CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C04801 | BRD-K36395411 | SB-206553 | HTR2A|HTR2B|HTR2C | serotonin receptor antagonist | Details | |
| C04802 | BRD-K30867024 | SB-216641 | HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C | serotonin receptor antagonist | Details | |
| C04803 | BRD-K59184148 | SB-216763 | CCNA2|CDK2|GSK3A|GSK3B | glycogen synthase kinase inhibitor | Details | |
| C04804 | BRD-A06352508 | SB-218078 | CHEK1 | CHK inhibitor | Details | |
| C04805 | BRD-K61097567 | SB-218795 | TACR3 | tachykinin antagonist | Details | |
| C04806 | BRD-K14807180 | SB-221284 | HTR2A|HTR2B|HTR2C | serotonin receptor antagonist | Details | |
| C04807 | BRD-K04414442 | SB-222200 | TACR3 | tachykinin antagonist | Details | |
| C04808 | BRD-K61323504 | SB-225002 | CXCR2 | CC chemokine receptor antagonist | Details | |
| C04809 | BRD-K15424032 | SB-228357 | HTR2A|HTR2B|HTR2C | serotonin receptor antagonist | Details | |
| C04810 | BRD-K98795921 | SB-2343 | MTOR|PIK3CA|PIK3CB|PIK3CD|PIK3CG | mTOR inhibitor; PI3K inhibitor | Details | |
| C04811 | BRD-K82091397 | SB-239063 | MAPK11|MAPK14|PTGS2 | p38 MAPK inhibitor | Details | |
| C04812 | BRD-K19412355 | SB-242235 | HSPB1|MAPK14 | p38 MAPK inhibitor | Details | |
| C04813 | BRD-K99968849 | SB-243213 | HTR2A|HTR2B|HTR2C|HTR6 | serotonin receptor inverse agonist | Details | |
| C04814 | BRD-K80639402 | SB-258585 | HTR6 | serotonin receptor antagonist | Details | |
| C04815 | BRD-A91031770 | SB-268262 | CALCA | calcitonin antagonist | Details | |
| C04816 | BRD-K24201553 | SB-269970 | HTR7 | serotonin receptor antagonist | Details | |
| C04817 | BRD-K82467063 | SB-271046 | HTR6 | serotonin receptor antagonist | Details | |
| C04818 | BRD-K16107558 | SB-297006 | CCR3 | CC chemokine receptor antagonist | Details | |
| C04819 | BRD-K78720403 | SB-328437 | CCR antagonist | Details | ||
| C04820 | BRD-K41567364 | SB-334867 | HCRTR1|HCRTR2 | orexin receptor antagonist | Details | |
| C04821 | BRD-K61536336 | SB-366791 | TRPV1 | TRPV antagonist | Details | |
| C04822 | BRD-K03988082 | SB-399885 | HTR6 | serotonin receptor antagonist | Details | |
| C04823 | BRD-K53913732 | SB-408124 | HCRTR1|HCRTR2 | orexin receptor antagonist | Details | |
| C04824 | BRD-K76805682 | SB-415286 | GSK3A|GSK3B|RPS6KB1 | glycogen synthase kinase inhibitor | Details | |
| C04825 | BRD-K67298865 | SB-431542 | ACVR1C|TGFBR1 | TGF beta receptor inhibitor | Details | |
| C04826 | BRD-K03665769 | SB-452533 | TRPV1 | TRPV antagonist | Details | |
| C04827 | BRD-K40109029 | SB-505124 | TGFBR1 | ALK tyrosine kinase receptor inhibitor | Details | |
| C04828 | BRD-K37720887 | SB-525334 | TGFBR1 | TGF beta receptor inhibitor | Details | |
| C04829 | BRD-K78809024 | SB-590885 | BRAF | RAF inhibitor | Details | |
| C04830 | BRD-K08333979 | SB-612111 | OPRL1 | nociceptin/orphanin FQ (NOP) receptor antagonist | Details | |
| C04831 | BRD-K95292280 | SB-657510 | UTS2R | urotensin receptor antagonist | Details | |
| C04832 | BRD-K24968862 | SB-683698 | ITGA4|ITGAV|ITGB1|ITGB7 | integrin antagonist | Details | |
