CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C02601 | BRD-A51571244 | hypoestoxide | IKBKB|IL1B|TNF | IKK inhibitor | Details | |
| C02602 | BRD-K03739921 | hypoxanthine | PNP | PARP inhibitor | Details | |
| C02603 | BRD-K26439554 | H2L-5765834 | LPAR1|LPAR3 | lysophosphatidic acid receptor antagonist | Details | |
| C02604 | BRD-K08109215 | I-BET-762 | BRD2|BRD3|BRD4 | bromodomain inhibitor | Details | |
| C02605 | BRD-K36363294 | I-BET151 | BRD2|BRD3|BRD4 | bromodomain inhibitor | Details | |
| C02606 | BRD-K04972057 | I-BRD9 | BRD9 | bromodomain inhibitor | Details | |
| C02607 | BRD-K14762862 | I-BZA | Details | |||
| C02608 | BRD-K71698503 | I-BZA2 | Details | |||
| C02609 | BRD-K57090026 | I-CBP-112 | CREBBP|EP300 | bromodomain inhibitor | Details | |
| C02610 | BRD-K31135544 | IB-MECA | ADORA1|ADORA2A|ADORA2B|ADORA3 | adenosine receptor agonist | Details | |
| C02611 | BRD-K08681769 | ibandronate | FDPS | bone resorption inhibitor | Details | |
| C02612 | BRD-K15196155 | IBC-293 | HCAR3 | hydroxycarboxylic acid receptor agonist | Details | |
| C02613 | BRD-K94979336 | IBMX | ADORA1|PDE2A|PDE3B|PDE4D|PDE5A|PDE6G|PDE7A|PDE8A|PDE9A | phosphodiesterase inhibitor | Details | |
| C02614 | BRD-A04628621 | ibotenic-acid | GRIN1 | glutamate receptor agonist | Details | |
| C02615 | BRD-K62490786 | ibrolipim | LPL | lipoprotein lipase activator | Details | |
| C02616 | BRD-K70301465 | ibrutinib | BLK|BMX|BTK | Bruton's tyrosine kinase (BTK) inhibitor | Details | |
| C02617 | BRD-K16444452 | ibudilast | IL1B|IL6|PDE3A|PDE4A|PDE4B|PDE4C|PDE4D|PDE5A | leukotriene receptor antagonist; phosphodiesterase inhibitor | Details | |
| C02618 | BRD-A17655518 | ibuprofen | PTGS1|PTGS2 | cyclooxygenase inhibitor | Details | |
| C02619 | BRD-K14965640 | ibuprofen-(s) | ASIC1|BCL2|CFTR|FABP2|PLAT|PPARG|PTGS1|PTGS2|SLC5A8|THBD | cyclooxygenase inhibitor | Details | |
| C02620 | BRD-M64062803 | ibuprofen-lysine | PTGS1|PTGS2 | cyclooxygenase inhibitor | Details | |
| C02621 | BRD-A75224450 | ibuprofen-piconol | PTGS1|PTGS2 | cyclooxygenase inhibitor | Details | |
| C02622 | BRD-A40940854 | ibuproxam | ALOX5 | cyclooxygenase inhibitor; prostaglandin inhibitor | Details | |
| C02623 | BRD-K44771174 | ibutamoren | GHR|GHSR | growth hormone secretagogue receptor agonist | Details | |
| C02624 | BRD-A74391928 | ibutilide | CACNA1C|CACNA2D1|CACNB1|CACNG1|KCNH2|KCNH6|KCNH7|KCNJ11|KCNK1|KCNK6 | potassium channel blocker | Details | |
| C02625 | BRD-K59839632 | ICA-069673 | KCNQ2|KCNQ3 | voltage-gated potassium channel activator | Details | |
| C02626 | BRD-K71686520 | ICA-110381 | KCNQ2 | voltage-gated potassium channel activator | Details | |
| C02627 | BRD-K03149601 | ICA-121431 | SCN1A|SCN3A | sodium channel blocker | Details | |
| C02628 | BRD-K65639003 | icariin | PDE5A | phosphodiesterase inhibitor | Details | |
| C02629 | BRD-K24476327 | icaritin | PDE5A | PPAR receptor antagonist | Details | |
| C02630 | BRD-K63772874 | icatibant-acetate | ANPEP|BDKRB2 | bradykinin receptor antagonist | Details | |
| C02631 | BRD-K94455792 | ICG-001 | CTNNB1 | beta-catenin inhibitor | Details | |
| C02632 | BRD-K74603273 | ICI-118,551 | ADRB2|ADRB3 | adrenergic receptor antagonist | Details | |
| C02633 | BRD-K11071038 | ICI-162846 | HRH2 | histamine receptor antagonist | Details | |
| C02634 | BRD-K29133151 | ICI-185,282 | thromboxane receptor antagonist | Details | ||
