CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C01901 | BRD-K28982731 | emoxipin | Details | |||
| C01902 | BRD-K53765467 | empagliflozin | SLC5A1|SLC5A2 | sodium/glucose cotransporter inhibitor | Details | |
| C01903 | BRD-K61452026 | emtricitabine | nucleoside reverse transcriptase inhibitor | Details | ||
| C01904 | BRD-K57545991 | enalapril | ACE | angiotensin converting enzyme inhibitor | Details | |
| C01905 | BRD-K99447003 | enalaprilat | ACE | angiotensin converting enzyme inhibitor | Details | |
| C01906 | BRD-K70601687 | enasidenib | IDH1 | isocitrate dehydrogenase inhibitor | Details | |
| C01907 | BRD-K66918327 | enbucrilate | Details | |||
| C01908 | BRD-A62197763 | enciprazine | GABRA1 | GABA receptor modulator | Details | |
| C01909 | BRD-K61314889 | endo-IWR-1 | TNKS|TNKS2 | PARP inhibitor | Details | |
| C01910 | BRD-K62752296 | endoxifen | ESR1 | estrogen receptor antagonist | Details | |
| C01911 | BRD-A51831848 | enflurane | ATP2C1|ATP5D|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GLRA1|GLRB|GRIA1|KCNA1|KCNK10|KCNK18|KCNK2|KCNK3|KCNK9|KCNN4 | membrane permeability inhibitor | Details | |
| C01912 | BRD-A11776908 | enilconazole | CYP19A1|CYP1A2|CYP2B6|CYP2C9|CYP2J2|CYP3A4|CYP3A5|NR1I2|PPARA|PTGER2 | sterol demethylase inhibitor | Details | |
| C01913 | BRD-K26425819 | eniluracil | AOX1|DPYD|XDH | dihydropyrimidine dehydrogenase inhibitor | Details | |
| C01914 | BRD-K10029415 | enisamium-iodide | Details | |||
| C01915 | BRD-K68488863 | ENMD-2076 | AURKA|FLT3|KDR|PDGFRA|PTK2|SRC | Aurora kinase inhibitor; FLT3 inhibitor; VEGFR inhibitor | Details | |
| C01916 | BRD-K32007074 | enocitabine | CMPK1|RRM1|TYMS | DNA synthesis inhibitor | Details | |
| C01917 | BRD-K78113049 | enoxacin | TOP2A | topoisomerase inhibitor | Details | |
| C01918 | BRD-K21152241 | enoximone | PDE3A | phosphodiesterase inhibitor | Details | |
| C01919 | BRD-K96137854 | enoxolone | HSD11B1 | gap junction modulator | Details | |
| C01920 | BRD-K35007173 | enprofylline | ADORA1|ADORA2A|ADORA2B|ADORA3|PDE4A|PDE4B | phosphodiesterase inhibitor | Details | |
| C01921 | BRD-K76534306 | enrofloxacin | bacterial DNA gyrase inhibitor | Details | ||
| C01922 | BRD-K83636919 | entacapone | COMT | catechol O methyltransferase inhibitor | Details | |
| C01923 | BRD-K08206212 | entecavir | DNA replication inhibitor; nucleoside reverse transcriptase inhibitor | Details | ||
| C01924 | BRD-K77908580 | entinostat | HDAC1|HDAC2|HDAC3|HDAC9 | HDAC inhibitor | Details | |
| C01925 | BRD-K39009484 | entrectinib | ALK|NTRK1|NTRK2|NTRK3|ROS1 | ALK tyrosine kinase receptor inhibitor; proto-oncogene tyrosine protein kinase inhibitor | Details | |
| C01926 | BRD-K56851771 | enzalutamide | AR | androgen receptor antagonist | Details | |
| C01927 | BRD-K79404599 | enzastaurin | AKT1|GSK3B|PRKCA|PRKCB|PRKCD|PRKCG | PKC inhibitor | Details | |
| C01928 | BRD-K86063171 | EN460 | ERO1A | endoplasmic reticulum oxidation inhibitor | Details | |
| C01929 | BRD-K42452249 | EO-1428 | MAPK11|MAPK14 | p38 MAPK inhibitor | Details | |
| C01930 | BRD-K79450420 | epacadostat | IDO1 | indoleamine 2,3-dioxygenase inhibitor | Details | |
| C01931 | BRD-K98054437 | epalrestat | AKR1B1 | aldose reductase inhibitor | Details | |
| C01932 | BRD-K47554101 | eperezolid | bacterial 30S ribosomal subunit inhibitor | Details | ||
| C01933 | BRD-A04252265 | eperisone | CYP2J2 | acetylcholine receptor antagonist | Details | |
