CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
stats1
stats2
6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C00501 | BRD-K77012840 | AY-9944 | hedgehog pathway modulator | Details | ||
| C00502 | BRD-K36258877 | AZ-10417808 | CASP3 | caspase inhibitor | Details | |
| C00503 | BRD-K09907507 | AZ-10606120 | P2RX7 | purinergic receptor antagonist | Details | |
| C00504 | BRD-K05973499 | AZ-12080282 | DHH | hedgehog pathway inhibitor | Details | |
| C00505 | BRD-K05804044 | AZ-628 | BRAF|RAF1 | RAF inhibitor | Details | |
| C00506 | BRD-K03406345 | azacitidine | DNMT1|DNMT3A | DNA methyltransferase inhibitor | Details | |
| C00507 | BRD-K97061094 | azacyclonol | HRH1 | histamine receptor antagonist | Details | |
| C00508 | BRD-K53114651 | azaguanine-8 | PNP | purine antagonist | Details | |
| C00509 | BRD-K96104201 | azalomycin-b | bacterial 50S ribosomal subunit inhibitor | Details | ||
| C00510 | BRD-K45861246 | azaperone | DRD2|DRD3 | dopamine receptor antagonist | Details | |
| C00511 | BRD-A70182876 | azapropazone | PTGS2 | cyclooxygenase inhibitor | Details | |
| C00512 | BRD-A67065070 | azaserine | purine antagonist | Details | ||
| C00513 | BRD-A44133049 | azasetron | HTR3A|HTR3B | serotonin receptor antagonist | Details | |
| C00514 | BRD-K77821588 | azatadine | HRH1 | histamine receptor antagonist | Details | |
| C00515 | BRD-K32821942 | azathioprine | HPRT1|IMPDH1|PPAT | dehydrogenase inhibitor | Details | |
| C00516 | BRD-K61041538 | AZD1080 | GSK3A|GSK3B | glycogen synthase kinase inhibitor | Details | |
| C00517 | BRD-K21908111 | AZD1208 | PIM1|PIM2|PIM3 | Pim kinase inhibitor | Details | |
| C00518 | BRD-K77060810 | AZD1283 | P2RY12 | purinergic receptor antagonist | Details | |
| C00519 | BRD-A44188509 | AZD1446 | CHRNA4|CHRNB2 | acetylcholine receptor agonist | Details | |
| C00520 | BRD-K65928735 | AZD1480 | JAK1|JAK2|JAK3 | JAK inhibitor | Details | |
| C00521 | BRD-K83186168 | AZD1981 | PTGDR2 | CRTH receptor antagonist | Details | |
| C00522 | BRD-K99113996 | AZD2014 | MTOR | mTOR inhibitor | Details | |
| C00523 | BRD-K85014146 | AZD2461 | PARP inhibitor | Details | ||
| C00524 | BRD-K85849709 | AZD2858 | GSK3B | glycogen synthase kinase inhibitor | Details | |
| C00525 | BRD-K14287049 | AZD3264 | IKBKB | IKK inhibitor | Details | |
| C00526 | BRD-K24593301 | AZD3463 | ALK|IGF1R | ALK tyrosine kinase receptor inhibitor; insulin growth factor receptor inhibitor | Details | |
| C00527 | BRD-K84996356 | AZD3514 | AR | androgen receptor modulator | Details | |
| C00528 | BRD-K41626799 | AZD3759 | EGFR | EGFR inhibitor | Details | |
| C00529 | BRD-A54654253 | AZD3839 | BACE1 | beta-secretase inhibitor | Details | |
| C00530 | BRD-K25210703 | AZD3965 | SLC16A1 | monocarboxylate transporter inhibitor | Details | |
| C00531 | BRD-K73984371 | AZD3988 | DGAT1 | diacylglycerol kinase inhibitor | Details | |
| C00532 | BRD-K72369578 | AZD4282 | AGXT|AGXT2|ALAS1|ALAS2|BAAT|GARS|GATM|GCAT|GCSH|GLDC|GLRA1|GLRA2|GLRA3|GLRB|GLYAT|GLYATL1|GLYATL2|GNMT|GPR18|GPRC6A|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3B|GSS|PIPOX|SHMT1|SHMT2|SLC32A1|SLC36A1|SLC6A5|SLC6A9 | glutamate receptor antagonist | Details | |
