CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

CMap Candidates

CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.

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PPAR

73 records.

CMap ID	Pert ID	Compound Name	Targets	MoA
C00074	BRD-K79437791	acetyl-farnesyl-cysteine	PPARG	methyltransferase inhibitor	Details
C00585	BRD-A16694057	BADGE	PPARG	PPAR receptor antagonist	Details
C00591	BRD-A00147595	balaglitazone	PPARG	insulin sensitizer; PPAR receptor partial agonist	Details
C00595	BRD-K41410256	balsalazide	ALOX5\|PPARG\|PTGS1\|PTGS2	cyclooxygenase inhibitor	Details
C00602	BRD-K20545304	bardoxolone	NOS2\|PPARG	nuclear factor erythroid derived; like (NRF2) activator	Details
C00603	BRD-K69694239	bardoxolone-methyl	PPARG\|STAT3	nuclear factor erythroid derived; like (NRF2) activator	Details
C00721	BRD-K46018455	bezafibrate	PPARA\|PPARD\|PPARG	PPAR receptor agonist	Details
C00767	BRD-K41494493	bisphenol-a	AR\|ESR1\|ESR2\|ESRRG\|PPARG	synthetic estrogen	Details
C01125	BRD-K86954340	cetaben	PPARA	cholesterol inhibitor; ACAT inhibitor	Details
C01247	BRD-A93000692	ciglitazone	PPARG	PPAR receptor agonist	Details
C01275	BRD-K24570280	CINPA-1	NR1H4\|NR1I3\|PPARG	CAR antagonist	Details
C01279	BRD-A49358627	ciprofibrate	PPARA	PPAR receptor agonist	Details
C01331	BRD-K45252063	clofibrate	LPL\|PPARA	PPAR receptor agonist	Details
C01332	BRD-K19111024	clofibric-acid	PPARA	PPAR receptor agonist	Details
C01407	BRD-K96843359	CP-775146	PPARA	PPAR receptor agonist	Details
C01553	BRD-K82908348	darglitazone	PPARG	PPAR receptor antagonist	Details
C01588	BRD-K41256143	dehydroepiandrosterone	ESR1\|ESR2\|G6PD\|GABRA1\|GABRA2\|GABRA3\|GABRA4\|GABRA5\|GABRA6\|GABRB1\|GABRB2\|GABRB3\|GABRD\|GABRE\|GABRG1\|GABRG2\|GABRG3\|GABRP\|GABRQ\|GRIN1\|GRIN2A\|GRIN2B\|GRIN2C\|GRIN2D\|GRIN3A\|GRIN3B\|HSD17B1\|NR1I2\|NR1I3\|PPARA\|SIGMAR1\|SULT2A1\|SULT2B1	protein synthesis stimulant	Details
C01640	BRD-K75748943	DG-172	PPARD	PPAR receptor inverse agonist	Details
C01662	BRD-K08252256	diclofenac	AKR1C3\|ALOX5\|ASIC1\|ASIC3\|KCNQ2\|KCNQ3\|PLA2G2A\|PPARG\|PTGS1\|PTGS2\|SCN4A	cyclooxygenase inhibitor	Details
C01767	BRD-K39965020	doconexent	FFAR1\|PTGS1\|PTGS2	PPAR receptor agonist	Details
C01850	BRD-A25182582	edaglitazone	PPARG	PPAR receptor agonist	Details
C01861	BRD-A24560335	efatutazone	PPARG	PPAR receptor agonist	Details
C01876	BRD-K03165895	elafibranor	PPARA\|PPARD	PPAR receptor agonist	Details
C01912	BRD-A11776908	enilconazole	CYP19A1\|CYP1A2\|CYP2B6\|CYP2C9\|CYP2J2\|CYP3A4\|CYP3A5\|NR1I2\|PPARA\|PTGER2	sterol demethylase inhibitor	Details
C02049	BRD-K49338325	etofibrate	PPARA	PPAR receptor agonist	Details
C02051	BRD-K49840922	etofylline-clofibrate	PPARA	platelet aggregation inhibitor	Details
C02121	BRD-K50388907	fenofibrate	MMP25\|PPARA	PPAR receptor agonist	Details
C02122	BRD-K30213273	fenofibric-acid	CLCN1\|PPARA	cytochrome P450 inhibitor	Details
C02145	BRD-K48112880	FH-535	PPARD\|PPARG	PPAR receptor antagonist; WNT signaling inhibitor	Details
C02224	BRD-K15327298	fmoc-l-leucine		PPAR receptor agonist	Details
C02293	BRD-K77345217	gallic-acid	CA1\|CA12\|CA14\|CA2\|CA4\|CA6\|CA9\|SELP	beta amyloid protein neurotoxicity inhibitor; PPAR receptor agonist	Details
C02328	BRD-K11129031	gemfibrozil	LPL\|PPARA\|SLCO1B1\|SLCO1B3\|SLCO2B1	lipoprotein lipase activator	Details
C02333	BRD-K43797669	genistein	CFTR\|ESR1\|ESR2\|ESRRA\|ESRRB\|ESRRG\|NCOA1\|NCOA2\|PPARG\|PTK2B\|TOP2A\|TRPC5	tyrosine kinase inhibitor	Details
C02362	BRD-K12219985	glipizide	ABCC8\|KCNJ10\|KCNJ11\|PPARG	sulfonylurea	Details
C02422	BRD-K98684188	GSK-0660	PPARD	PPAR receptor antagonist	Details
