CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C00001 | BRD-K89787693 | [sar9,met(o2)11]-substance-p | TACR1 | tachykinin antagonist | Details | |
| C00002 | BRD-K70329400 | A-1070722 | GSK3A|GSK3B | glycogen synthase kinase inhibitor | Details | |
| C00003 | BRD-K59060513 | A-1120 | RBP4 | retinoid receptor ligand | Details | |
| C00004 | BRD-K38019854 | A-317491 | P2RX3 | purinergic receptor antagonist | Details | |
| C00005 | BRD-A40302156 | A-33903 | Details | |||
| C00006 | BRD-K06182768 | A-366 | EHMT1|EHMT2 | histone lysine methyltransferase inhibitor | Details | |
| C00007 | BRD-K62066682 | A-412997 | DRD4 | dopamine receptor agonist | Details | |
| C00008 | BRD-K13223831 | A-438079 | P2RX7 | purinergic receptor antagonist | Details | |
| C00009 | BRD-K79743788 | A-582941 | CHRNA7 | nicotinic receptor agonist | Details | |
| C00010 | BRD-K13142315 | A-61603 | ADRA1A|ADRA1B|ADRA1D | adrenergic receptor agonist | Details | |
| C00011 | BRD-K78177893 | A-674563 | AKT1|PKIA|PRKACA | AKT inhibitor | Details | |
| C00012 | BRD-K03301001 | A-7 | calmodulin antagonist | Details | ||
| C00013 | BRD-K41918892 | A-769662 | AMPK activator | Details | ||
| C00014 | BRD-K87665527 | A-784168 | TRPV1 | transient receptor potential channel antagonist | Details | |
| C00015 | BRD-K28570407 | A-803467 | SCN10A | sodium channel blocker | Details | |
| C00016 | BRD-K76894955 | A-804598 | P2RX7 | purinergic receptor antagonist | Details | |
| C00017 | BRD-K60427831 | A-839977 | P2RX7 | purinergic receptor antagonist | Details | |
| C00018 | BRD-K33059059 | A-867744 | CHRNA3|CHRNA4|CHRNA7 | acetylcholine receptor allosteric modulator | Details | |
| C00019 | BRD-K20239555 | A-887826 | SCN10A | sodium channel blocker | Details | |
| C00020 | BRD-K81614372 | A-922500 | DGAT1 | diacylglycerol O acyltransferase inhibitor | Details | |
| C00021 | BRD-K99308908 | A-939572 | SCD | stearoyl-CoA desaturase inhibitor | Details | |
| C00022 | BRD-K70744942 | A-967079 | TRPA1 | transient receptor potential channel antagonist | Details | |
| C00023 | BRD-K68982262 | A-987306 | ADORA1|AVPR1A|CCR1|CHRM1|CHRM2|CHRM3|CHRM4|DRD3|HTR1A|HTR1B|HTR2A|HTR2B|HTR3A|TACR2 | histamine receptor antagonist | Details | |
| C00024 | BRD-K13944729 | AA-29504 | GABRA1|GABRA4|GABRB3 | GABA receptor positive allosteric modulator | Details | |
| C00025 | BRD-K17443395 | abacavir | nucleoside reverse transcriptase inhibitor | Details | ||
| C00026 | BRD-K77432251 | abafungin | sterol methyltransferase inhibitor | Details | ||
| C00027 | BRD-A25579302 | abamectin | GABBR1|GABBR2 | benzodiazepine receptor agonist | Details | |
| C00028 | BRD-K65498798 | abametapir | MMP9 | metalloproteinase inhibitor | Details | |
| C00029 | BRD-A70814879 | ABC-294640 | SPHK2 | sphingosine kinase inhibitor | Details | |
| C00030 | BRD-K33622447 | abemaciclib | CDK4|CDK6 | CDK inhibitor | Details | |
| C00031 | BRD-K50071428 | abiraterone | CYP11B1|CYP17A1 | androgen biosynthesis inhibitor | Details | |
| C00032 | BRD-K24048528 | abiraterone-acetate | CYP17A1 | androgen biosynthesis inhibitor | Details | |