| C02635 | BRD-K59433843 | ICI-192605 | TBXA2R | thromboxane receptor antagonist | Details | |
| C02636 | BRD-K73290745 | ICI-199441 | CYP2D6|OPRD1|OPRK1|OPRM1|UTS2R | opioid receptor agonist | Details | |
| C02637 | BRD-K52487250 | ICI-215,001 | ADRB3 | adrenergic receptor agonist | Details | |
| C02638 | BRD-K52219182 | ICI-63197 | phosphodiesterase inhibitor | Details | ||
| C02639 | BRD-A03359064 | ICI-89406 | ADRB1|ADRB2 | adrenergic receptor antagonist | Details | |
| C02640 | BRD-K48869804 | icilin | TRPA1|TRPM8 | TRPV agonist | Details | |
| C02641 | BRD-K41234004 | icomucret | LTB4R2 | mucin production enhancer | Details | |
| C02642 | BRD-K47192521 | icosapent | ACSL3|ACSL4|FADS1|FFAR1|PPARD|PPARG|PTGS1|PTGS2|SLC8A1|TRPV1 | platelet aggregation inhibitor | Details | |
| C02643 | BRD-K31698212 | icotinib | EGFR | EGFR inhibitor | Details | |
| C02644 | BRD-K18634484 | iCRT-14 | CTNNB1|TCF4 | WNT signaling inhibitor; beta catenin inhibitor | Details | |
| C02645 | BRD-K09638361 | IC261 | CSNK1A1|CSNK1D|CSNK1E|CSNK1G2 | casein kinase inhibitor | Details | |
| C02646 | BRD-K90305467 | ID-1101 | INS | insulin sensitizer | Details | |
| C02647 | BRD-K39166528 | ID-8 | Details | |||
| C02648 | BRD-K79102359 | idalopirdine | HTR6 | serotonin receptor antagonist | Details | |
| C02649 | BRD-K69650333 | idarubicin | TOP2A | topoisomerase inhibitor | Details | |
| C02650 | BRD-K62627508 | idasanutlin | MDM2|TP53 | MDM inhibitor | Details | |
| C02651 | BRD-A18696154 | idazoxan | ADRA2A | adrenergic receptor antagonist | Details | |
| C02652 | BRD-K70759443 | idazoxane | ADRA2A|ADRA2B|ADRA2C | adrenergic receptor antagonist | Details | |
| C02653 | BRD-K37516142 | idebenone | calcium channel modulator | Details | ||
| C02654 | BRD-K60866521 | idelalisib | PIK3CA|PIK3CB|PIK3CD|PIK3CG | PI3K inhibitor | Details | |
| C02655 | BRD-K76634210 | idoxuridine | DNA directed DNA polymerase inhibitor | Details | ||
| C02656 | BRD-K22356203 | IDO5L | IDO1 | indoleamine 2,3-dioxygenase inhibitor | Details | |
| C02657 | BRD-A14344385 | IDRA-21 | GRIA1|GRIA2|GRIA3|GRIA4 | glutamate receptor positive allosteric modulator | Details | |
| C02658 | BRD-A57877027 | idramantone | Details | |||
| C02659 | BRD-K74671368 | idronoxil | ENOX2|SPHK1 | XIAP inhibitor | Details | |
| C02660 | BRD-K13829090 | IEM1460 | GRIA2 | glutamate receptor antagonist | Details | |
| C02661 | BRD-K80060353 | IEM1754 | GRIA1 | glutamate receptor antagonist | Details | |
| C02662 | BRD-A24191444 | ifenprodil | GRIN1|GRIN2B | adrenergic receptor antagonist; glutamate receptor antagonist | Details | |
| C02663 | BRD-A67097164 | ifosfamide | CYP2A6|CYP2B6|CYP2C18|CYP2C19|CYP2C8|CYP2C9|CYP3A4|CYP3A5|CYP3A7|PTGS1 | DNA alkylating agent | Details | |
| C02664 | BRD-A48376327 | igmesine | SIGMAR1 | sigma receptor agonist | Details | |
| C02665 | BRD-K15426076 | iguratimod | PTGS2 | cyclooxygenase inhibitor; NFkB pathway inhibitor | Details | |
| C02666 | BRD-K14618467 | IKK-16 | IKBKB | IKK inhibitor | Details | |
| C02667 | BRD-K26373640 | IKK-2-inhibitor | IKBKB | IKK inhibitor; SYK inhibitor | Details | |
| C02668 | BRD-K74305673 | IKK-2-inhibitor-V | IKBKB | IKK inhibitor; NFkB pathway inhibitor | Details | |
| C02669 | BRD-K43873574 | ilepcimide | anticonvulsant | Details | ||
