CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C01401 | BRD-K31394475 | CP-376395 | CRHR1 | corticosteroid releasing factor receptor antagonist | Details | |
| C01402 | BRD-K33234937 | CP-471474 | MMP1|MMP13|MMP2|MMP3|MMP9 | matrix metalloprotease inhibitor | Details | |
| C01403 | BRD-K36611520 | CP-532623 | CETP | cholesteryl ester transfer protein inhibitor | Details | |
| C01404 | BRD-K26921335 | CP-640186 | ACACA|ACACB | acetyl-CoA carboxylase inhibitor | Details | |
| C01405 | BRD-K43621685 | CP-673451 | KIT|PDGFRA|PDGFRB | PDGFR tyrosine kinase receptor inhibitor | Details | |
| C01406 | BRD-K76908866 | CP-724714 | ERBB2 | EGFR inhibitor; protein tyrosine kinase inhibitor | Details | |
| C01407 | BRD-K96843359 | CP-775146 | PPARA | PPAR receptor agonist | Details | |
| C01408 | BRD-K19171642 | CP-91149 | PYGL | glycogen phosphorylase inhibitor | Details | |
| C01409 | BRD-K81876028 | CP-93129 | HTR1A | serotonin receptor agonist | Details | |
| C01410 | BRD-K33860217 | CP-94253 | HTR1B | serotonin receptor agonist | Details | |
| C01411 | BRD-K09090949 | CP-945,598 | CNR1 | cannabinoid receptor antagonist | Details | |
| C01412 | BRD-K09946180 | CP-99994 | TACR1 | tachykinin antagonist | Details | |
| C01413 | BRD-A69126730 | CPA-inhibitor | CPA1|CPA2 | carboxypeptidase inhibitor | Details | |
| C01414 | BRD-A05729358 | CPCCOEt | GRM1 | glutamate receptor antagonist | Details | |
| C01415 | BRD-K19871656 | CPI-0610 | BRD4 | bromodomain inhibitor | Details | |
| C01416 | BRD-K11073688 | CPI-1189 | TNF | tumor necrosis factor release inhibitor | Details | |
| C01417 | BRD-K97181972 | CPI-169 | EZH2 | histone lysine methyltransferase inhibitor | Details | |
| C01418 | BRD-K15811707 | CPI-203 | BRD4 | bromodomain inhibitor | Details | |
| C01419 | BRD-K18319422 | CPI-360 | EZH2 | histone lysine methyltransferase inhibitor | Details | |
| C01420 | BRD-A06916187 | CPI-613 | PDHA1 | pyruvate dehydrogenase inhibitor | Details | |
| C01421 | BRD-K66094457 | CPP | GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D | glutamate receptor antagonist | Details | |
| C01422 | BRD-A81603255 | CPSI-1306-(+/-) | MIF | macrophage migration inhibiting factor inhibitor | Details | |
| C01423 | BRD-K19615002 | creatine | CKB|CKM|CKMT1A|CKMT2|GAMT|SLC6A8 | Details | ||
| C01424 | BRD-K13495773 | creatinine | Details | |||
| C01425 | BRD-K42991124 | creatinol-phosphate | Details | |||
| C01426 | BRD-K22127577 | crenolanib | CSF1R|FLT3|KIT|PDGFRA|PDGFRB | PDGFR tyrosine kinase receptor inhibitor | Details | |
| C01427 | BRD-K56940914 | cresol | Details | |||
| C01428 | BRD-K58648841 | cresopirine | Details | |||
| C01429 | BRD-K97939847 | cridanimod | PGR | progesterone receptor agonist | Details | |
| C01430 | BRD-K43230258 | crisaborole | PDE4B | phosphodiesterase inhibitor | Details | |
| C01431 | BRD-K78431006 | crizotinib | ALK|MET | ALK tyrosine kinase receptor inhibitor | Details | |
| C01432 | BRD-K40308497 | crizotinib-(S) | NUDT1 | MTH1 inhibitor | Details | |
| C01433 | BRD-K73701464 | croconazole | bacterial cell wall synthesis inhibitor | Details | ||
| C01434 | BRD-M89827113 | cromakalim | KCNJ8 | Details | ||
