CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C05401 | BRD-K97309399 | thiothixene | DRD1|DRD2|HRH1|HTR2A | dopamine receptor antagonist | Details | |
| C05402 | BRD-K29254801 | thiram | JAK2 | Details | ||
| C05403 | BRD-K13387373 | thonzonium | ATPase inhibitor | Details | ||
| C05404 | BRD-K88405679 | thonzylamine | antihistamine | Details | ||
| C05405 | BRD-M01344114 | threo-2-methylisocitrate-(DL) | isocitrate lyase substrate | Details | ||
| C05406 | BRD-K17458574 | thymol | TRPA1 | GABA receptor positive allosteric modulator | Details | |
| C05407 | BRD-K36617478 | thymol-iodide | Details | |||
| C05408 | BRD-K66401437 | THZ1 | CDK7 | CDK inhibitor | Details | |
| C05409 | BRD-K02135007 | THZ1-R | CDK7 | CDK inhibitor | Details | |
| C05410 | BRD-K95902121 | THZ2 | CDK7 | CDK inhibitor | Details | |
| C05411 | BRD-K01054709 | TH588 | NUDT1 | MTH1 inhibitor | Details | |
| C05412 | BRD-K77695569 | tiabendazole | angiogenesis inhibitor | Details | ||
| C05413 | BRD-K60160658 | tiagabine | SLC6A1 | GABA uptake inhibitor | Details | |
| C05414 | BRD-A53077924 | tianeptine | OPRD1|OPRK1|OPRM1 | selective serotonin reuptake enhancer (SSRE) | Details | |
| C05415 | BRD-K57432881 | tiapride | DRD2|DRD3 | dopamine receptor antagonist | Details | |
| C05416 | BRD-A72988804 | tiaprofenic-acid | PTGS1|PTGS2 | cyclooxygenase inhibitor | Details | |
| C05417 | BRD-K27293958 | tiaramide | anti-inflammatory agent | Details | ||
| C05418 | BRD-A82522119 | tibolone | ESR1 | androgen receptor agonist; estrogen receptor agonist; progesterone receptor agonist | Details | |
| C05419 | BRD-K44974079 | ticagrelor | P2RY12 | purinergic receptor antagonist | Details | |
| C05420 | BRD-K29229654 | ticarcillin | lactamase inhibitor | Details | ||
| C05421 | BRD-K00603606 | ticlopidine | P2RY12 | purinergic receptor antagonist | Details | |
| C05422 | BRD-K01115818 | TIC10 | AKT1|MAPK1 | AKT inhibitor; TRAIL modulator | Details | |
| C05423 | BRD-K81330143 | tideglusib | GSK3B | glycogen synthase kinase inhibitor | Details | |
| C05424 | BRD-K34098590 | tienilic-acid | CYP2C9|SLC12A1 | sodium/potassium/chloride transporter inhibitor; cytochrome P450 inhibitor | Details | |
| C05425 | BRD-A92800748 | tie2-kinase-inhibitor | KDR|MAPK14 | TIE tyrosine kinase inhibitor | Details | |
| C05426 | BRD-K20568871 | tifenazoxide | ABCC8|KCNJ11 | ATP-sensitive potassium channel agonist | Details | |
| C05427 | BRD-A34462049 | tigecycline | bacterial 30S ribosomal subunit inhibitor | Details | ||
| C05428 | BRD-A30582499 | tiletamine | glutamate receptor antagonist | Details | ||
| C05429 | BRD-K26634012 | tilmicosin | bacterial 50S ribosomal subunit inhibitor | Details | ||
| C05430 | BRD-K34568562 | tilorone | interferon inducer | Details | ||
| C05431 | BRD-K10845183 | tiludronate | ATP6V1A|MMP2|PTPN1 | bone resorption inhibitor; osteoclast inhibitor | Details | |
| C05432 | BRD-A64406146 | timofibrate | LPL | cholesterol inhibitor; lipase clearing factor inhibitor | Details | |
| C05433 | BRD-K30421593 | timolol | ADRB1|ADRB2 | adrenergic receptor antagonist | Details | |
| C05434 | BRD-A38592941 | timonacic | ANXA5 | antioxidant | Details | |
