CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C04501 | BRD-M55114534 | pyrvinium-pamoate | AR | androgen receptor antagonist | Details | |
| C04502 | BRD-K97714174 | P22077 | USP7 | ubiquitin specific protease inhibitor | Details | |
| C04503 | BRD-K51791723 | P276-00 | CDK1|CDK4|CDK9 | CDK inhibitor | Details | |
| C04504 | BRD-K13606314 | P5091 | USP7 | ubiquitin specific protease inhibitor | Details | |
| C04505 | BRD-A09487507 | P7C3 | NAMPT | NAMPT inhibitor | Details | |
| C04506 | BRD-K59853741 | Q-203 | ATP synthase inhibitor | Details | ||
| C04507 | BRD-K63631219 | quazinone | PDE3A|PDE3B | phosphodiesterase inhibitor | Details | |
| C04508 | BRD-K97399794 | quercetin | ATP5A1|ATP5B|ATP5C1|HCK|HIBCH|PIK3CG|PIM1|STK17B|UGT3A1 | polar auxin transport inhibitor | Details | |
| C04509 | BRD-K68867920 | quetiapine | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2C|HTR3A|HTR6|HTR7|SLC6A2 | dopamine receptor antagonist; serotonin receptor antagonist | Details | |
| C04510 | BRD-K39503511 | quiflapon | ALOX5|ALOX5AP | leukotriene synthesis inhibitor | Details | |
| C04511 | BRD-K02995728 | quinagolide | DRD2 | dopamine receptor agonist | Details | |
| C04512 | BRD-K72222507 | quinapril | ACE | angiotensin converting enzyme inhibitor | Details | |
| C04513 | BRD-K42317111 | quinaprilat | ACE | angiotensin converting enzyme inhibitor | Details | |
| C04514 | BRD-K13261168 | quinelorane | DRD2|DRD3 | dopamine receptor agonist | Details | |
| C04515 | BRD-A16439188 | quinestrol | ESR1 | estrogen receptor agonist | Details | |
| C04516 | BRD-A59303141 | quinethazone | CA1|CA2|SLC12A1|SLC12A2|SLC12A3 | thiazide diuretic | Details | |
| C04517 | BRD-K59632282 | quinidine | KCNA5|KCNA7|KCNH1|KCNH2|KCNH5|KCNK1|KCNK6|SCN5A|SLC29A4 | sodium channel blocker | Details | |
| C04518 | BRD-K07940445 | quinine | GP9|KCNB2|KCNN4|SLC29A4 | hemozoin biocrystallization inhibitor | Details | |
| C04519 | BRD-K97028990 | quinine-ethyl-carbonate | Details | |||
| C04520 | BRD-K51885093 | quinolinic-acid | glutamate receptor agonist | Details | ||
| C04521 | BRD-K26548821 | quinpirol-(-) | DRD1|DRD2|DRD3|DRD4|HTR1A|HTR2A|HTR2B|HTR2C | dopamine receptor agonist | Details | |
| C04522 | BRD-K77925998 | quipazine | serotonin receptor agonist | Details | ||
| C04523 | BRD-K93918653 | quizartinib | CSF1R|FLT3|KIT|PDGFRA|PDGFRB|RET | FLT3 inhibitor | Details | |
| C04524 | BRD-K40782193 | QX-222 | sodium channel blocker | Details | ||
| C04525 | BRD-K56596464 | QX-314 | MAPK14|TGFBR1 | sodium channel blocker | Details | |
| C04526 | BRD-A35931254 | r(-)-apomorphine | DRD2|HTR5A | dopamine receptor agonist | Details | |
| C04527 | BRD-K28442028 | R-1479 | HCV inhibitor | Details | ||
| C04528 | BRD-K96418224 | R-1485 | HTR6 | serotonin receptor antagonist | Details | |
| C04529 | BRD-K83904070 | R-268712 | TGFBR1 | serine/threonine kinase inhibitor | Details | |
| C04530 | BRD-K14870255 | R-428 | AXL | AXL kinase inhibitor | Details | |
| C04531 | BRD-K54665485 | R-59022 | DGKA | diacylglycerol kinase inhibitor; protein kinase inhibitor | Details | |
| C04532 | BRD-K15588452 | R-96544 | HTR2A | serotonin receptor antagonist | Details | |
| C04533 | BRD-A39390670 | rabeprazole | ATP4A | ATPase inhibitor; gastrin inhibitor | Details | |
| C04534 | BRD-A11069678 | rac-BHFF | GABBR1 | GABA receptor positive allosteric modulator | Details | |