| C04833 | BRD-K65991129 | SB-705498 | TRPV1 | TRPV antagonist | Details | |
| C04834 | BRD-K68633027 | SB-706375 | UTS2R | urotensin receptor antagonist | Details | |
| C04835 | BRD-K78941306 | SB-742457 | HTR6 | serotonin receptor antagonist | Details | |
| C04836 | BRD-K68532323 | SB-743921 | KIF11 | kinesin-like spindle protein inhibitor | Details | |
| C04837 | BRD-K49597925 | SB-747651A | AKT1|AKT3|ROCK1|RPS6KA5|RPS6KB1 | kinase inhibitor | Details | |
| C04838 | BRD-K45168550 | SB-756050 | GPBAR1 | G protein-coupled receptor agonist | Details | |
| C04839 | BRD-K49110935 | SB-772077B | ROCK1|ROCK2 | rho associated kinase inhibitor | Details | |
| C04840 | BRD-K86797399 | SB-939 | HDAC1|HDAC10|HDAC3|HDAC4|HDAC5|HDAC9 | HDAC inhibitor | Details | |
| C04841 | BRD-K71667152 | SBE-13 | PLK1 | PLK inhibitor | Details | |
| C04842 | BRD-K54729176 | SBHA | HDAC1|HDAC3 | HDAC inhibitor | Details | |
| C04843 | BRD-K05361803 | SC-10 | PRKCA | protein kinase activator | Details | |
| C04844 | BRD-K40797222 | SC-12267 | IL17A | dihydroorotate dehydrogenase inhibitor | Details | |
| C04845 | BRD-K55305701 | SC-144 | P glycoprotein inhibitor | Details | ||
| C04846 | BRD-K52512893 | SC-19220 | PTGER1 | prostanoid receptor antagonist | Details | |
| C04847 | BRD-K76365178 | SC-236 | PTGS2 | cyclooxygenase inhibitor | Details | |
| C04848 | BRD-K62715847 | SC-51089 | PTGER1 | prostanoid receptor antagonist | Details | |
| C04849 | BRD-K14767410 | SC-560 | PTGS1 | cyclooxygenase inhibitor | Details | |
| C04850 | BRD-K25875056 | SC-9 | PRKCA | protein tyrosine kinase activator | Details | |
| C04851 | BRD-K29562203 | SCH-202676 | CHRM1|CHRM2|DRD1|DRD2 | G protein-coupled receptor modulator | Details | |
| C04852 | BRD-A06700447 | SCH-221510 | OPRL1 | nociceptin/orphanin FQ (NOP) receptor agonist | Details | |
| C04853 | BRD-K45435259 | SCH-23390 | DRD1|DRD5|HTR2C|KCNJ4|KCNJ6 | dopamine receptor antagonist | Details | |
| C04854 | BRD-K55748775 | SCH-28080 | ATP4A | ATPase inhibitor | Details | |
| C04855 | BRD-K02460719 | SCH-51344 | NUDT1 | MTH1 inhibitor | Details | |
| C04856 | BRD-K81225797 | SCH-58261 | ADORA1|ADORA2A|ADORA2B|ADORA3 | adenosine receptor antagonist | Details | |
| C04857 | BRD-K75009076 | SCH-900776 | CDK2|CHEK1 | CHK inhibitor | Details | |
| C04858 | BRD-K86294588 | schisandrin-b | ATR | antioxidant | Details | |
| C04859 | BRD-K18878288 | schisandrol-b | lipid peroxidase inhibitor | Details | ||
| C04860 | BRD-A23127772 | sclareol | Details | |||
| C04861 | BRD-K72925150 | sclareolide | other antifungal | Details | ||
| C04862 | BRD-K33809398 | SCMC-Lys | GSTP1 | mucolytic agent | Details | |
| C04863 | BRD-K75923785 | scopine | Details | |||
| C04864 | BRD-K89923877 | scopolamine | acetylcholine receptor antagonist | Details | ||
| C04865 | BRD-A49906757 | scopolamine-n-oxide | CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|SI | acetylcholine receptor antagonist | Details | |
| C04866 | BRD-K20548681 | SCP-1 | analgesic agent | Details | ||
