CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

CMap Candidates

CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.

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Associated NAFLD Targets:

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6125 records.

CMap ID	Pert ID	Compound Name	Targets	MoA
C04301	BRD-K67100011	pivmecillinam		bacterial cell wall synthesis inhibitor	Details
C04302	BRD-K48304345	pixantrone	TOP2A	topoisomerase inhibitor	Details
C04303	BRD-K75958195	pizotifen	HTR1A\|HTR2A\|HTR2C	serotonin receptor antagonist	Details
C04304	BRD-K62374002	PI3K-IN-2		PI3K inhibitor	Details
C04305	BRD-K75528696	PI4KIII-beta-inhibitor-1	PI4K2B	PI4K inhibitor	Details
C04306	BRD-K11853856	PJ-34	EEF2\|PARP1\|PARP15\|PARP3	PARP inhibitor	Details
C04307	BRD-K44043890	PK-THPP	KCNK9	potassium channel blocker	Details
C04308	BRD-A41451487	PK-11195	TSPO	benzodiazepine receptor antagonist	Details
C04309	BRD-K04035716	PK-44	DPP4	dipeptidyl peptidase inhibitor	Details
C04310	BRD-K10115470	PKI-166	EGFR	EGFR inhibitor	Details
C04311	BRD-A28467416	PKI-179	MTOR	mTOR inhibitor; PI3K inhibitor	Details
C04312	BRD-K27625831	pleconaril			Details
C04313	BRD-K33240821	plerixafor	ACKR3\|CCR4\|CXCR4	CC chemokine receptor antagonist	Details
C04314	BRD-K36368047	plicamycin		alcohol dehydrogenase inhibitor	Details
C04315	BRD-K99498722	plinabulin		tubulin polymerization inhibitor	Details
C04316	BRD-A20781140	plovamer-acetate	TAT\|TH\|YARS\|YARS2		Details
C04317	BRD-K99149715	plurisin-#1	SCD	stearoyl-CoA desaturase inhibitor	Details
C04318	BRD-K16478699	PLX-4720	BRAF\|KDR	RAF inhibitor	Details
C04319	BRD-K79294107	PLX-647	CSF1R\|KIT	receptor tyrosine protein kinase inhibitor	Details
C04320	BRD-K53723268	PLX8394	BRAF	serine/threonine kinase inhibitor	Details
C04321	BRD-A74387232	PMPA	FOLH1	glutamate receptor antagonist	Details
C04322	BRD-K71731651	PNU-120596	CHRNA7	acetylcholine receptor agonist	Details
C04323	BRD-K81616657	PNU-142633	HTR1D	serotonin receptor agonist	Details
C04324	BRD-K04635846	PNU-177864	DRD3	dopamine receptor antagonist	Details
C04325	BRD-K16551401	PNU-22394	HTR2A\|HTR2B\|HTR2C\|MAOA\|MAOB	serotonin receptor agonist	Details
C04326	BRD-K28863208	PNU-282987	CHRNA7	cholinergic receptor agonist	Details
C04327	BRD-K12769093	PNU-37883		ATP-sensitive potassium channel antagonist	Details
C04328	BRD-K30707190	PNU-74654	CTNNB1\|TCF4	beta-catenin inhibitor	Details
C04329	BRD-K84507776	PNU-89843	GABBR1	benzodiazepine receptor agonist	Details
C04330	BRD-K47869605	podophyllotoxin	IGF1R\|TOP2A\|TUBA4A\|TUBB	microtubule inhibitor; tubulin polymerization inhibitor	Details
C04331	BRD-K35798650	polidocanol		local anesthetic	Details
C04332	BRD-K43236057	polydatin	ICAM1	ICAM1 expression inhibitor	Details
C04333	BRD-A67531813	polyinosine	ADSSL1\|HPRT1\|IMPDH2\|PYGM	immunostimulant	Details
C04334	BRD-A08641215	polymyxin-b-sulfate		bacterial permeability inducer	Details
C04335	BRD-A15739803	polythiazide	SLC12A3	sodium/chloride cotransporter inhibitor	Details