| C04535 | BRD-A08187463 | racecadotril | MME | enkephalinase inhibitor | Details | |
| C04536 | BRD-K04111260 | raclopride | DRD2|DRD3|HTR1A | dopamine receptor antagonist | Details | |
| C04537 | BRD-A86414188 | ractopamine | adrenergic receptor agonist | Details | ||
| C04538 | BRD-K13394247 | radafaxine | SLC6A3 | dopamine norepinephrine reuptake inhibitor | Details | |
| C04539 | BRD-K84683831 | radezolid | bacterial 30S ribosomal subunit inhibitor; bacterial 50S ribosomal subunit inhibitor | Details | ||
| C04540 | BRD-K93123848 | RAF265 | BRAF | RAF inhibitor; VEGFR inhibitor | Details | |
| C04541 | BRD-K63828191 | raloxifene | ESR1|ESR2 | estrogen receptor antagonist; selective estrogen receptor modulator (SERM) | Details | |
| C04542 | BRD-K05658747 | raltegravir | HIV integrase inhibitor | Details | ||
| C04543 | BRD-K89839824 | raltitrexed | FPGS|TYMS | thymidylate synthase inhibitor | Details | |
| C04544 | BRD-K08586861 | ramatroban | PTGDR2|TBXA2R | prostanoid receptor antagonist | Details | |
| C04545 | BRD-K28761891 | ramelteon | MTNR1A|MTNR1B | melatonin receptor agonist | Details | |
| C04546 | BRD-K85333151 | ramifenazone | cyclooxygenase inhibitor | Details | ||
| C04547 | BRD-K89348303 | ramipril | ACE | angiotensin converting enzyme inhibitor | Details | |
| C04548 | BRD-K85046107 | ramosetron | HTR3A | serotonin receptor antagonist | Details | |
| C04549 | BRD-K50489389 | ranirestat | AKR1B1 | aldose reductase inhibitor | Details | |
| C04550 | BRD-K70505054 | ranitidine | HRH2 | histamine receptor antagonist | Details | |
| C04551 | BRD-A97674275 | ranolazine | SCN10A|SCN4A|SCN5A|SCN9A | sodium channel blocker | Details | |
| C04552 | BRD-K02206208 | rapastinel | glutamate receptor agonist | Details | ||
| C04553 | BRD-K58114536 | rasagiline | BCL2|MAOB | monoamine oxidase inhibitor | Details | |
| C04554 | BRD-K77474816 | rauwolscine | ADRA2A|ADRA2B|ADRA2C|HTR1B|HTR1D|HTR1E|HTR2B | adrenergic receptor antagonist | Details | |
| C04555 | BRD-K86309810 | ravoxertinib | MAPK1|MAPK3 | ERK1 and ERK2 phosphorylation inhibitor | Details | |
| C04556 | BRD-K03503561 | ravuconazole | sterol demethylase inhibitor | Details | ||
| C04557 | BRD-A67036568 | RBC8 | RALA|RALB | Ral GTPase inhibitor | Details | |
| C04558 | BRD-A15909516 | rebamipide | FPR1 | free radical scavenger | Details | |
| C04559 | BRD-K76694128 | rebastinib | ABL1|BCR|FGR|FLT3|HCK|LYN|SRC | Bcr-Abl kinase inhibitor; TIE tyrosine kinase inhibitor; VEGFR inhibitor | Details | |
| C04560 | BRD-M39350793 | reboxetine | SLC6A2 | adrenergic receptor antagonist | Details | |
| C04561 | BRD-K84924479 | Rec-15/2615 | ADRA1A | adrenergic receptor antagonist | Details | |
| C04562 | BRD-K85751432 | refametinib | MAP2K1|MAP2K2 | MEK inhibitor | Details | |
| C04563 | BRD-A78341343 | regadenoson | ADORA1|ADORA2A|ADORA2B|ADORA3 | adenosine receptor agonist | Details | |
| C04564 | BRD-K16730910 | regorafenib | ABL1|BRAF|DDR2|EPHA2|FGFR1|FGFR2|FLT1|FLT4|FRK|KDR|KIT|MAPK11|NTRK1|PDGFRA|PDGFRB|RAF1|RET|TEK | FGFR inhibitor; KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor; RAF inhibitor; RET tyrosine kinase inhibitor; VEGFR inhibitor | Details | |
| C04565 | BRD-K96720755 | relcovaptan | AVPR1A|AVPR1B|AVPR2|OXTR | vasopressin receptor antagonist | Details | |