| C02670 | BRD-K51662849 | ilomastat | ACAN|ADAM28|MMP1|MMP12|MMP13|MMP14|MMP2|MMP3|MMP8|MMP9 | matrix metalloprotease inhibitor | Details | |
| C02671 | BRD-K48722833 | iloperidone | ADRA1A|ADRA2C|DRD1|DRD2|DRD3|DRD4|HRH1|HTR1A|HTR2A|HTR6|HTR7 | dopamine receptor antagonist; serotonin receptor antagonist | Details | |
| C02672 | BRD-A45664787 | iloprost | PDE4A|PDE4B|PDE4C|PDE4D|PLAT|PTGDR|PTGER1|PTGER2|PTGER3|PTGER4|PTGFR|PTGIR|TBXA2R | platelet aggregation inhibitor; prostanoid receptor agonist | Details | |
| C02673 | BRD-K92723993 | imatinib | ABL1|CSF1R|DDR1|KIT|NTRK1|PDGFRA|PDGFRB|RET | Bcr-Abl kinase inhibitor; KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor | Details | |
| C02674 | BRD-K55822903 | imeglimin | gluconeogenesis inhibitor | Details | ||
| C02675 | BRD-K33183200 | imetit | HRH3|HRH4 | histamine receptor agonist | Details | |
| C02676 | BRD-A78195072 | imexon | RRM1|RRM2 | apoptosis stimulant; ribonucleotide reductase inhibitor | Details | |
| C02677 | BRD-K76609936 | imidacloprid | CHRFAM7A | acetylcholine receptor antagonist | Details | |
| C02678 | BRD-K29626940 | imidafenacin | CHRM1|CHRM3 | acetylcholine receptor antagonist | Details | |
| C02679 | BRD-K34332569 | imidapril | ACE | angiotensin converting enzyme inhibitor | Details | |
| C02680 | BRD-A65444648 | imidurea | other antibiotic | Details | ||
| C02681 | BRD-A10903566 | imiloxan | ADRA2A|ADRA2B | adrenergic receptor antagonist | Details | |
| C02682 | BRD-K23200955 | imipenem | bacterial cell wall synthesis inhibitor | Details | ||
| C02683 | BRD-K38436528 | imipramine | ADRA1A|ADRA1B|ADRA1D|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD5|HRH1|HTR1A|HTR2A|HTR2C|HTR6|HTR7|KCND2|KCND3|KCNH1|KCNH2|SLC6A2|SLC6A3|SLC6A4 | norepinephrine reputake inhibitor; serotonin reuptake inhibitor | Details | |
| C02684 | BRD-K26657438 | imiquimod | TLR7|TLR8 | interferon inducer; toll-like receptor agonist | Details | |
| C02685 | BRD-K25906698 | immepip | HRH3|HRH4 | histamine receptor agonist | Details | |
| C02686 | BRD-K49519092 | immethridine | HRH3 | histamine receptor agonist | Details | |
| C02687 | BRD-K20049318 | impentamine | HRH3 | histamine receptor antagonist | Details | |
| C02688 | BRD-K00926464 | IMREG-1 | Details | |||
| C02689 | BRD-K81016934 | INC-280 | MET | c-Met inhibitor | Details | |
| C02690 | BRD-K33308633 | INCA-6 | NFATC1 | calcineurin inhibitor | Details | |
| C02691 | BRD-K28059174 | INCB-003284 | CC chemokine receptor antagonist | Details | ||
| C02692 | BRD-K79450420 | INCB-024360 | IDO1 | indoleamine 2,3-dioxygenase inhibitor | Details | |
| C02693 | BRD-K67628093 | INCB-3284 | CCR2 | CC chemokine receptor antagonist | Details | |
| C02694 | BRD-K89208535 | indacaterol | ADRB1|ADRB2 | adrenergic receptor agonist | Details | |
| C02695 | BRD-K64973364 | indalpine | SLC6A4 | selective serotonin reuptake inhibitor (SSRI) | Details | |
| C02696 | BRD-A95869247 | indapamide | KCNE1|KCNQ1|SLC12A3 | thiazide diuretic | Details | |
| C02697 | BRD-K01649396 | indatraline | MAOA|MAOB | norepinephrine transporter inhibitor | Details | |
| C02698 | BRD-A59747053 | indeloxazine | norepinephrine reuptake inhibitor; serotonin reuptake inhibitor | Details | ||
| C02699 | BRD-K74057757 | indibulin | tubulin polymerization inhibitor | Details | ||
| C02700 | BRD-K33226500 | indinavir | CYP3A4|CYP3A5|CYP3A7 | HIV protease inhibitor | Details |