compound Name	Targets	MoA
C02901	BRD-K81053848	KS-176	ABCG2	BCRP inhibitor	Details
C02902	BRD-K66437909	KT-433		uricosuric agent	Details
C02903	BRD-K67566344	ku-0063794	MTOR	mTOR inhibitor	Details
C02904	BRD-K25311561	KU-55933	ATM\|PRKDC	ATM kinase inhibitor	Details
C02905	BRD-K36016295	KU-60019	ATM	ATM kinase inhibitor	Details
C02906	BRD-K51337109	kuromanin	CD38	ribosyl cyclase inhibitor	Details
C02907	BRD-A38747044	KU14R		imidazoline receptor antagonist	Details
C02908	BRD-K21718444	KW-2449	ABL1\|AURKA\|AURKB\|FLT3	Abl kinase inhibitor; Aurora kinase inhibitor; FLT3 inhibitor	Details
C02909	BRD-K41213548	KW-2478		HSP inhibitor	Details
C02910	BRD-A95683721	KW-3902	ADORA1\|ADORA2A\|ADORA2B\|ADORA3	adenosine receptor antagonist	Details
C02911	BRD-K29968218	KX2-391	SRC	src inhibitor; tubulin polymerization inhibitor	Details
C02912	BRD-K85872723	kynurenic-acid	GPR35\|GRIN1\|GRIN2A\|GRIN2B	glutamate receptor antagonist	Details
C02913	BRD-K13302470	KY02111	DKK1	Wnt pathway inhibitor	Details
C02914	BRD-K58568447	K02288	BMP1	bone morphogenic protein inhibitor	Details
C02915	BRD-K12106308	K145	SPHK2	sphingosine kinase inhibitor	Details
C02916	BRD-A86354194	L-(+)-Rhamnose-Monohydrate			Details
C02917	BRD-K25125382	L-alanine			Details
C02918	BRD-K76811153	L-Arginine	ARG2\|ASL\|ASS1\|AZIN2\|GPRC6A\|NOS2\|NOS3\|SLC7A1\|SLC7A3\|SLC7A4	nitric oxide precursor	Details
C02919	BRD-A45419686	L-Ascorbyl-6-palmitate			Details
C02920	BRD-K06665116	L-asparagine	ASNS\|ASRGL1\|NARS\|NARS2\|SLC1A5\|SLC38A3		Details
C02921	BRD-K82178523	L-asparagine-n-hydroxy			Details
C02922	BRD-K97163964	L-Aspartic-Acid	ACY1\|ACY3\|ADSS\|ADSSL1\|ASNS\|ASPA\|ASPH\|ASRGL1\|ASS1\|CAD\|DARS\|DARS2\|GOT1\|GOT2\|GRIN1\|GRIN2A\|GRIN2B\|GRIN2C\|GRIN2D\|LYZ\|PAICS\|RNASE1\|SLC1A1\|SLC25A12\|SLC25A13	metallic radical formation stimulant	Details
C02923	BRD-A12237696	L-Citrulline	ASS1\|DDAH1\|DDAH2\|GPRC6A\|NOS1\|NOS2\|NOS3\|OTC\|PADI1\|PADI2\|PADI3\|PADI4\|PADI6	nitric oxide stimulant	Details
C02924	BRD-K00795468	L-cysteine	CARS\|CARS2\|CBS\|CDO-1\|CDO1\|CSAD\|CTH\|GCLC\|GCLM\|GOT1\|GSS\|MGMT\|NFS1\|SLC19A3		Details
C02925	BRD-A25800195	L-Cysteinesulfinic-acid	GRM1\|GRM5\|GSR\|HMGCS2\|PAPOLA\|PRDX2	glutamate receptor agonist	Details
C02926	BRD-A15397381	L-Cystine	CTNS\|SLC3A1\|SLC7A11\|SLC7A9		Details
C02927	BRD-K26341917	L-ergothioneine		free radical scavenger	Details
C02928	BRD-K62309135	L-glutamic-acid	AADAT\|AASS\|ABAT\|ALDH18A1\|ASNS\|BCAT1\|BCAT2\|CCBL2\|DNPEP\|EARS2\|ENPEP\|EPRS\|FOLH1\|FPGS\|FTCD\|GAD1\|GAD2\|GATB\|GCLC\|GCLM\|GGCX\|GLS\|GLS2\|GLUD1\|GLUD2\|GLUL\|GMPS\|GOT1\|GOT2\|GPT\|GPT2\|GRIA1\|GRIA2\|GRIA3\|GRIA4\|GRID1\|GRID2\|GRIK1\|GRIK2\|GRIK3\|GRIK4\|GRIK5\|GRIN1\|GRIN2A\|GRIN2B\|GRIN2C\|GRIN2D\|GRIN3A\|GRIN3B\|GRM1\|GRM2\|GRM3\|GRM4\|GRM6\|GRM7\|GRM8\|LGSN\|NADSYN1\|NAGS\|OPLAH\|PFAS\|PGCP\|PSAT1\|SLC1A1\|SLC1A2\|SLC1A3\|SLC1A6\|SLC1A7\|SLC25A18\|SLC25A22\|SLC7A11\|TAT	glutamate receptor agonist	Details
C02929	BRD-A12454076	L-Hydroxyproline			Details
C02930	BRD-K12853841	L-leucine	BCAT1\|BCAT2\|LARS\|LARS2\|LCMT1\|LCMT2		Details