| C04867 | BRD-K22503835 | scriptaid | HDAC1|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9 | HDAC inhibitor | Details | |
| C04868 | BRD-K78496197 | SCS | Details | |||
| C04869 | BRD-K91904471 | SD-169 | MAPK14 | p38 MAPK inhibitor | Details | |
| C04870 | BRD-K24566386 | SD-208 | TGFBR1 | TGF beta receptor inhibitor | Details | |
| C04871 | BRD-K51102532 | SD-2590 | MMP1|MMP13|MMP2 | matrix metalloprotease inhibitor | Details | |
| C04872 | BRD-A75769826 | SDM25N | OPRD1 | opioid receptor antagonist | Details | |
| C04873 | BRD-K65820248 | SDZ-NKT-343 | TACR1 | tachykinin antagonist | Details | |
| C04874 | BRD-K31339597 | SDZ-SER-082 | HTR2A|HTR2B|HTR2C | serotonin receptor antagonist | Details | |
| C04875 | BRD-K39558284 | SDZ-WAG-994 | ADORA1 | adenosine receptor agonist | Details | |
| C04876 | BRD-K15868788 | SDZ-205-557 | HTR3A|HTR3B | serotonin receptor antagonist | Details | |
| C04877 | BRD-A15530910 | SDZ-21009 | HTR1A|HTR1B | adrenergic receptor antagonist; serotonin receptor antagonist | Details | |
| C04878 | BRD-K82266792 | SDZ-220-040 | GRIN1 | glutamate receptor antagonist | Details | |
| C04879 | BRD-K27168049 | SDZ-220-581 | GRIN1 | glutamate receptor antagonist | Details | |
| C04880 | BRD-K74227499 | se-methylselenocysteine | Details | |||
| C04881 | BRD-K02965577 | secalciferol | VDR | vitamin D receptor agonist | Details | |
| C04882 | BRD-A53472930 | seclazone | anti-inflammatory agent | Details | ||
| C04883 | BRD-A70083328 | secnidazole | acetylcholinesterase inhibitor; microtubule inhibitor | Details | ||
| C04884 | BRD-K91733562 | secoisolariciresinol-(-) | Details | |||
| C04885 | BRD-K77320845 | secoisolariciresinol-diglucoside | antioxidant | Details | ||
| C04886 | BRD-K49071277 | securinine | GABRA1 | GABA receptor antagonist; TP53 activator | Details | |
| C04887 | BRD-A58564983 | selamectin | nematocide | Details | ||
| C04888 | BRD-A28545468 | selegiline | MAOA|MAOB | monoamine oxidase inhibitor | Details | |
| C04889 | BRD-A18774709 | selenomethionine | Details | |||
| C04890 | BRD-K21191422 | selexipag | PTGIR | platelet aggregation inhibitor; IP1 prostacyclin receptor agonist | Details | |
| C04891 | BRD-K48738253 | selfotel | GRIN2A|GRIN2B|GRIN2C|GRIN2D | glutamate receptor antagonist | Details | |
| C04892 | BRD-K21361524 | selinexor | XPO1 | exportin antagonist | Details | |
| C04893 | BRD-K57080016 | selumetinib | MAP2K1 | MEK inhibitor | Details | |
| C04894 | BRD-K81957469 | semagacestat | PSEN1 | gamma secretase inhibitor | Details | |
| C04895 | BRD-K21237892 | semapimod | MAPK14 | cytokine production inhibitor; p38 MAPK inhibitor | Details | |
| C04896 | BRD-K63504947 | semaxanib | FGFR1|FLT1|KDR|KIT|PDGFRA|PDGFRB|RET | VEGFR inhibitor | Details | |
| C04897 | BRD-K13281575 | semustine | DNA alkylating agent | Details | ||
| C04898 | BRD-K70614402 | SEN-1269 | APP | beta amyloid inhibitor | Details | |
| C04899 | BRD-K21295289 | senicapoc | KCNN4 | intermediate conductance potassium channel blocker | Details | |
| C04900 | BRD-A30370660 | sennoside-a | glycoside agonist | Details |