CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

CMap Candidates

CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.

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Associated NAFLD Targets:

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6125 records.

CMap ID	Pert ID	Compound Name	Targets	MoA
C00401	BRD-K42325600	AR-C155858	SLC16A1\|SLC16A7	monocarboxylate transporter inhibitor	Details
C00402	BRD-K90497590	AR-12	PDPK1	phosphoinositide dependent kinase inhibitor	Details
C00403	BRD-K13167095	AR-42	HDAC1	HDAC inhibitor	Details
C00404	BRD-K03070961	arachidonic-acid	CLCN2\|KCNJ4\|KCNK10\|KCNK18\|KCNK2\|PRKCZ\|PTGS1\|TRPC6\|TRPM2	cytochrome P450 inhibitor	Details
C00405	BRD-K73881242	arbidol	CYP3A4	cytochrome P450 inhibitor	Details
C00406	BRD-K08037784	arbutin	TYR	melanin inhibitor	Details
C00407	BRD-K93188295	ARC-239	ADRA2A\|ADRA2B\|ADRA2C	adrenergic receptor antagonist	Details
C00408	BRD-K53523901	arctigenin	CHUK\|MAP2K1	MEK inhibitor	Details
C00409	BRD-K72726508	arcyriaflavin-a	CCND1\|CDK4	CDK inhibitor	Details
C00410	BRD-A83644949	ardeparin	SERPINC1\|SERPIND1	thrombin inhibitor	Details
C00411	BRD-K63792901	arecaidine-but-2-ynyl-ester	CHRM2	acetylcholine receptor agonist	Details
C00412	BRD-K23922020	arecaidine-propargyl-ester	CHRM1\|CHRM2\|CHRM3\|CHRM4	acetylcholine receptor agonist	Details
C00413	BRD-K88646909	arecoline	CHRM1\|CHRM2\|CHRM3\|CHRM4	acetylcholine receptor agonist	Details
C00414	BRD-A48261811	argatroban	F2	thrombin inhibitor	Details
C00415	BRD-K62734952	arglabin	FNTA\|NFKB1	farnesyltransferase inhibitor	Details
C00416	BRD-K70358946	aripiprazole	ADRA1A\|ADRA1B\|ADRA2A\|ADRA2B\|ADRA2C\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD1\|DRD2\|DRD3\|DRD4\|DRD5\|HRH1\|HTR1A\|HTR1B\|HTR1D\|HTR1E\|HTR2A\|HTR2C\|HTR3A\|HTR6\|HTR7	serotonin receptor agonist; serotonin receptor antagonist	Details
C00417	BRD-K87278688	armodafinil	SLC6A3	adrenergic receptor agonist	Details
C00418	BRD-K33852358	arofylline	PDE4A	phosphodiesterase inhibitor	Details
C00419	BRD-A28044053	arotinolol	ADRB3	adrenergic receptor antagonist	Details
C00420	BRD-K60171656	ARQ-092	AKT2	AKT inhibitor	Details
C00421	BRD-K43436647	ARQ-621	KIF11	kinesin-like spindle protein inhibitor	Details
C00422	BRD-K46386702	ARRY-334543	ERBB2	EGFR inhibitor	Details
C00423	BRD-K24179883	arsanilic-acid	LYZ		Details
C00424	BRD-K47190141	arsenic-trioxide	AKT1\|CCND1\|IKBKB\|JUN\|MAPK1\|MAPK3\|TXNRD1	apoptosis stimulant	Details
C00425	BRD-K39621635	artemether	ATP1A1	antimalarial agent	Details
C00426	BRD-K13112821	artemisinin	CYP2B6	DNA synthesis inhibitor	Details
C00427	BRD-K96006160	artemotil			Details
C00428	BRD-K54634444	artesunate		DNA synthesis inhibitor	Details
C00429	BRD-A70514680	articaine		local anesthetic	Details
C00430	BRD-K49223707	arundic-acid	PTGS2\|S100B	astrocyte modulating agent	Details
C00431	BRD-A00047421	ARV-825	BRD4	bromodomain inhibitor	Details