C02931	BRD-K86016185	L-lysine	GPRC6A\|KARS\|SLC7A1\|SLC7A2\|SLC7A3\|SLC7A4	serotonin receptor agonist	Details
C02932	BRD-K06502269	L-methionine		voltage-gated calcium channel ligand	Details
C02933	BRD-K98151021	L-mimosine	DBH\|EIF5A	dopamine beta hydroxylase inhibitor; eukaryotic translation initiation factor inhibitor	Details
C02934	BRD-K20946707	L-monomethylarginine	NOS1\|NOS2	nitric oxide synthase inhibitor	Details
C02935	BRD-K33141550	L-NAME	NOS3	nitric oxide synthase inhibitor	Details
C02936	BRD-K60036103	L-NIL	NOS1\|NOS2\|NOS3	nitric oxide synthase inhibitor	Details
C02937	BRD-K01666412	L-proline	EPRS\|L3HYPDH\|P3H1\|P3H2\|P3H3\|P4HA1\|P4HA2\|PARS2\|PPIA\|PPIB\|PPIC\|PPIF\|PPIG\|PPIH\|PRODH\|PROSC\|PYCR1\|PYCR2\|PYCRL\|SLC6A14\|SLC6A7	glutamate receptor agonist	Details
C02938	BRD-K92404805	L-Quisqualic-acid	FOLH1\|GRIA2\|GRIK1\|GRIK2\|GRM1\|GRM2\|GRM3\|GRM5\|GRM7\|GRM8	glutamate receptor agonist	Details
C02939	BRD-A08715367	L-Theanine		glutamate receptor antagonist	Details
C02940	BRD-K75508643	L-threonine	TARS\|TARS2\|THNSL1		Details
C02941	BRD-A42553870	L-152804	NPY5R	neuropeptide receptor antagonist	Details
C02942	BRD-K39733634	L-161982	PTGER4	prostanoid receptor antagonist	Details
C02943	BRD-K98372770	L-165041	PPARD	PPAR receptor agonist	Details
C02944	BRD-K18036262	L-168049	GCGR	glucagon receptor antagonist	Details
C02945	BRD-K34277641	L-365260	CCKAR\|CCKBR\|KCNQ1	CCK receptor antagonist	Details
C02946	BRD-A43930669	L-368899	AVPR1A\|AVPR2\|OXTR	oxytocin receptor antagonist	Details
C02947	BRD-K13474508	L-655,708	GABRA1\|GABRA2\|GABRA3\|GABRA5\|GABRG2	GABA receptor inverse agonist	Details
C02948	BRD-K89402695	L-655240	PTGES	thromboxane receptor antagonist	Details
C02949	BRD-A85472596	L-670596		prostanoid receptor antagonist	Details
C02950	BRD-K74284736	L-689560	GRIN1\|GRIN2A\|GRIN2B\|GRIN2C\|GRIN2D	glutamate receptor antagonist	Details
C02951	BRD-K28470988	L-690330	IMPA1	inositol monophosphatase inhibitor	Details
C02952	BRD-K83322645	L-693403	DRD2\|SIGMAR1	sigma receptor agonist; sigma receptor antagonist	Details
C02953	BRD-K18816859	L-694247	HTR1A\|HTR1B\|HTR1D	serotonin receptor agonist	Details
C02954	BRD-K10176267	L-701252	GRIN1	glutamate receptor antagonist	Details
C02955	BRD-K08109516	L-701324	GRIN1\|GRIN2A\|GRIN2B\|GRIN2C\|GRIN2D	glutamate receptor antagonist	Details
C02956	BRD-K37952347	L-732,138	TACR1\|TACR2	tachykinin antagonist	Details
C02957	BRD-K15791587	L-733060	TACR1	tachykinin antagonist	Details
C02958	BRD-K13211965	L-741742	DRD3\|DRD4\|SCN1A\|SCN3A	dopamine receptor antagonist	Details
C02959	BRD-K05528470	L-745870	DRD1\|DRD2\|DRD3\|DRD4\|HTR1A\|HTR2A\|HTR6\|HTR7	dopamine receptor antagonist	Details
C02960	BRD-K39359968	L-755507	ADRB1\|ADRB2\|ADRB3	adrenergic receptor agonist	Details
C02961	BRD-K30425481	L-760735	TACR1	tachykinin antagonist	Details
C02962	BRD-K10958118	L-778123	FNTA\|FNTB\|PGGT1B	farnesyltransferase inhibitor	Details
C02963	BRD-K43905307	L-798,106	PTGER3	prostanoid receptor antagonist	Details
C02964	BRD-K46647427	L-838417	GABRA1\|GABRA2\|GABRA3\|GABRA5	GABA receptor partial agonist	Details