| C05435 | BRD-K89125793 | tinidazole | antiprotozoal agent | Details | ||
| C05436 | BRD-A33084557 | tioconazole | CYP51A1 | sterol demethylase inhibitor | Details | |
| C05437 | BRD-K75649340 | tioguanine | purine antagonist | Details | ||
| C05438 | BRD-A85295731 | tiopronin | chelating agent; reducing agent | Details | ||
| C05439 | BRD-K15071410 | tiotidine | HRH2 | histamine receptor antagonist | Details | |
| C05440 | BRD-K62782754 | tiotropium | CHRM1|CHRM2|CHRM3 | acetylcholine receptor antagonist | Details | |
| C05441 | BRD-K41876534 | tioxolone | CA2 | carbonic anhydrase inhibitor | Details | |
| C05442 | BRD-K62965247 | tipifarnib | FNTA|FNTB | farnesyltransferase inhibitor | Details | |
| C05443 | BRD-K11973162 | tipiracil | TYMP | thymidine phosphorylase inhibitor | Details | |
| C05444 | BRD-K30882994 | tiplaxtinin | SERPINE1 | plasminogen activator inhibitor | Details | |
| C05445 | BRD-A10039652 | tipranavir | HIV protease inhibitor | Details | ||
| C05446 | BRD-A73566563 | tiprenolol | ADRB1|ADRB2|ADRB3 | adrenergic receptor antagonist | Details | |
| C05447 | BRD-K77552740 | tiquizium | acetylcholine receptor antagonist | Details | ||
| C05448 | BRD-K75250001 | tiracizine | SCN5A | sodium channel blocker | Details | |
| C05449 | BRD-K92968657 | tirapazamine | DNA inhibitor | Details | ||
| C05450 | BRD-K51087630 | tirasemtiv | troponin activator | Details | ||
| C05451 | BRD-K61236135 | tiratricol | THRA|THRB | thyroid hormone stimulant | Details | |
| C05452 | BRD-K37872686 | tirofiban | ITGA2B|ITGB3 | platelet aggregation inhibitor; structural glycoprotein antagonist | Details | |
| C05453 | BRD-K60284353 | titanocene-dichloride | apoptosis stimulant | Details | ||
| C05454 | BRD-K33379087 | tivantinib | MET | tyrosine kinase inhibitor | Details | |
| C05455 | BRD-K53414658 | tivozanib | FLT1|FLT4|KDR|KIT|PDGFRA|PDGFRB | VEGFR inhibitor | Details | |
| C05456 | BRD-K06335600 | tizanidine | ADRA2A|ADRA2B|ADRA2C|NISCH | adrenergic receptor agonist | Details | |
| C05457 | BRD-K66097663 | TMC-353121 | RSV fusion inhibitor | Details | ||
| C05458 | BRD-K49659468 | TMC647055 | RNA polymerase inhibitor | Details | ||
| C05459 | BRD-K24527118 | TMN-355 | PPIA | cyclophilin inhibitor | Details | |
| C05460 | BRD-K49119234 | TMPH | Details | |||
| C05461 | BRD-K96233303 | TMS | Details | |||
| C05462 | BRD-K53597484 | TNP-470 | methionine aminopeptidase inhibitor | Details | ||
| C05463 | BRD-K05619559 | tobramycin | bacterial 30S ribosomal subunit inhibitor | Details | ||
| C05464 | BRD-A92670106 | tocainide | SCN5A | sodium channel blocker | Details | |
| C05465 | BRD-K62040061 | toceranib | FLT1|FLT3|KDR|PDGFRA|PDGFRB | protein tyrosine kinase inhibitor | Details | |
| C05466 | BRD-A39830855 | tocofersolan | antioxidant | Details | ||
| C05467 | BRD-K68553471 | todralazine | antihypertensive agent | Details | ||
| C05468 | BRD-K31283835 | tofacitinib | JAK1|JAK2|JAK3|TYK2 | JAK inhibitor | Details | |
| C05469 | BRD-K94830213 | tofisopam | CYP3A4|PDE10A|PDE2A|PDE3A|PDE4A | phosphodiesterase inhibitor; cytochrome P450 inhibitor | Details | |
| C05470 | BRD-K96344439 | tofogliflozin | GCK | sodium/glucose cotransporter inhibitor | Details | |