C02452	BRD-K03155172	GSK3787	PPARD	PPAR receptor antagonist	Details
C02475	BRD-K82983861	GW-0742	PPARD	PPAR receptor agonist	Details
C02477	BRD-A15415227	GW-1929	PPARG	PPAR receptor agonist	Details
C02485	BRD-K14880289	GW-501516	PPARA\|PPARD	PPAR receptor agonist	Details
C02490	BRD-K20828910	GW-6471	PPARA	PPAR receptor antagonist	Details
C02491	BRD-K96263742	GW-7647	PPARA	PPAR receptor agonist	Details
C02497	BRD-K93258693	GW-9662	NCOA2\|PPARG\|RXRA	PPAR receptor antagonist	Details
C02529	BRD-K15231341	hemomex-s	PPARG		Details
C02619	BRD-K14965640	ibuprofen-(s)	ASIC1\|BCL2\|CFTR\|FABP2\|PLAT\|PPARG\|PTGS1\|PTGS2\|SLC5A8\|THBD	cyclooxygenase inhibitor	Details
C02629	BRD-K24476327	icaritin	PDE5A	PPAR receptor antagonist	Details
C02642	BRD-K47192521	icosapent	ACSL3\|ACSL4\|FADS1\|FFAR1\|PPARD\|PPARG\|PTGS1\|PTGS2\|SLC8A1\|TRPV1	platelet aggregation inhibitor	Details
C02711	BRD-K57222227	indomethacin	GLO1\|PLA2G2A\|PPARA\|PPARG\|PTGDR2\|PTGR2\|PTGS1\|PTGS2\|SLC46A1	cyclooxygenase inhibitor	Details
C02943	BRD-K98372770	L-165041	PPARD	PPAR receptor agonist	Details
C03069	BRD-K08973992	linoleic-acid	FABP4\|FFAR1\|FFAR4\|HNF4A\|KCNB1\|PPARG\|TRPM8	oxidative stress inducer	Details
C03207	BRD-K26168087	magnolol	GABRA1\|PPARG	PPAR receptor agonist	Details
C03244	BRD-K24283677	ME-0328	PARP3	PPAR receptor antagonist	Details
C03313	BRD-K28849549	mesalazine	ALOX5\|CHUK\|IKBKB\|MPO\|PPARG\|PTGS1\|PTGS2	cyclooxygenase inhibitor; lipoxygenase inhibitor; prostanoid receptor antagonist	Details
C03412	BRD-A72066420	mifobate	PPARG	PPAR receptor antagonist	Details
C03434	BRD-K52959329	mitiglinide	ABCC8\|KCNJ10\|PPARG	insulin secretagogue	Details
C03631	BRD-K44353683	nateglinide	ABCC8\|KCNJ10\|KCNJ11\|PPARG	insulin secretagogue	Details
C03773	BRD-K65275554	NPC-15199	PPARG	ICAM1 antagonist	Details
C03805	BRD-K54708045	nTZDpa	PPARG	PPAR receptor agonist	Details
C03871	BRD-K66956375	oleoylethanolamide	CNR1\|GPR119\|GPR55\|PPARA	cannabinoid receptor agonist; glucose dependent insulinotropic receptor agonist; potassium channel blocker; PPAR receptor agonist	Details
C04264	BRD-A48430263	pioglitazone	PPARG\|TRPM3	insulin sensitizer; PPAR receptor agonist	Details
C04288	BRD-K01902415	pirinixic-acid	PPARA	PPAR receptor agonist	Details
C04467	BRD-K53097745	pterostilbene	PTGS2	cyclooxygenase inhibitor; PPAR receptor agonist	Details
C04571	BRD-K82846253	repaglinide	ABCC8\|KCNJ11\|PPARG	insulin secretagogue	Details
C04686	BRD-A97437073	rosiglitazone	ACSL4\|FFAR1\|PPARG\|TRPC5\|TRPM3	insulin sensitizer; PPAR receptor agonist	Details
C04786	BRD-K79878800	saroglitazar	PPARA\|PPARG	PPAR receptor agonist	Details
C05051	BRD-K62814487	SR-1664	PPARG	PPAR receptor ligand	Details
C05131	BRD-K10670311	sulfasalazine	ACAT1\|ALOX5\|CHUK\|IKBKB\|PLA2G1B\|PPARG\|PTGS1\|PTGS2\|SLC46A1\|SLC7A11\|TBXAS1	cyclooxygenase inhibitor	Details
C05136	BRD-A13946108	sulindac	AKR1B1\|MAPK3\|PPARD\|PTGDR2\|PTGS1\|PTGS2	cyclooxygenase inhibitor	Details
C05166	BRD-K48826825	S26948	PPARG	PPAR receptor agonist	Details
C05168	BRD-K31843556	T-0070907	PPARG	PPAR receptor antagonist	Details
C05303	BRD-K73999723	telmisartan	AGTR1\|PPARG	angiotensin receptor antagonist	Details
C05343	BRD-K15507868	tesaglitazar	PPARA\|PPARG	insulin sensitizer; PPAR receptor agonist	Details
C05535	BRD-K71879491	tretinoin	ALDH1A1\|ALDH1A2\|GPRC5A\|NR0B1\|NR2C2\|PPARD\|RARA\|RARB\|RARG\|RARRES1\|RORB\|RORC\|RXRB\|RXRG	retinoid receptor agonist; retinoid receptor ligand	Details
C05584	BRD-A13084692	troglitazone	ACSL4\|ESRRA\|ESRRG\|PPARG\|SERPINE1\|SLC29A1\|TRPM3	insulin sensitizer; PPAR receptor agonist	Details