| C00533 | BRD-K28392481 | AZD4547 | FGFR1|FGFR2|FGFR3|FGFR4|IGF1R|KDR | FGFR inhibitor | Details | |
| C00534 | BRD-K34801930 | AZD5069 | CXCR2 | CC chemokine receptor antagonist | Details | |
| C00535 | BRD-K99023089 | AZD5363 | AKT1|AKT2|AKT3 | AKT inhibitor | Details | |
| C00536 | BRD-K72414522 | AZD5438 | KCNH2 | CDK inhibitor | Details | |
| C00537 | BRD-K88767641 | AZD5582 | BIRC2|BIRC3|XIAP | XIAP inhibitor | Details | |
| C00538 | BRD-K58772419 | AZD6482 | PIK3CA|PIK3CB|PIK3CD|PIK3CG | PI3K inhibitor | Details | |
| C00539 | BRD-A36013532 | AZD6738 | ATR | ATR kinase inhibitor | Details | |
| C00540 | BRD-A94033181 | AZD6765 | GRIN1 | glutamate receptor antagonist | Details | |
| C00541 | BRD-A87435144 | AZD7545 | PDK1 | pyruvate dehydrogenase kinase inhibitor | Details | |
| C00542 | BRD-K31495718 | AZD7687 | DGAT1 | diacylglycerol O acyltransferase inhibitor | Details | |
| C00543 | BRD-K86525559 | AZD7762 | CHEK1|CHEK2 | CHK inhibitor | Details | |
| C00544 | BRD-K69932463 | AZD8055 | MTOR | mTOR inhibitor | Details | |
| C00545 | BRD-K47289408 | AZD8186 | PIK3CB|PIK3CD | PI3K inhibitor | Details | |
| C00546 | BRD-K37687095 | AZD8330 | MEK inhibitor | Details | ||
| C00547 | BRD-K82894950 | AZD8835 | PIK3CA|PIK3CD | PI3K inhibitor | Details | |
| C00548 | BRD-K98572433 | AZD8931 | EGFR|ERBB2|ERBB3 | EGFR inhibitor | Details | |
| C00549 | BRD-K61043483 | AZD9272 | GRM5 | glutamate receptor antagonist | Details | |
| C00550 | BRD-K73235735 | AZD9496 | ESR1 | estrogen receptor agonist | Details | |
| C00551 | BRD-K31476763 | AZD9668 | ELANE | elastase inhibitor | Details | |
| C00552 | BRD-K08976401 | azelaic-acid | AKR1D1|SRD5A2|TYR | tyrosinase inhibitor | Details | |
| C00553 | BRD-A68888262 | azelastine | HRH1 | histamine receptor antagonist | Details | |
| C00554 | BRD-K51899933 | azeliragon | AGER | RAGE receptor antagonist | Details | |
| C00555 | BRD-A01098288 | azelnidipine | CACNA1C | calcium channel blocker | Details | |
| C00556 | BRD-K81074237 | azilsartan | AGTR1|AGTR2 | angiotensin receptor antagonist | Details | |
| C00557 | BRD-K25723200 | azilsartan-medoxomil | AGTR1|AGTR2 | angiotensin receptor antagonist | Details | |
| C00558 | BRD-K38913877 | azimilide | KCNA5|KCNE1|KCNH2|KCNQ1 | potassium channel blocker | Details | |
| C00559 | BRD-K74501079 | azithromycin | MLNR | bacterial 50S ribosomal subunit inhibitor | Details | |
| C00560 | BRD-K60663764 | azlocillin | bacterial cell wall synthesis inhibitor | Details | ||
| C00561 | BRD-K51329597 | AZM-475271 | SRC | src inhibitor | Details | |
| C00562 | BRD-K87036601 | azodicarbonamide | DNA synthesis inhibitor | Details | ||
| C00563 | BRD-K26824830 | azomycin-(2-nitroimidazole) | protein synthesis inhibitor | Details | ||
| C00564 | BRD-K68770713 | azosemide | SLC12A1|SLC12A2 | electrolyte reabsorption inhibitor | Details | |
| C00565 | BRD-K62607865 | aztreonam | bacterial cell wall synthesis inhibitor | Details | ||
| C00566 | BRD-K80935598 | AZ191 | DYRK1B | DYRK inhibitor | Details | |