| C05471 | BRD-A60498477 | tolamolol | ADRB1|ADRB2|ADRB3 | adrenergic receptor antagonist | Details | |
| C05472 | BRD-K32164935 | tolazamide | ABCC8|KCNJ1|KCNJ10|KCNJ11 | ATP channel blocker | Details | |
| C05473 | BRD-K46211610 | tolazoline | ADRA1A|ADRA2A|ADRA2B|ADRA2C|HRH1|HRH2 | adrenergic receptor antagonist | Details | |
| C05474 | BRD-K85119730 | tolbutamide | ABCC8|KCNJ1|KCNJ11|KCNJ8 | ATP channel blocker | Details | |
| C05475 | BRD-K10852020 | tolcapone | COMT | catechol O methyltransferase inhibitor | Details | |
| C05476 | BRD-K50133271 | tolfenamic-acid | cyclooxygenase inhibitor; prostanoid receptor antagonist | Details | ||
| C05477 | BRD-K41772907 | tolimidone | LYN|SRC | src activator | Details | |
| C05478 | BRD-K82562631 | tolmetin | PTGS1|PTGS2 | cyclooxygenase inhibitor | Details | |
| C05479 | BRD-K44273375 | tolnaftate | fungal squalene epoxidase inhibitor | Details | ||
| C05480 | BRD-K82687598 | tolonidine | ADRA2A | adrenergic receptor antagonist | Details | |
| C05481 | BRD-K94882685 | tolonium | Details | |||
| C05482 | BRD-A67182178 | toloxatone | MAOA|MAOB | monoamine oxidase inhibitor | Details | |
| C05483 | BRD-A27732521 | tolperisone | CYP2C19|CYP2D6 | voltage-gated sodium channel blocker | Details | |
| C05484 | BRD-K85693895 | tolrestat | AKR1A1|AKR1B1|AKR1B10 | aldose reductase inhibitor | Details | |
| C05485 | BRD-K54316499 | tolterodine | CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 | acetylcholine receptor antagonist | Details | |
| C05486 | BRD-K64514229 | toltrazuril | antiprotozoal agent | Details | ||
| C05487 | BRD-A82035391 | tolvaptan | AVPR1A|AVPR2 | vasopressin receptor antagonist | Details | |
| C05488 | BRD-K74765201 | tomelukast | CYSLTR1 | leukotriene receptor antagonist | Details | |
| C05489 | BRD-K36970462 | tonabersat | gap junction modulator; nitric oxide production inhibitor | Details | ||
| C05490 | BRD-K29653726 | topiramate | CA1|CA12|CA2|CA4|CA7|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GRIA1|GRIA2|GRIA3|GRIA4|GRIK1|GRIK2|GRIK3|GRIK4|GRIK5|SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A | carbonic anhydrase inhibitor; glutamate receptor antagonist; kainate receptor antagonist | Details | |
| C05491 | BRD-K77561571 | topiroxostat | XDH | xanthine oxidase inhibitor | Details | |
| C05492 | BRD-K55696337 | topotecan | TOP1|TOP1MT | topoisomerase inhibitor | Details | |
| C05493 | BRD-K30480208 | torasemide | SLC12A1 | electrolyte reabsorption inhibitor; thromboxane receptor antagonist | Details | |
| C05494 | BRD-K55675242 | torcetrapib | CETP | cholesteryl ester transfer protein inhibitor | Details | |
| C05495 | BRD-K91822704 | torcitabine | DCK|TK2 | DNA polymerase inhibitor | Details | |
| C05496 | BRD-K51350053 | toremifene | ESR1 | estrogen receptor antagonist; selective estrogen receptor modulator (SERM) | Details | |
| C05497 | BRD-K40175214 | torin-1 | MTOR | mTOR inhibitor | Details | |
| C05498 | BRD-K68174511 | torin-2 | MTOR | mTOR inhibitor | Details | |
| C05499 | BRD-K92241597 | tosedostat | ANPEP|LAP3|NPEPPS | peptidase inhibitor | Details | |
| C05500 | BRD-A41450521 | tosufloxacin | bacterial DNA gyrase inhibitor | Details |