| C01934 | BRD-K45014108 | ephedrine | ACHE|ADRA1A|ADRB2|SLC18A2|SLC6A2 | adrenergic receptor agonist | Details | |
| C01935 | BRD-A54236247 | ephedrine-(racemic) | ADRA1A|ADRA2A | adrenergic receptor agonist | Details | |
| C01936 | BRD-K42756753 | epiandrosterone | G6PD | steroid | Details | |
| C01937 | BRD-K50660797 | epicatechin-gallate-(-) | BACE1|FASN | bacterial DNA gyrase inhibitor | Details | |
| C01938 | BRD-K55591206 | epigallocatechin-gallate-(-) | ELANE|EP300|FASN|KAT2B|MMP14|MMP2 | bacterial DNA gyrase inhibitor | Details | |
| C01939 | BRD-A98990573 | epinastine | ADRA1A|ADRA2A|HRH1|HRH2|HTR2A|HTR7 | histamine receptor antagonist | Details | |
| C01940 | BRD-K63126190 | epinephrine | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|ADRB3|PAH|TNF | adrenergic receptor agonist; neurotransmitter | Details | |
| C01941 | BRD-A07765530 | epinephrine-(racemic) | carbonic anhydrase activator | Details | ||
| C01942 | BRD-K39339537 | epirizole | PTGS1|PTGS2 | cyclooxygenase inhibitor | Details | |
| C01943 | BRD-K04548931 | epirubicin | CHD1|TOP2A | topoisomerase inhibitor | Details | |
| C01944 | BRD-K02314383 | epitiostanol | AR | androgen receptor agonist | Details | |
| C01945 | BRD-K19761926 | eplerenone | NR3C2 | cytochrome P450 inhibitor | Details | |
| C01946 | BRD-A59329714 | epomediol | CYP7A1 | cholesterol inhibitor | Details | |
| C01947 | BRD-K64054020 | epoprostenol | P2RY12|PTGER1|PTGER4|PTGIR|PTGIS | prostacyclin analog | Details | |
| C01948 | BRD-K71823332 | epothilone-a | microtubule stabilizing agent | Details | ||
| C01949 | BRD-K68164687 | epothilone-b | TUBA1A|TUBA1B|TUBA1C|TUBA3C|TUBA4A|TUBA8|TUBB|TUBB1|TUBB3|TUBB4A|TUBB4B | microtubule stabilizing agent; tubulin polymerization inhibitor | Details | |
| C01950 | BRD-K52762805 | epothilone-d | TUBA1A|TUBA1B|TUBA1C|TUBA3C|TUBA4A|TUBA8|TUBB|TUBB1|TUBB3|TUBB4A|TUBB4B | microtubule stabilizing agent; tubulin polymerization inhibitor | Details | |
| C01951 | BRD-K42536037 | EPPTB | TAAR1 | trace amine associated receptor antagonist | Details | |
| C01952 | BRD-A72212290 | eprazinone | mucolytic agent | Details | ||
| C01953 | BRD-A91366704 | eprinomectin | benzodiazepine receptor agonist | Details | ||
| C01954 | BRD-K17979676 | eprobemide | MAOA | monoamine oxidase inhibitor | Details | |
| C01955 | BRD-K11463116 | eprodisate | SAA1 | antiamyloidogenic agent; amyloid protein inhibitor | Details | |
| C01956 | BRD-K67977190 | eprosartan | AGTR1 | angiotensin receptor antagonist | Details | |
| C01957 | BRD-A90547603 | eptifibatide | ITGA2B|ITGB3 | platelet aggregation inhibitor | Details | |
| C01958 | BRD-K26531771 | EPZ-5676 | DOT1L | histone lysine methyltransferase inhibitor | Details | |
| C01959 | BRD-K69070623 | EPZ004777 | DOT1L | histone lysine methyltransferase inhibitor | Details | |
| C01960 | BRD-K57754230 | EPZ005687 | EZH2 | histone lysine methyltransferase inhibitor | Details | |
| C01961 | BRD-K87468701 | EPZ011989 | EZH2 | histone lysine methyltransferase inhibitor | Details | |
| C01962 | BRD-K70446295 | EPZ015666 | PRMT5 | protein arginine N-methyltransferase inhibitor | Details | |
| C01963 | BRD-K33586289 | EPZ020411 | PRMT6 | protein arginine N-methyltransferase inhibitor | Details | |
| C01964 | BRD-A88080608 | equilin | HSD17B1 | estrogen receptor agonist | Details | |
| C01965 | BRD-K54847683 | equol | ESR1|ESR2 | estrogen receptor agonist | Details | |