C04336	BRD-A12994259	pomalidomide	CRBN\|PTGS2\|TNF	angiogenesis inhibitor; tumor necrosis factor production inhibitor	Details
C04337	BRD-K44227013	ponatinib	ABL1\|BCR\|FGFR1\|FGFR2\|FGFR3\|FGFR4\|FLT3\|KDR\|KIT\|LCK\|LYN\|PDGFRA\|RET\|SRC\|TEK	Bcr-Abl kinase inhibitor; FLT3 inhibitor; PDGFR tyrosine kinase receptor inhibitor	Details
C04338	BRD-K44030614	ponesimod	S1PR1	sphingosine 1 phosphate receptor agonist	Details
C04339	BRD-K06222852	posaconazole	CYP3A4	sterol demethylase inhibitor	Details
C04340	BRD-K46556543	potassium-canrenoate	NR3C2	mineralocorticoid receptor antagonist	Details
C04341	BRD-M55321172	potassium-iodide			Details
C04342	BRD-K58497451	potassium-p-aminobenzoate			Details
C04343	BRD-K79803033	pozanicline	CHRNA4\|CHRNB2	acetylcholine receptor antagonist	Details
C04344	BRD-K50010139	poziotinib	EGFR\|ERBB2\|ERBB4	EGFR inhibitor	Details
C04345	BRD-K47598052	PP-1	HCK\|RET	src inhibitor	Details
C04346	BRD-K81801188	PP-121	ABL1\|EGFR\|HCK\|KDR\|MTOR\|PDGFRA\|PIK3CA\|PIK3CB\|PIK3CD\|PIK3CG\|PRKDC\|SRC	protein tyrosine kinase inhibitor	Details
C04347	BRD-K95785537	PP-2	ABL1\|LCK\|LYN\|RIPK2\|SRC	src inhibitor	Details
C04348	BRD-K00312224	PPT	ESR1	estrogen receptor agonist	Details
C04349	BRD-K72514671	PPY-A	ABL1\|BCR	Abl kinase inhibitor	Details
C04350	BRD-K87112191	PP242	MTOR\|PASK	mTOR inhibitor	Details
C04351	BRD-K67537649	PQ-401	IGF1R	IGF-1 inhibitor	Details
C04352	BRD-K54395039	PR-619		DUB inhibitor	Details
C04353	BRD-A41304429	practolol	ADRB1	adrenergic receptor antagonist	Details
C04354	BRD-A74914197	pralatrexate	DHFR\|TYMS	dihydrofolate reductase inhibitor	Details
C04355	BRD-K84281997	pralidoxime	ACHE\|BCHE	acetylcholinesterase inhibitor	Details
C04356	BRD-K24221957	pralidoxime-chloride	ACHE\|BCHE	acetylcholinesterase inhibitor	Details
C04357	BRD-K06388322	pramipexole	ADRA2A\|ADRA2B\|ADRA2C\|DRD1\|DRD2\|DRD3\|DRD4\|DRD5\|HTR1A\|HTR1B\|HTR1D\|HTR2A\|HTR2B\|HTR2C	dopamine receptor agonist	Details
C04358	BRD-K21123171	pramiracetam		acetylcholine receptor agonist	Details
C04359	BRD-K46523383	pramoxine		topical anesthetic	Details
C04360	BRD-A68083442	pranidipine	CACNA1C	calcium channel blocker	Details
C04361	BRD-K97045029	pranlukast	CYSLTR1\|CYSLTR2\|IL5\|MUC2\|NFKB1\|RNASE3\|TNF	leukotriene receptor antagonist	Details
C04362	BRD-A64610707	pranoprofen		cyclooxygenase inhibitor	Details
C04363	BRD-A20758144	prasterone-acetate			Details
C04364	BRD-A83029242	prasugrel	P2RY12	purinergic receptor antagonist	Details
C04365	BRD-K46209126	pravadoline	CNR1\|CNR2	cyclooxygenase inhibitor	Details
C04366	BRD-K60511616	pravastatin	HMGCR\|SLCO1B1	HMGCR inhibitor	Details
C04367	BRD-A21858158	praziquantel		anthelmintic agent	Details
C04368	BRD-K49111258	prazosin	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C\|KCNH2\|KCNH6\|KCNH7	adrenergic receptor antagonist	Details
C04369	BRD-K57304726	PRE-084	SIGMAR1	sigma receptor agonist	Details
C04370	BRD-K02908048	preclamol	DRD2	dopamine receptor agonist	Details
