CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

CMap Candidates

CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.

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Associated NAFLD Targets:

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6125 records.

CMap ID	Pert ID	Compound Name	Targets	MoA
C01601	BRD-K01773083	denotivir		antiviral	Details
C01602	BRD-A62562325	deoxyarbutin		tyrosinase inhibitor	Details
C01603	BRD-K41170226	deoxycholic-acid	EFTUD1\|FPR1\|GPBAR1	biliverdin reductase A activator; G protein-coupled receptor agonist	Details
C01604	BRD-K24556098	deoxycorticosterone-acetate	NR3C2	progestogen hormone	Details
C01605	BRD-K33151569	deoxyepinephrine	ADRA1A\|DRD1\|DRD2	adrenergic receptor agonist; dopamine receptor agonist	Details
C01606	BRD-A65797496	deptropine	HRH1	histamine receptor antagonist	Details
C01607	BRD-K77685957	dequalinium	KCNN1\|KCNN3	PKC inhibitor	Details
C01608	BRD-K68558722	deracoxib	PTGS2	cyclooxygenase inhibitor	Details
C01609	BRD-K29462201	deserpidine	ACE\|SLC18A2	angiotensin converting enzyme inhibitor	Details
C01610	BRD-K60762818	desipramine	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C\|ADRB1\|ADRB2\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD2\|HRH1\|HTR1A\|HTR2A\|HTR2C\|SLC6A2\|SLC6A4\|SMPD1	tricyclic antidepressant	Details
C01611	BRD-K99919177	deslanoside	ATP1A1\|ATP1A2\|ATP1A3\|ATP1A4\|ATP1B1\|ATP1B2\|ATP1B3\|FXYD2	Na/K-ATPase inhibitor	Details
C01612	BRD-K82357231	desloratadine	HRH1	histamine receptor antagonist	Details
C01613	BRD-K10042277	desmethylclozapine	HTR2C	acetylcholine receptor agonist	Details
C01614	BRD-A49399758	desmopressin-acetate	AVPR1A\|AVPR1B\|AVPR2\|OXTR	vasopressin receptor agonist	Details
C01615	BRD-K46061689	desogestrel	ESR1\|PGR	progesterone receptor agonist	Details
C01616	BRD-K21528677	desonide	NR3C1\|PLA2G1B	glucocorticoid receptor agonist	Details
C01617	BRD-A49447682	desoximetasone	NR3C1\|PLA2G1B	glucocorticoid receptor agonist	Details
C01618	BRD-K26024145	desoxycorticosterone-pivalate	NR3C2	corticosteroid agonist	Details
C01619	BRD-K98521173	desoxycortone	NR3C1\|NR3C2	mineralocorticoid receptor agonist	Details
C01620	BRD-K13819402	desoxypeganine	ACHE	acetylcholinesterase inhibitor; monoamine oxidase inhibitor	Details
C01621	BRD-A98845662	desvenlafaxine	SLC6A2\|SLC6A3\|SLC6A4	serotonin norepinephrine reuptake inhibitor (SNRI)	Details
C01622	BRD-K77597856	detomidine	ADRA2A	adrenergic receptor agonist	Details
C01623	BRD-A10188456	dexamethasone	ANXA1\|NOS2\|NR0B1\|NR3C1\|NR3C2	glucocorticoid receptor agonist	Details
C01624	BRD-K47635719	dexamethasone-acetate		glucocorticoid receptor agonist	Details
C01625	BRD-A79380603	dexamethasone-sodium-phosphate	NR3C1	glucocorticoid receptor agonist	Details
C01626	BRD-K39462424	dexchlorpheniramine		histamine receptor antagonist	Details
C01627	BRD-K58626373	dexfenfluramine	HTR2C\|SLC6A4	serotonin receptor agonist	Details
C01628	BRD-K30019776	dexfosfoserine	CFTR\|GRM4\|GRM6\|GRM7\|GRM8\|KCNC4\|PDPK1\|PIM1\|PRKACA\|PRKCQ\|PYGL\|PYGM\|REG1A\|RHO\|SERPINB3\|SMAD2\|TAOK2	membrane integrity inhibitor	Details