| C01435 | BRD-K20920669 | cromoglicic-acid | KCNMA1|S100P | immunosuppressant | Details | |
| C01436 | BRD-K57179821 | crotamiton | antipruritic | Details | ||
| C01437 | BRD-K02816415 | CRT0044876 | Details | |||
| C01438 | BRD-K33336844 | cryptotanshinone | STAT3 | acetylcholinesterase inhibitor; STAT inhibitor | Details | |
| C01439 | BRD-K60025295 | crystal-violet | other antibiotic | Details | ||
| C01440 | BRD-K40331046 | CR8-(R) | CCNA2 | CDK inhibitor | Details | |
| C01441 | BRD-K15519488 | CS-110266 | SLC6A3 | dopamine receptor agonist | Details | |
| C01442 | BRD-K35601925 | CS-917 | FBP1 | fructose biphosphate inhibitor | Details | |
| C01443 | BRD-K40870905 | CT-7758 | ITGA4 | integrin antagonist | Details | |
| C01444 | BRD-K30572193 | CTEP | GRM5 | glutamate receptor antagonist | Details | |
| C01445 | BRD-K53508936 | CTS-1027 | MMP1|MMP13|MMP2|MMP3|MMP9 | metalloproteinase inhibitor | Details | |
| C01446 | BRD-K89071957 | CTS21166 | BACE1 | beta-secretase inhibitor | Details | |
| C01447 | BRD-K58234744 | CU-CPT-4a | TLR3 | toll-like receptor inhibitor | Details | |
| C01448 | BRD-K89462779 | CU-T12-9 | TLR1|TLR2 | toll-like receptor agonist | Details | |
| C01449 | BRD-K41278234 | CUDC-101 | EGFR|ERBB2 | EGFR inhibitor | Details | |
| C01450 | BRD-K69351586 | CUDC-427 | XIAP | apoptosis inhibitor | Details | |
| C01451 | BRD-K77638923 | CUDC-907 | HDAC2|PIK3R1 | PI3K inhibitor | Details | |
| C01452 | BRD-K69624312 | CUR-61414 | DHH|IHH|SMO | smoothened receptor antagonist | Details | |
| C01453 | BRD-K07572174 | curcumin | APP|CA1|CA12|CA14|CA2|CA4|CA6|CA9|CYP3A4|DNMT3B|EP300|MMP13|MMP9|NOS2|PTGS1|PTGS2|XDH | cyclooxygenase inhibitor; histone acetyltransferase inhibitor; lipoxygenase inhibitor; NFkB pathway inhibitor | Details | |
| C01454 | BRD-K41933240 | curcumol | JAK1|JAK2|JAK3 | JAK inhibitor | Details | |
| C01455 | BRD-K90777969 | cutamesine | SIGMAR1 | sigma receptor agonist | Details | |
| C01456 | BRD-K49197823 | CV-1808 | ADORA2A | adenosine receptor agonist | Details | |
| C01457 | BRD-K60659193 | CVT-10216 | ALDH2 | aldehyde dehydrogenase inhibitor | Details | |
| C01458 | BRD-K84068331 | CW-008 | PRKACA | PKA activator | Details | |
| C01459 | BRD-K81458380 | CX-4945 | CSNK2A1|CSNK2A2|DAPK3|HIPK3 | casein kinase inhibitor | Details | |
| C01460 | BRD-K25140590 | CX-516 | glutamate receptor modulator | Details | ||
| C01461 | BRD-K12787259 | CX-5461 | RNA polymerase inhibitor | Details | ||
| C01462 | BRD-K39371216 | cyacetacide | Details | |||
| C01463 | BRD-A42881122 | cyamemazine | HTR1A|HTR2A|HTR2C|HTR7 | serotonin receptor antagonist | Details | |
| C01464 | BRD-A18627414 | cyanocobalamin | MMAA|MMACHC|MTHFR|MTR|MTRR|MUT | methylmalonyl CoA mutase stimulant; vitamin B | Details | |
| C01465 | BRD-A47884604 | cyanopindolol | ADRB1|HTR1A|HTR1D | adrenergic receptor antagonist | Details | |
| C01466 | BRD-K50785021 | cyclamic-acid | Details | |||
| C01467 | BRD-A27370296 | cyclandelate | CACNA2D1|CES1 | calcium channel blocker | Details | |
| C01468 | BRD-A41840684 | cyclic-AMP | CNGA3|HCN2|PRKAR1A|PRKAR2B|TRPM7 | Details | ||
| C01469 | BRD-K79501723 | cyclizine | HRH1|SULT1E1 | histamine receptor modulator | Details | |