| C00033 | BRD-A29844814 | ABT-202 | acetylcholine receptor agonist | Details | ||
| C00034 | BRD-K22749967 | ABT-239 | HRH1|HRH2|HRH3 | histamine receptor antagonist | Details | |
| C00035 | BRD-K97233161 | ABT-491 | PTAFR | platelet activating factor receptor antagonist | Details | |
| C00036 | BRD-K11792081 | ABT-639 | CACNA1G|CACNA1H|CACNA1I | calcium channel blocker | Details | |
| C00037 | BRD-K36021395 | ABT-702 | ADK | adenosine kinase inhibitor | Details | |
| C00038 | BRD-K37714784 | ABT-724 | DRD4 | dopamine receptor agonist | Details | |
| C00039 | BRD-K56301217 | ABT-737 | BCL2|BCL2L1|BCL2L2 | BCL inhibitor | Details | |
| C00040 | BRD-K91623615 | ABT-751 | TUBB | tubulin polymerization inhibitor | Details | |
| C00041 | BRD-K53788420 | AC-186 | ESR2 | estrogen receptor agonist | Details | |
| C00042 | BRD-K31144453 | AC-261066 | RARB | retinoid receptor agonist | Details | |
| C00043 | BRD-K81548480 | AC-264613 | F2RL1 | PAR agonist | Details | |
| C00044 | BRD-A27911617 | AC-55541 | PARP2 | PARP inhibitor | Details | |
| C00045 | BRD-K93176058 | AC-55649 | RARA|RARB | retinoid receptor agonist | Details | |
| C00046 | BRD-K15819326 | AC-710 | CSF1R|FLT3|KIT|PDGFRA|PDGFRB | PDGFR tyrosine kinase receptor inhibitor | Details | |
| C00047 | BRD-A49544621 | AC-7954-(+/-) | UTS2R | urotensin receptor agonist | Details | |
| C00048 | BRD-K53448858 | acadesine | AMPK activator | Details | ||
| C00049 | BRD-K64034691 | acalabrutinib | BTK | Bruton's tyrosine kinase (BTK) inhibitor | Details | |
| C00050 | BRD-K92517771 | acalisib | PIK3CB|PIK3CD | PI3K inhibitor | Details | |
| C00051 | BRD-K26262077 | acamprosate | GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B|GRM5 | glutamate receptor antagonist | Details | |
| C00052 | BRD-K44276885 | acarbose | AMY2A|GAA|MGAM|SI | glucosidase inhibitor | Details | |
| C00053 | BRD-K68633617 | ACDPP | GRM5 | glutamate receptor antagonist | Details | |
| C00054 | BRD-A29260609 | acebutolol | ADRB1|ADRB2 | adrenergic receptor antagonist | Details | |
| C00055 | BRD-K07753030 | acecainide | SCN5A | polarization inhibitor | Details | |
| C00056 | BRD-A32673558 | aceclidine | CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 | acetylcholine receptor agonist | Details | |
| C00057 | BRD-K68538666 | aceclofenac | PTGS2 | prostanoid receptor antagonist | Details | |
| C00058 | BRD-K97417064 | acedapsone | Details | |||
| C00059 | BRD-K47195926 | acedoben | Details | |||
| C00060 | BRD-K44004064 | acefylline | ADORA1 | adenosine receptor agonist | Details | |
| C00061 | BRD-K13619941 | aceglutamide | Details | |||
| C00062 | BRD-K67563174 | acemetacin | PTGS1|PTGS2 | cyclooxygenase inhibitor | Details | |
| C00063 | BRD-K36262466 | aceneuramic-acid | AZGP1|CES1|MBL2|REG1A|SELE|SELP|SIGLEC1 | Details | ||
| C00064 | BRD-A65051990 | acenocoumarol | VKORC1 | vitamin K antagonist | Details | |
| C00065 | BRD-K37814297 | acepromazine | ADRA1A|ADRA1B|DRD1|DRD2|HTR1A|HTR2A | dopamine receptor antagonist | Details | |
| C00066 | BRD-K50850824 | acesulfame-potassium | Details | |||
| C00067 | BRD-K11094367 | acetanilide | hydrogen peroxide decomposition inhibitor | Details | ||