C01629	BRD-K05900209	dexlansoprazole	ATP4A\|ATP4B	ATPase inhibitor	Details
C01630	BRD-K07609981	dexloxiglumide	CCKAR	CCK receptor antagonist	Details
C01631	BRD-K18423410	dexmedetomidine	ADRA2A\|ADRA2B\|ADRA2C	adrenergic receptor agonist	Details
C01632	BRD-K44309363	dexniguldipine	ADORA3	calmodulin antagonist	Details
C01633	BRD-K71210479	dexpanthenol			Details
C01634	BRD-K07265709	dexrazoxane	TOP2A\|TOP2B	chelating agent; topoisomerase inhibitor	Details
C01635	BRD-K67117832	dextran			Details
C01636	BRD-K21160401	dextroamphetamine	ADRA1A\|ADRA1B\|SLC18A2\|SLC6A2\|SLC6A3\|TAAR1	monoamine oxidase inhibitor	Details
C01637	BRD-K33211335	dextromethorphan	CHRNA2\|CHRNA3\|CHRNA4\|CHRNA7\|CHRNB2\|CHRNB4\|CYBA\|CYBB\|GRIN3A\|NCF1\|NCF2\|NCF4\|OPRD1\|OPRK1\|OPRM1\|PGRMC1\|RAC1\|RAC2\|SIGMAR1\|SLC6A2\|SLC6A4	glutamate receptor antagonist; sigma receptor agonist	Details
C01638	BRD-K51431759	dextrose			Details
C01639	BRD-K82002057	DFB	GRM5	glutamate receptor agonist	Details
C01640	BRD-K75748943	DG-172	PPARD	PPAR receptor inverse agonist	Details
C01641	BRD-K06014311	DH-97	MTNR1B	melatonin receptor antagonist	Details
C01642	BRD-K41262162	DHBP		ryanodine receptor blocker	Details
C01643	BRD-K69122748	diacerein	IL1B	interleukin inhibitor	Details
C01644	BRD-K93611241	diacetamate			Details
C01645	BRD-A15035311	diadenosine-tetraphosphate	P2RY13\|P2RY2	adenosine kinase inhibitor	Details
C01646	BRD-K68502831	dianhydrogalactitol		DNA alkylating agent	Details
C01647	BRD-A27143604	diarylpropionitrile	ESR2	estrogen receptor agonist	Details
C01648	BRD-K48247567	diatrizoic-acid			Details
C01649	BRD-K97464279	diaveridine		dihydrofolate reductase inhibitor	Details
C01650	BRD-K16508793	diazepam	ADRA1A\|GABRA1\|GABRA2\|GABRA3\|GABRA4\|GABRA5\|GABRA6\|GABRB1\|GABRB2\|GABRB3\|GABRD\|GABRE\|GABRG1\|GABRG2\|GABRG3\|GABRP\|GABRQ\|GABRR1\|GABRR2\|GABRR3\|TSPO	benzodiazepine receptor agonist	Details
C01651	BRD-K38458514	diazooxonorleucine		glutamate receptor antagonist	Details
C01652	BRD-K73109821	diazoxide	ATP1A1\|CA1\|CA2\|KCNJ11\|KCNJ8\|KCNMA1\|SLC12A3	potassium channel activator	Details
C01653	BRD-K48427910	dibekacin		bacterial 30S ribosomal subunit inhibitor	Details
C01654	BRD-K79145749	dibenzepine		norepinephrine reputake inhibitor	Details
C01655	BRD-K46863940	dibenzothiophene			Details
C01656	BRD-K73477617	dibutyl-phthalate	TRPA1		Details
C01657	BRD-K54187111	dichlorisone-acetate			Details
C01658	BRD-M97302542	dichloroacetate	PDK1	pyruvate dehydrogenase kinase inhibitor	Details
C01659	BRD-K62326629	dichlorophen		anticestodal agent	Details
C01660	BRD-K23779958	dichlorvos		acetylcholinesterase inhibitor	Details
C01661	BRD-A06426627	diclazuril		antiprotozoal agent	Details
C01662	BRD-K08252256	diclofenac	AKR1C3\|ALOX5\|ASIC1\|ASIC3\|KCNQ2\|KCNQ3\|PLA2G2A\|PPARG\|PTGS1\|PTGS2\|SCN4A	cyclooxygenase inhibitor	Details
C01663	BRD-K71499074	diclofenamide	CA1\|CA12\|CA2\|CA4\|CA7	carbonic anhydrase inhibitor	Details