| C00567 | BRD-K42436189 | AZ20 | ATR|MTOR | ATR kinase inhibitor | Details | |
| C00568 | BRD-K59146805 | AZ3146 | monopolar spindle 1 kinase inhibitor | Details | ||
| C00569 | BRD-K76244476 | AZ505 | SMYD2 | histone lysine methyltransferase inhibitor | Details | |
| C00570 | BRD-K81958169 | AZ5104 | EGFR | EGFR inhibitor | Details | |
| C00571 | BRD-K64888243 | AZ960 | JAK2 | JAK inhibitor | Details | |
| C00572 | BRD-K57865272 | A0001 | Details | |||
| C00573 | BRD-A30000356 | A12B4C3 | PNKP | polynucleotide kinase/phosphatase inhibitor | Details | |
| C00574 | BRD-K77627880 | A205804 | ICAM1|SELE | ICAM1 expression inhibitor | Details | |
| C00575 | BRD-A83650191 | A61603 | ADRA1A | adrenergic receptor agonist | Details | |
| C00576 | BRD-K49055432 | A66 | PIK3CA | PI3K inhibitor | Details | |
| C00577 | BRD-A78952587 | A740003 | P2RX7 | purinergic receptor antagonist | Details | |
| C00578 | BRD-K72226571 | A77636 | CALY | dopamine receptor agonist | Details | |
| C00579 | BRD-K28861668 | A922500 | DGAT1 | diacylglycerol O acyltransferase inhibitor | Details | |
| C00580 | BRD-A41698174 | bacampicillin | bacterial cell wall synthesis inhibitor | Details | ||
| C00581 | BRD-A49374018 | bacitracin | A2M|IDE | bacterial cell wall synthesis inhibitor | Details | |
| C00582 | BRD-A06016120 | bacitracin-zinc | bacterial cell wall synthesis inhibitor | Details | ||
| C00583 | BRD-A84174873 | baclofen | GABBR1|GABBR2|KCTD12|KCTD16|KCTD8 | benzodiazepine receptor agonist | Details | |
| C00584 | BRD-K62353271 | baclofen-(R) | GABBR1|GABBR2 | benzodiazepine receptor agonist | Details | |
| C00585 | BRD-A16694057 | BADGE | PPARG | PPAR receptor antagonist | Details | |
| C00586 | BRD-A75975749 | bafetinib | ABL1|BCR|LYN | Bcr-Abl kinase inhibitor; LYN tyrosine kinase inhibitor | Details | |
| C00587 | BRD-K00652956 | BAG-956 | PIK3CG | phosphoinositide dependent kinase inhibitor | Details | |
| C00588 | BRD-K72327355 | baicalein | ALOX5|GLO1|PREP|SELL|SELP|TNF|XDH | lipoxygenase inhibitor | Details | |
| C00589 | BRD-K49962337 | baicalin | PREP | beta glucuronidase inhibitor | Details | |
| C00590 | BRD-K09785578 | bakuchiol | HIF1A | DNA polymerase inhibitor | Details | |
| C00591 | BRD-A00147595 | balaglitazone | PPARG | insulin sensitizer; PPAR receptor partial agonist | Details | |
| C00592 | BRD-K47976015 | balapiravir | RNA polymerase inhibitor | Details | ||
| C00593 | BRD-K27204852 | balicatib | CTSK | cathepsin inhibitor | Details | |
| C00594 | BRD-A47790386 | balofloxacin | bacterial DNA gyrase inhibitor | Details | ||
| C00595 | BRD-K41410256 | balsalazide | ALOX5|PPARG|PTGS1|PTGS2 | cyclooxygenase inhibitor | Details | |
| C00596 | BRD-A17462676 | bambuterol | ADRB2|BCHE | adrenergic receptor agonist | Details | |
| C00597 | BRD-K07442505 | BAM7 | BAX | BAX activator | Details | |
| C00598 | BRD-K47049295 | BAN-ORL-24 | OPRL1 | nociceptin/orphanin FQ receptor antagonist | Details | |
| C00599 | BRD-K31928526 | barasertib | AURKA|AURKB | Aurora kinase inhibitor | Details | |
| C00600 | BRD-K63923597 | barasertib-HQPA | AURKB | Aurora kinase inhibitor | Details |