C04371	BRD-A93963402	prednicarbate	NR3C1\|PLA2G1B	phospholipase activator	Details
C04372	BRD-A27887842	prednisolone	NR3C1\|NR3C2\|SERPINA6	glucocorticoid receptor agonist	Details
C04373	BRD-K45664306	prednisolone-acetate	NR3C1	glucocorticoid receptor agonist	Details
C04374	BRD-A78391468	prednisolone-hemisuccinate	NR3C1	glucocorticoid receptor agonist	Details
C04375	BRD-A94523291	prednisolone-sodium-phosphate	NR3C1	glucocorticoid receptor agonist	Details
C04376	BRD-A53151380	prednisolone-tebutate		anti-inflammatory agent	Details
C04377	BRD-K85883481	prednisone	HSD11B1\|NR3C1	glucocorticoid receptor agonist	Details
C04378	BRD-K66786476	pregabalin	CACNA1A\|CACNA1B\|CACNA1C\|CACNA1D\|CACNA1E\|CACNA1F\|CACNA1G\|CACNA1H\|CACNA1I\|CACNA1S\|CACNA2D1\|CACNA2D2\|CACNA2D3\|CACNA2D4\|CACNB1\|CACNB2\|CACNB3\|CACNB4\|CACNG1\|CACNG2\|CACNG3\|CACNG4\|CACNG5\|CACNG6\|CACNG7\|CACNG8	voltage-gated calcium channel ligand	Details
C04379	BRD-A03204438	pregnanolone		GABA receptor positive allosteric modulator	Details
C04380	BRD-K43880410	pregnenolone	CYP17A1\|SULT2B1	glutamate receptor modulator	Details
C04381	BRD-A35912562	pregnenolone-succinate		GABA receptor negative allosteric modulator	Details
C04382	BRD-K46290096	preladenant	ADORA1\|ADORA2A\|ADORA2B\|ADORA3	adenosine receptor antagonist	Details
C04383	BRD-A10662413	prenylamine	CALM1\|MYLK2	calcium channel blocker	Details
C04384	BRD-K45906612	presatovir		RSV fusion inhibitor	Details
C04385	BRD-K17565903	pridinol		muscle relaxant	Details
C04386	BRD-A53952395	prilocaine	SCN10A\|SCN11A\|SCN1A\|SCN2A\|SCN3A\|SCN4A\|SCN5A\|SCN7A\|SCN8A\|SCN9A	local anesthetic	Details
C04387	BRD-A55913614	primaquine	KRT7\|NQO2	antimalarial agent; DNA inhibitor	Details
C04388	BRD-K15318909	PRIMA1	TP53	TP53 reactivator	Details
C04389	BRD-K32247306	primidone	CHRNA4\|CHRNA7\|GABRA1\|GABRA2\|GABRA3\|GABRA4\|GABRA5\|GABRA6\|GABRB1\|GABRB2\|GABRB3\|GABRD\|GABRE\|GABRG1\|GABRG2\|GABRG3\|GABRP\|GABRQ\|GRIA2\|GRIK2\|SCN10A\|SCN11A\|SCN1A\|SCN2A\|SCN3A\|SCN4A\|SCN5A\|SCN7A\|SCN8A\|SCN9A	GABA receptor antagonist	Details
C04390	BRD-K87316765	prinaberel	ESR2\|NCOA1	estrogen receptor agonist	Details
C04391	BRD-K01662324	priralfinamide	CACNA1B	sodium channel blocker	Details
C04392	BRD-K25204779	pritelivir		helicase primase inhibitor	Details
C04393	BRD-K53605365	proacipimox		cholesterol inhibitor	Details
C04394	BRD-K46317332	proadifen	NOS1	nitric oxide synthase inhibitor	Details
C04395	BRD-K95237249	probenecid	PANX1\|SLC22A11\|SLC22A6\|SLC22A8\|SLCO1C1	uricosuric blocker	Details
C04396	BRD-K72029282	probucol	ABCA1\|ABCB11\|CES1	atherogenesis inhibitor	Details
C04397	BRD-K75089421	procainamide	DNMT1\|SCN5A	sodium channel blocker	Details
C04398	BRD-K24616672	procaine	CHRNA2\|GRIN3A\|HTR3A\|KCNMA1\|KCNMB1\|KCNMB2\|KCNMB3\|KCNMB4\|KCNN1\|KCNN2\|KCNN3\|KCNN4\|MAOA\|MAOB\|RYR1\|RYR2\|SCN10A\|SLC6A3	HMGCR inhibitor	Details
C04399	BRD-K13032584	procarbazine		monoamine oxidase inhibitor	Details
C04400	BRD-K78666826	procaterol	ADRB2	adrenergic receptor agonist	Details