C01664	BRD-A51078674	diclofensine	DRD1\|MAOA\|MAOB	dopamine reuptake inhibitor	Details
C01665	BRD-A41657926	dicloralurea			Details
C01666	BRD-K05673000	dicloxacillin		bacterial cell wall synthesis inhibitor	Details
C01667	BRD-K82236179	dicoumarol	CRYZ\|NQO1\|VKORC1	NADPH inhibitor	Details
C01668	BRD-K57091285	dicyclohexylamine			Details
C01669	BRD-K68507560	dicycloverine	CHRM1\|CHRM2\|CHRM3	acetylcholine receptor antagonist	Details
C01670	BRD-K99063460	didanosine	PNP	nucleoside reverse transcriptase inhibitor	Details
C01671	BRD-K84794093	dideoxyadenosine		nucleoside reverse transcriptase inhibitor	Details
C01672	BRD-K94146583	didox	RRM1	ribonucleotide reductase inhibitor	Details
C01673	BRD-K95309561	dienestrol	ESR1	estrogen receptor agonist	Details
C01674	BRD-K50853363	dienogest	PGR	progesterone receptor agonist	Details
C01675	BRD-K45542189	diethylcarbamazine	ALOX5\|PTGS1	lipoxygenase inhibitor	Details
C01676	BRD-K45330754	diethylstilbestrol	ESR1\|ESR2\|ESRRB\|ESRRG	estrogen receptor agonist	Details
C01677	BRD-K94080537	diethyltoluamide		ionotropic receptor IR40a activator	Details
C01678	BRD-K96206066	difenpiramide		cyclooxygenase inhibitor; prostaglandin inhibitor	Details
C01679	BRD-A66869276	diflorasone-diacetate	NR3C1	glucocorticoid receptor agonist	Details
C01680	BRD-K73923631	difloxacin		bacterial DNA gyrase inhibitor	Details
C01681	BRD-K22031190	diflunisal	PTGS1\|PTGS2	prostanoid receptor antagonist	Details
C01682	BRD-K33720171	difluprednate	NR3C1	glucocorticoid receptor agonist	Details
C01683	BRD-K80076813	diftalone		cyclooxygenase inhibitor	Details
C01684	BRD-K18518344	digitoxigenin	ATP1A1	ATPase inhibitor	Details
C01685	BRD-A93236127	digitoxin	ATP1A1	ATPase inhibitor	Details
C01686	BRD-K18619710	digoxigenin		steroid	Details
C01687	BRD-A94756469	digoxin	ATP1A1	ATPase inhibitor	Details
C01688	BRD-K20152659	dihomo-gamma-linolenic-acid	PTGS1\|PTGS2	prostanoid receptor agonist	Details
C01689	BRD-K31471398	dihydrexidine	DRD1\|DRD2\|DRD3\|DRD4\|DRD5	dopamine receptor agonist	Details
C01690	BRD-K62213621	dihydroartemisinin		antimalarial agent	Details
C01691	BRD-K97440753	dihydroergocristine	ADRA1A\|ADRB1\|DRD1\|DRD2\|DRD3\|DRD4\|DRD5\|HTR1A\|HTR2A\|HTR3A\|HTR4\|HTR5A\|HTR6\|HTR7	adrenergic receptor antagonist; prolactin inhibitor	Details
C01692	BRD-K72166146	dihydroergotamine	ADRA2A\|DRD2\|HTR1B\|HTR1D\|HTR1E\|HTR1F\|HTR2B\|HTR7	serotonin receptor agonist	Details
C01693	BRD-K01614093	dihydromyricetin			Details
C01694	BRD-A67363467	dihydrostreptomycin		bacterial 30S ribosomal subunit inhibitor	Details
C01695	BRD-A34455052	dihydrotachysterol	VDR	vitamin analog	Details
C01696	BRD-K22525962	dihydrotestosterone	AR\|HSD17B1	androgen receptor agonist	Details
C01697	BRD-K18637542	dihydroxyacetone			Details
C01698	BRD-A20589515	dihydroxyphenylglycine	GRM1\|GRM5	glutamate receptor agonist	Details
C01699	BRD-K36802417	diiodothyropropionic-acid		thyroid hormone stimulant	Details
C01700	BRD-K48722258	dilazep	SLC29A1	adenosine reuptake inhibitor	Details