C00432	BRD-K07656463	AS-1269574	GPR119	glucose dependent insulinotropic receptor agonist	Details
C00433	BRD-K27051047	AS-1892802	ROCK1	rho associated kinase inhibitor	Details
C00434	BRD-K61936403	AS-1949490	INPP5D	SHIP2 phosphatase inhibitor	Details
C00435	BRD-K75254015	AS-2034178	FFAR1	free fatty acid receptor agonist	Details
C00436	BRD-K73565918	AS-2444697	IRAK4	interleukin inhibitor	Details
C00437	BRD-K14988953	AS-252424	PIK3CG	PI3K inhibitor	Details
C00438	BRD-K63915849	AS-604850	PIK3CA\|PIK3CG	PI3K inhibitor	Details
C00439	BRD-K89014967	AS-703026	MAP2K1\|MAP2K2	MEK inhibitor	Details
C00440	BRD-K62427771	AS-77	KCNA3\|KCNA5\|KCNN4	potassium channel blocker	Details
C00441	BRD-K27938825	ASA-404		angiogenesis inhibitor	Details
C00442	BRD-K88219015	asaraldehyde	PTGS2	cyclooxygenase inhibitor	Details
C00443	BRD-K30331124	ASC-J9	AR	androgen receptor enhancer	Details
C00444	BRD-A72381333	ascomycin	FKBP1A	calcineurin inhibitor	Details
C00445	BRD-A85242401	ascorbic-acid	ALKBH2\|ALKBH3\|BBOX1\|DBH\|EGLN1\|EGLN2\|EGLN3\|KDM5D\|LCT\|OGFOD1\|OGFOD2\|P3H1\|P3H2\|P3H3\|P4HA1\|P4HTM\|PAM\|PHYH\|PLOD1\|PLOD2\|PLOD3\|SLC23A1\|SLC23A2\|TMLHE	antioxidant	Details
C00446	BRD-K95260951	asenapine	ADRA1A\|ADRA2A\|ADRA2B\|ADRA2C\|ADRB1\|ADRB2\|DRD1\|DRD2\|DRD3\|DRD4\|HRH1\|HRH2\|HTR1A\|HTR1B\|HTR1D\|HTR1E\|HTR2A\|HTR2B\|HTR2C\|HTR5A\|HTR6\|HTR7	dopamine receptor antagonist; serotonin receptor antagonist	Details
C00447	BRD-K35079116	asiatic-acid	PYGM	apoptosis stimulant	Details
C00448	BRD-K07150325	ASP-2535	SLC6A9	glycine transporter inhibitor	Details
C00449	BRD-K78841970	aspartame	TAS1R2\|TRPV1		Details
C00450	BRD-K11433652	aspirin	AKR1C1\|ASIC3\|EDNRA\|HSPA5\|IKBKB\|NFKB1\|NFKB2\|NFKBIA\|PRKAA1\|PRKAA2\|PRKAB1\|PRKAB2\|PRKAG1\|PRKAG2\|PRKAG3\|PTGS1\|PTGS2\|RPS6KA3\|TP53	cyclooxygenase inhibitor	Details
C00451	BRD-K06542892	ASP3026	ALK	ALK tyrosine kinase receptor inhibitor	Details
C00452	BRD-K26838195	AST-1306	EGFR\|ERBB2	EGFR inhibitor	Details
C00453	BRD-K51832961	astaxanthin		antioxidant	Details
C00454	BRD-K37249724	astemizole	HRH1\|KCNH1\|KCNH2	histamine receptor antagonist	Details
C00455	BRD-K08188887	astragaloside-a		antiinflammatory agent	Details
C00456	BRD-K87028197	asunaprevir		HCV inhibitor	Details
C00457	BRD-K36269323	asymmetrical-dimethylarginine	NOS2\|NOS3	nitric oxide synthase inhibitor	Details
C00458	BRD-K06496777	AT-1015	HTR2A	serotonin receptor antagonist	Details
C00459	BRD-K13390322	AT-7519	CDK1\|CDK2\|CDK4\|CDK5\|CDK6\|CDK9	CDK inhibitor	Details
C00460	BRD-K24576554	AT-9283	AURKA\|AURKB\|JAK2\|JAK3\|RPS6KA6\|STK17A	Aurora kinase inhibitor; JAK inhibitor	Details
C00461	BRD-K94830329	ataluren	DMD	CFTR channel agonist; dystrophin stimulant	Details
C00462	BRD-K09757388	atazanavir		HIV protease inhibitor	Details
C00463	BRD-A52551912	ATB-346	PTGER2	cyclooxygenase inhibitor	Details
C00464	BRD-K68075732	atenolol-(+)		adrenergic receptor antagonist	Details