| C04566 | BRD-K63018010 | relebactam | beta lactamase inhibitor | Details | ||
| C04567 | BRD-A36074203 | remacemide | GRIN1 | glutamate receptor antagonist | Details | |
| C04568 | BRD-K89413285 | remimazolam | GABBR1 | benzodiazepine receptor agonist | Details | |
| C04569 | BRD-K75349868 | remodelin | NAT10 | transferase inhibitor | Details | |
| C04570 | BRD-K54094468 | remoxipride | DRD2|DRD3|DRD4|HTR2A|SIGMAR1 | dopamine receptor antagonist | Details | |
| C04571 | BRD-K82846253 | repaglinide | ABCC8|KCNJ11|PPARG | insulin secretagogue | Details | |
| C04572 | BRD-K58486055 | reparixin | CXCR1|CXCR2 | CC chemokine receptor antagonist | Details | |
| C04573 | BRD-K80480517 | repsox | TGFBR1 | TGF beta receptor inhibitor | Details | |
| C04574 | BRD-K61567297 | resatorvid | TLR4 | toll-like receptor antagonist | Details | |
| C04575 | BRD-K95921201 | reserpine | SLC18A1|SLC18A2 | vesicular monoamine transporter inhibitor | Details | |
| C04576 | BRD-K25970317 | resibufogenin | Na/K-ATPase inhibitor | Details | ||
| C04577 | BRD-K76210423 | resiquimod | TLR7|TLR8 | toll-like receptor agonist | Details | |
| C04578 | BRD-K28822270 | resminostat | HDAC1|HDAC3|HDAC6|HDAC8 | HDAC inhibitor | Details | |
| C04579 | BRD-K74190368 | resorcinol | CA12|CA14|CA2|PTGS1 | phosphodiesterase inhibitor | Details | |
| C04580 | BRD-K85603128 | resorcinol-monoacetate | antiseptic | Details | ||
| C04581 | BRD-K80738081 | resveratrol | CSNK2A1|NQO2|PTGS1|PTGS2 | cytochrome P450 inhibitor; SIRT activator | Details | |
| C04582 | BRD-K33082088 | retapamulin | protein synthesis inhibitor | Details | ||
| C04583 | BRD-K67935717 | retaspimycin | HSP90AA1 | HSP inhibitor | Details | |
| C04584 | BRD-K89917372 | retigabine | KCNQ1|KCNQ2|KCNQ3|KCNQ4|KCNQ5 | potassium channel activator | Details | |
| C04585 | BRD-K79884267 | retinaldehyde | Details | |||
| C04586 | BRD-K22429181 | retinol | ALDH1A1|ALDH1A2|ALDH1A3|DHRS3|DHRS4|LRAT|NR2C2|RBP1|RBP3|RDH11|RDH12|RDH13|RDH14|RDH5|RDH8|RETSAT|RHO|RLBP1|RXRA|RXRB|RXRG | retinoid receptor ligand | Details | |
| C04587 | BRD-K65331431 | retinyl-acetate | Details | |||
| C04588 | BRD-K80595380 | retinyl-palmitate | Details | |||
| C04589 | BRD-A68281735 | REV-5901 | ALOX5 | leukotriene receptor antagonist; lipoxygenase inhibitor | Details | |
| C04590 | BRD-A51497544 | revaprazan | ATP4A | potassium-competitive acid antagonist | Details | |
| C04591 | BRD-K79700588 | reversan | ABCC1 | MRP inhibitor | Details | |
| C04592 | BRD-K77286328 | reversine | AURKB|INCENP|MAP2K1 | Aurora kinase inhibitor | Details | |
| C04593 | BRD-K20986415 | RGB-286638 | CDK1|CDK2|CDK3|CDK4|CDK5|CDK6|CDK7|CDK9|FLT3|GSK3B|JAK2|MAP3K7|MAPK9 | CDK inhibitor | Details | |
| C04594 | BRD-K61688984 | RGFP966 | HDAC3 | HDAC inhibitor | Details | |
| C04595 | BRD-K89391146 | RG108 | DNMT1|DNMT3B | DNA methyltransferase inhibitor | Details | |
| C04596 | BRD-K32942258 | RG1530 | FGFR1|FGFR2 | FGFR inhibitor; PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor | Details | |
| C04597 | BRD-K02389548 | RG2833 | HDAC1|HDAC3 | HDAC inhibitor | Details | |
| C04598 | BRD-K22024824 | RG4733 | PSEN1 | gamma secretase inhibitor | Details | |
| C04599 | BRD-A78210457 | RG7112 | MDM2 | MDM inhibitor | Details | |
| C04600 | BRD-K56047318 | RHC-80267 | DAGLA|DAGLB | triacylglycerol lipase inhibitor | Details |