| C00068 | BRD-K99048103 | acetarsol | Details | |||
| C00069 | BRD-K43457670 | acetazolamide | AQP1|CA1|CA12|CA14|CA2|CA3|CA4|CA7 | carbonic anhydrase inhibitor | Details | |
| C00070 | BRD-K52960356 | acetohexamide | ABCC8|KCNJ1|KCNJ10|KCNJ11 | ATP channel blocker | Details | |
| C00071 | BRD-K21615095 | acetohydroxamic-acid | MMP12 | urease inhibitor | Details | |
| C00072 | BRD-K42938903 | acetophenazine | DRD1|DRD2 | dopamine receptor antagonist | Details | |
| C00073 | BRD-K46416130 | acetriazoic-acid | Details | |||
| C00074 | BRD-K79437791 | acetyl-farnesyl-cysteine | PPARG | methyltransferase inhibitor | Details | |
| C00075 | BRD-K27406233 | acetyl-l-leucine | Details | |||
| C00076 | BRD-A44696962 | acetyl-11-keto-beta-boswellic-acid | HSD11B1|HSD11B2 | lipoxygenase inhibitor | Details | |
| C00077 | BRD-K82381502 | acetylcholine | ACHE|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|CHRNA2 | acetylcholine receptor agonist | Details | |
| C00078 | BRD-K59058747 | acetylcysteine | ACY1|CHUK|GRIN1|GRIN2A|GRIN2B|GRIN2D|GRIN3A|GSS|IKBKB|RELA|SLC7A11 | mucolytic agent | Details | |
| C00079 | BRD-K46585355 | acetylsalicylsalicylic-acid | cyclooxygenase inhibitor | Details | ||
| C00080 | BRD-K72215350 | acexamic-acid | GAST | 5 alpha reductase inhibitor | Details | |
| C00081 | BRD-A29520968 | acifran | HCAR2|HCAR3 | cholesterol inhibitor | Details | |
| C00082 | BRD-K63736853 | acipimox | HCAR2 | cholesterol inhibitor | Details | |
| C00083 | BRD-K74236708 | acitazanolast | mediator release inhibitor | Details | ||
| C00084 | BRD-K62012036 | acitretin | RARA|RARB|RARG|RBP1|RXRA|RXRB|RXRG|STAT3 | retinoid receptor agonist | Details | |
| C00085 | BRD-K13050541 | acivicin | CTPS1 | gamma glutamyltransferase Inhibitors | Details | |
| C00086 | BRD-A80805100 | aclarubicin | TOP1|TOP2A | topoisomerase inhibitor | Details | |
| C00087 | BRD-K74363950 | aclidinium | CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 | acetylcholine receptor antagonist | Details | |
| C00088 | BRD-K66465025 | ACPC | glutamate receptor antagonist | Details | ||
| C00089 | BRD-M87138257 | acriflavine | HIF1A | hypoxia inducible factor inhibitor | Details | |
| C00090 | BRD-K97874492 | acriflavinium | HIF1A | hypoxia inducible factor inhibitor | Details | |
| C00091 | BRD-M49658242 | acrisorcin | other antifungal | Details | ||
| C00092 | BRD-K50163129 | acrivastine | HRH1 | histamine receptor antagonist | Details | |
| C00093 | BRD-M00184283 | acrylate | mucus protecting agent | Details | ||
| C00094 | BRD-K34843150 | ACT-132577 | EDNRA|EDNRB | endothelin receptor antagonist | Details | |
| C00095 | BRD-K19781342 | ACT-462206 | HCRTR1|HCRTR2 | orexin receptor antagonist | Details | |
| C00096 | BRD-K33483813 | actarit | interleukin receptor agonist | Details | ||
| C00097 | BRD-K35936936 | ACTB-1003 | KDR|TEK | FGFR inhibitor; VEGFR inhibitor | Details | |
| C00098 | BRD-K16547679 | actinomycin-d | RNA polymerase inhibitor | Details | ||
| C00099 | BRD-K08837089 | actinoquinol | Details | |||
| C00100 | BRD-K82928847 | ACY-1215 | HDAC1|HDAC2|HDAC3|HDAC6|HDAC8 | HDAC inhibitor | Details |