| C01470 | BRD-K42348709 | cyclobenzaprine | HTR2A | adrenergic receptor agonist; serotonin receptor agonist | Details | |
| C01471 | BRD-K14379200 | cyclocreatine | creatine kinase substrate | Details | ||
| C01472 | BRD-K67536197 | cyclocytidine | DNA synthesis inhibitor; RNA synthesis inhibitor | Details | ||
| C01473 | BRD-K36055864 | cycloheximide | RPL3 | protein synthesis inhibitor | Details | |
| C01474 | BRD-A41250306 | cyclopenthiazide | thiazide diuretic | Details | ||
| C01475 | BRD-A77291778 | cyclopentolate | CHRM1 | acetylcholine receptor antagonist | Details | |
| C01476 | BRD-A09722536 | cyclophosphamide | CYP2A6|CYP2B6|CYP2C18|CYP2C19|CYP2C8|CYP2C9|CYP2D6|CYP3A4|CYP3A5|CYP3A7 | DNA alkylating agent | Details | |
| C01477 | BRD-A10420615 | cyclopiazonic-acid | ATP2A1 | ATPase inhibitor | Details | |
| C01478 | BRD-K87226815 | cycloserine-(d) | GRIN1 | bacterial cell wall synthesis inhibitor | Details | |
| C01479 | BRD-A69815203 | cyclosporin-a | PPP3CA | calcineurin inhibitor | Details | |
| C01480 | BRD-K13533483 | cyclosporine | ABCB11|CAMLG|FPR1|PPIA|PPIF|PPP3R2|SLC10A1|SLCO1B1|SLCO1B3 | calcineurin inhibitor | Details | |
| C01481 | BRD-A38675539 | cyclothiazide | CA1|CA2|CA4|FXYD2|GRIA1|GRIA2|GRIA3|GRIA4|SLC12A3 | glutamate receptor modulator | Details | |
| C01482 | BRD-K59866480 | cyclovalone | ABCG2 | breast cancer resistance protein inhibitor | Details | |
| C01483 | BRD-K27799744 | cyclovirobuxin-d | calcium channel modulator | Details | ||
| C01484 | BRD-K64866502 | CYC116 | AURKA|AURKB|KDR | Aurora kinase inhibitor | Details | |
| C01485 | BRD-K69877120 | CYM-50260 | S1PR4 | sphingosine 1 phosphate receptor agonist | Details | |
| C01486 | BRD-K80666802 | CYM-50358 | S1PR4 | sphingosine 1-phosphate receptor antagonist | Details | |
| C01487 | BRD-K27732927 | CYM-50769 | NPBWR1 | neuropeptide receptor antagonist | Details | |
| C01488 | BRD-A43005764 | CYM-5442 | S1PR1 | sphingosine 1 phosphate receptor agonist | Details | |
| C01489 | BRD-K29151923 | CYM-5520 | S1PR2 | sphingosine 1 phosphate receptor agonist | Details | |
| C01490 | BRD-K75940276 | CYM-5541 | S1PR3 | sphingosine 1 phosphate receptor agonist | Details | |
| C01491 | BRD-A62798249 | cypermethrin | Details | |||
| C01492 | BRD-K28143534 | cyproheptadine | ADRA1A|ADRA1B|ADRA1D|CHRM1|CHRM2|CHRM3|HRH1|HTR2A|HTR2C|HTR6|HTR7 | histamine receptor antagonist | Details | |
| C01493 | BRD-A48103086 | cyproterone | AR | androgen receptor antagonist | Details | |
| C01494 | BRD-K41141507 | cyproterone-acetate | ADORA1|AR | androgen receptor antagonist | Details | |
| C01495 | BRD-K36711084 | cyromazine | Details | |||
| C01496 | BRD-K92611362 | cysteamine | NPY2R|SST | tissue transglutaminase inhibitor | Details | |
| C01497 | BRD-K23363278 | CYT-997 | TUBB | tubulin polymerization inhibitor | Details | |
| C01498 | BRD-K71847383 | cytarabine | POLA1|POLB|POLD1|POLE | ribonucleotide reductase inhibitor | Details | |
| C01499 | BRD-K74186897 | cytisine | CHRNA2|CHRNA3|CHRNA4|CHRNA6|CHRNA7|CHRNB2|CHRNB4 | acetylcholine receptor agonist | Details | |
| C01500 | BRD-K47000838 | cytochalasin-b | ACTB | microtubule inhibitor | Details |