C00465	BRD-A20239487	atenolol-(+/-)	ADRB1\|ADRB2	adrenergic receptor antagonist	Details
C00466	BRD-K44993696	atenolol-(-)		adrenergic receptor antagonist	Details
C00467	BRD-K43363084	atglistatin		adipose triglyceride lipase inhibitor	Details
C00468	BRD-K39252998	atipamezole		adrenergic receptor antagonist	Details
C00469	BRD-K38527262	atiprimod	JAK2\|STAT3	JAK inhibitor; STAT inhibitor	Details
C00470	BRD-K76614248	atizoram	PDE4A\|PDE4B\|PDE4C\|PDE4D	phosphodiesterase inhibitor	Details
C00471	BRD-K00521308	ATN-161	ITGA5\|ITGAV\|ITGB1\|ITGB3	integrin antagonist	Details
C00472	BRD-K20141153	atomoxetine	GRIN1\|GRIN2A\|GRIN2B\|GRIN2C\|GRIN2D\|GRIN3A\|GRIN3B\|SLC6A2\|SLC6A3\|SLC6A4	norepinephrine transporter inhibitor	Details
C00473	BRD-K69726342	atorvastatin	AHR\|DPP4\|HMGCR	HMGCR inhibitor	Details
C00474	BRD-A85261566	atosiban	AVPR1A\|AVPR1B\|AVPR2\|OXTR	oxytocin receptor antagonist	Details
C00475	BRD-A19795905	atovaquone	DHODH	mitochondrial electron transport inhibitor	Details
C00476	BRD-A65145453	ATPA	GRIA2\|GRIK1	glutamate receptor agonist	Details
C00477	BRD-A75935363	atracurium	CHRNA2	acetylcholine receptor antagonist	Details
C00478	BRD-K16295392	atrasentan	EDNRA	endothelin receptor antagonist	Details
C00479	BRD-A27290375	atropine	CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5	acetylcholine receptor antagonist	Details
C00480	BRD-A70067498	atropine-oxide		acetylcholine receptor antagonist	Details
C00481	BRD-K32127727	AT13148	AKT1\|AKT2\|AKT3\|ROCK1\|ROCK2\|SGK3	protein kinase inhibitor	Details
C00482	BRD-K58435339	AT13387	HSP90AA1	HSP antagonist	Details
C00483	BRD-K12040459	AT7867	AKT2\|GSK3B\|PKIA\|PRKACA	AKT inhibitor	Details
C00484	BRD-K73841932	auranofin	IKBKB\|PRDX5\|TRPA1	NFkB pathway inhibitor	Details
C00485	BRD-K53561341	aurora-a-inhibitor-i	AURKA	Aurora kinase inhibitor	Details
C00486	BRD-A89825407	aurothioglucose	PRKCI	PKC inhibitor	Details
C00487	BRD-A94640958	autotaxin-modulator-1	ENPP2	autotaxin inhibitor	Details
C00488	BRD-K23190681	AV-412	EGFR\|ERBB2	protein tyrosine kinase inhibitor	Details
C00489	BRD-K96615647	AV-608	TACR1	tachykinin antagonist	Details
C00490	BRD-K83720053	avagacestat	PSEN1	gamma secretase inhibitor	Details
C00491	BRD-K65781196	avanafil	PDE5A	phosphodiesterase inhibitor	Details
C00492	BRD-K67901620	avasimibe	CES1	ACAT inhibitor	Details
C00493	BRD-K68544925	avatrombopag	MPL	thrombopoietin receptor agonist	Details
C00494	BRD-K36154108	AVE-0991	MRGPRX1	angiotensin receptor agonist	Details
C00495	BRD-K85882401	avibactam		beta lactamase inhibitor	Details
C00496	BRD-K87782578	AVL-292	BTK\|YES1	Bruton's tyrosine kinase (BTK) inhibitor	Details
C00497	BRD-K62196610	AVN-944	IMPDH1\|IMPDH2	inosine monophosphate dehydrogenase inhibitor	Details
C00498	BRD-K14401183	avobenzone	TYR	UV blocker	Details
C00499	BRD-K26665484	avridine		immunostimulant	Details
C00500	BRD-K29905972	axitinib	CSF1\|FLT1\|FLT4\|KDR\|PLK4	PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor	Details