C02965	BRD-A07440155	labetalol	ADRA1A\|ADRA1B\|ADRA1D\|ADRB1\|ADRB2	adrenergic receptor antagonist	Details
C02966	BRD-K43586850	lacidipine	CACNA1C	calcium channel blocker	Details
C02967	BRD-K40787673	lacitol		osmosis stimulant	Details
C02968	BRD-K68232650	lacosamide	SCN10A\|SCN11A\|SCN1A\|SCN2A\|SCN3A\|SCN4A\|SCN5A\|SCN7A\|SCN8A\|SCN9A	collapsin response mediator protein inhibitor; collapsin response mediator protein stimulant; sodium channel blocker	Details
C02969	BRD-K77258318	lactulose		laxative	Details
C02970	BRD-A67516570	lafutidine	HRH2	histamine receptor antagonist	Details
C02971	BRD-A02309928	lamivudine		nucleoside reverse transcriptase inhibitor	Details
C02972	BRD-K93460210	lamotrigine	SCN10A\|SCN11A\|SCN1A\|SCN2A\|SCN3A\|SCN4A\|SCN5A\|SCN7A\|SCN8A\|SCN9A	serotonin receptor antagonist; sodium channel blocker	Details
C02973	BRD-A64242993	lanatoside-c		cardiac glycoside	Details
C02974	BRD-K86436199	landiolol	ADRB1	adrenergic receptor antagonist	Details
C02975	BRD-A54275602	lanoconazole		sterol demethylase inhibitor	Details
C02976	BRD-A49172652	lansoprazole	ATP4A\|ATP4B	ATPase inhibitor	Details
C02977	BRD-K19687926	lapatinib	EGFR\|ERBB2	EGFR inhibitor	Details
C02978	BRD-A05906449	lappaconite		sodium channel blocker	Details
C02979	BRD-K60918217	laquinimod	CXCL2	immunosuppressant	Details
C02980	BRD-K48894757	laropiprant	PTGDR\|PTGDR2\|PTGER1\|PTGER2\|PTGER3\|PTGFR\|PTGIR\|TBXA2R	prostanoid receptor antagonist	Details
C02981	BRD-A72711497	lasalocid		bacterial permeability inducer	Details
C02982	BRD-M93148412	lasofoxifene	ESR1\|ESR2	selective estrogen receptor modulator (SERM)	Details
C02983	BRD-K10961822	latanoprost	PTGFR	prostanoid receptor agonist	Details
C02984	BRD-K55703048	latrepirdine	HRH1\|HTR6	glutamate receptor antagonist	Details
C02985	BRD-K61292460	latrunculin-b	ACTA1\|MKL1\|SPIRE2	actin polymerization inhibitor	Details
C02986	BRD-K67375056	lauric-acid	GPR84\|HNF4A\|LTF\|LY96\|PLA2G2A\|TLR4	bacterial permeability inducer	Details
C02987	BRD-K11548689	lauric-diethanolamide			Details
C02988	BRD-K35698076	laurocapram			Details
C02989	BRD-K51486818	lazabemide	MAOB	monoamine oxidase inhibitor	Details
C02990	BRD-A49767491	LB-100		protein phosphatase inhibitor	Details
C02991	BRD-K18834913	LB42708		farnesyltransferase inhibitor	Details
C02992	BRD-K08248804	LCL-161	BIRC2\|XIAP	XIAP inhibitor	Details
C02993	BRD-K20008181	LCQ908	DGAT1	diacylglycerol O acyltransferase inhibitor	Details
C02994	BRD-M31057929	LCZ696		angiotensin receptor antagonist	Details
C02995	BRD-K44715996	LDC1267	AXL\|MERTK\|TYRO3	protein tyrosine kinase inhibitor	Details
C02996	BRD-K61795638	LDN-209929	GSG2	haspin kinase inhibitor	Details
C02997	BRD-K59831625	LDN-212854	ABL1\|ACVR1\|RIPK2	bone morphogenic protein inhibitor	Details
C02998	BRD-K51485109	LDN-27219	TGM2	tissue transglutaminase inhibitor	Details
C02999	BRD-K94485812	LDN-57444		ubiquitin C-terminal hydrolase inhibitor	Details
C03000	BRD-K04853698	LDN193189	ACVR1\|BMPR1A	bone morphogenic protein inhibitor	Details