| C01966 | BRD-K11927976 | ER-27319 | SYK | mediator release inhibitor; SYK inhibitor | Details | |
| C01967 | BRD-K18347943 | ER-50891 | RARA | retinoid receptor antagonist | Details | |
| C01968 | BRD-A25004090 | erastin | VDAC2 | ion channel antagonist | Details | |
| C01969 | BRD-K35573744 | erbstatin-analog | EGFR | EGFR inhibitor; tyrosine kinase inhibitor | Details | |
| C01970 | BRD-K84163249 | ercalcitriol | VDR | vitamin D receptor agonist | Details | |
| C01971 | BRD-K84868168 | erdafitinib | FGFR1|FGFR2|FGFR3|FGFR4 | FGFR inhibitor | Details | |
| C01972 | BRD-A05515753 | erdosteine | mucolytic agent | Details | ||
| C01973 | BRD-K56155962 | ergocalciferol | VDR | vitamin analog | Details | |
| C01974 | BRD-A26387268 | ergonovine | ADRA1A|HTR1E | adrenergic receptor agonist; serotonin receptor agonist | Details | |
| C01975 | BRD-K03039262 | ergosterol | vitamin D precursor | Details | ||
| C01976 | BRD-A43227343 | ergotamine | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|DRD1|DRD2|DRD5|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR5A|HTR6|SLC6A2 | adrenergic receptor antagonist | Details | |
| C01977 | BRD-K64857848 | ERK5-IN-1 | MAPK7 | MAP kinase inhibitor | Details | |
| C01978 | BRD-K70401845 | erlotinib | EGFR|NR1I2 | EGFR inhibitor | Details | |
| C01979 | BRD-A40472231 | ertapenem | bacterial cell wall synthesis inhibitor | Details | ||
| C01980 | BRD-K80608265 | erteberel | ESR1|ESR2 | estrogen receptor agonist | Details | |
| C01981 | BRD-K10071630 | ertugliflozin | SLC5A2 | sodium/glucose cotransporter inhibitor | Details | |
| C01982 | BRD-K79315489 | erythritol | Details | |||
| C01983 | BRD-K63550407 | erythromycin | MLNR | NFkB pathway inhibitor | Details | |
| C01984 | BRD-K39746403 | erythromycin-estolate | ABCB1|ALB|CYP3A4|CYP51A1|KCNH2|MLNR|SLC47A1 | bacterial 50S ribosomal subunit inhibitor | Details | |
| C01985 | BRD-K51677086 | erythromycin-ethylsuccinate | ABCB1|ALB|CYP3A4|CYP51A1|KCNH2|MLNR|SLC47A1 | cytochrome P450 inhibitor; protein synthesis inhibitor | Details | |
| C01986 | BRD-K14920963 | erythrosine | coloring agent | Details | ||
| C01987 | BRD-K92426617 | esaprazole | Details | |||
| C01988 | BRD-A90796352 | escin | nitric oxide synthase stimulant | Details | ||
| C01989 | BRD-K70301876 | escitalopram | ADRA1A|CHRM1|HRH1|SLC6A2|SLC6A3|SLC6A4 | selective serotonin reuptake inhibitor (SSRI) | Details | |
| C01990 | BRD-K36270037 | esculin | antioxidant | Details | ||
| C01991 | BRD-K13629382 | eseroline-(-) | OPRD1|OPRM1 | acetylcholinesterase inhibitor | Details | |
| C01992 | BRD-K77139516 | ESI-09 | RAPGEF3|RAPGEF4 | EPAC inhibitor | Details | |
| C01993 | BRD-K61237927 | eslicarbazepine-acetate | SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A | sodium channel blocker | Details | |
| C01994 | BRD-A07395371 | esmolol | ADRB1 | adrenergic receptor antagonist | Details | |
| C01995 | BRD-K61443506 | esomeprazole | ATP4A | ATPase inhibitor | Details | |
| C01996 | BRD-K75445017 | estetrol | ESR1 | selective estrogen receptor modulator (SERM) | Details | |
| C01997 | BRD-K18910433 | estradiol | ESR1|ESR2|GPER1|KCNMA1|NR1I2 | estrogen receptor agonist | Details | |
| C01998 | BRD-K53319039 | estradiol-acetate | ESR1 | estrogen receptor agonist | Details | |
| C01999 | BRD-A74765037 | estradiol-benzoate | ESR1 | contraceptive agent | Details | |
| C02000 | BRD-A91452556 | estradiol-cypionate | ESR1 | estrogen receptor agonist | Details |