CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C03101 | BRD-K62858456 | lomerizine | CACNA1B|SCN5A | calcium channel blocker | Details | |
| C03102 | BRD-K66036108 | lometrexol | GART|MTHFD1 | glycinamide ribonucleotide formyltransferase inhibitor | Details | |
| C03103 | BRD-K92213669 | lomitapide | MTTP | microsomal trigylceride transfer protein inhibitor | Details | |
| C03104 | BRD-K51768138 | lomustine | STMN4 | DNA synthesis inhibitor | Details | |
| C03105 | BRD-K41599323 | lonafarnib | FNTA|HRAS|KRAS|NRAS | farnesyltransferase inhibitor | Details | |
| C03106 | BRD-K78513633 | lonidamine | GCK | glucokinase inhibitor | Details | |
| C03107 | BRD-K61250553 | loperamide | CACNA1A|CALM1|OPRD1|OPRK1|OPRM1|POMC | opioid receptor agonist | Details | |
| C03108 | BRD-K99451608 | lopinavir | HIV protease inhibitor | Details | ||
| C03109 | BRD-A04915500 | loracarbef | bacterial cell wall synthesis inhibitor | Details | ||
| C03110 | BRD-K82795137 | loratadine | HRH1 | histamine receptor antagonist | Details | |
| C03111 | BRD-A11990600 | lorazepam | GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|TSPO | benzodiazepine receptor agonist | Details | |
| C03112 | BRD-K55013654 | lorcaserin | HTR2A|HTR2B|HTR2C | serotonin receptor agonist | Details | |
| C03113 | BRD-K09659835 | loreclezole | GABRB2|GABRB3 | benzodiazepine receptor agonist | Details | |
| C03114 | BRD-K42066335 | lorediplon | GABRA1 | GABA receptor modulator | Details | |
| C03115 | BRD-A29854054 | lorglumide | CCKAR|CCKBR | CCK receptor antagonist | Details | |
| C03116 | BRD-K99879819 | lorlatinib | ALK | ALK tyrosine kinase receptor inhibitor | Details | |
| C03117 | BRD-A90551241 | lornoxicam | PTGS1|PTGS2 | cyclooxygenase inhibitor | Details | |
| C03118 | BRD-K76205745 | losartan | AGTR1 | angiotensin receptor antagonist | Details | |
| C03119 | BRD-K56195681 | losmapimod | MAPK14 | p38 MAPK inhibitor | Details | |
| C03120 | BRD-K39983086 | loteprednol | NR3C1 | glucocorticoid receptor agonist; phospholipase inhibitor | Details | |
| C03121 | BRD-K09416995 | lovastatin | HDAC2|HMGCR|ITGAL|NR1I2 | HMGCR inhibitor | Details | |
| C03122 | BRD-K39915878 | loxapine | ADRA1A|ADRA1B|ADRA2A|ADRA2B|ADRA2C|ADRB1|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HRH2|HRH4|HTR1A|HTR1B|HTR1D|HTR1E|HTR2A|HTR2C|HTR3A|HTR5A|HTR6|HTR7|SLC6A2|SLC6A3|SLC6A4 | dopamine receptor antagonist; serotonin receptor antagonist | Details | |
| C03123 | BRD-K21937671 | loxistatin-acid | CTSB | cysteine peptidase inhibitor | Details | |
| C03124 | BRD-K36574127 | LOXO-101 | NTRK1|NTRK2|NTRK3 | tropomyosin receptor kinase inhibitor | Details | |
| C03125 | BRD-A43082555 | loxoprofen | PTGS2 | cyclooxygenase inhibitor; prostanoid receptor antagonist | Details | |
| C03126 | BRD-K32322923 | LPA2-antagonist-1 | LPAR2 | lysophosphatidic acid receptor antagonist | Details | |
| C03127 | BRD-K01436366 | LRRK2-IN-1 | LRRK2 | leucine rich repeat kinase inhibitor | Details | |
| C03128 | BRD-K79337272 | LSN-2463359 | GRM5 | glutamate receptor positive allosteric modulator | Details | |
| C03129 | BRD-K52914072 | LTA | Details | |||
| C03130 | BRD-K53124401 | LTB4 | LTB4R|LTB4R2 | leukocyte activator | Details | |
| C03131 | BRD-K83970940 | Lu-AA-47070 | ADORA2A | adenosine receptor antagonist | Details | |
| C03132 | BRD-K33814251 | lubiprostone | CLCN2 | chloride channel activator | Details | |
| C03133 | BRD-K31309378 | lucitanib | FGFR1|FLT1|KDR|KIT|PDGFRA|PDGFRB|RET | FGFR inhibitor; VEGFR inhibitor | Details | |
| C03134 | BRD-K67079690 | LUF-5834 | ADORA2A|ADORA2B | adenosine receptor agonist | Details | |
| C03135 | BRD-A71774530 | lufenuron | chitin inhibitor | Details | ||
| C03136 | BRD-K71058253 | luliconazole | sterol demethylase inhibitor | Details | ||
| C03137 | BRD-K69236721 | lumacaftor | CFTR | CFTR channel agonist | Details | |
| C03138 | BRD-K10031916 | lumateperone | DRD2|HTR2A | serotonin receptor antagonist; dopamine receptor modulator | Details | |
| C03139 | BRD-A05926236 | lumefantrine | ATP1A1 | antimalarial agent | Details | |
| C03140 | BRD-K26901728 | lumiracoxib | PTGS1|PTGS2 | cyclooxygenase inhibitor | Details | |
| C03141 | BRD-A92826379 | lupanine | INS | sodium channel blocker | Details | |
| C03142 | BRD-K51143828 | lurasidone | ADRA2A|ADRA2C|DRD2|HTR1A|HTR2A|HTR7 | dopamine receptor antagonist; serotonin receptor antagonist | Details | |
| C03143 | BRD-K16742848 | lutein | antioxidant | Details | ||
| C03144 | BRD-K05236810 | luteolin | TOP1 | glucosidase inhibitor | Details | |
| C03145 | BRD-K67013324 | luzindole | MTNR1A|MTNR1B | melatonin receptor antagonist | Details | |
| C03146 | BRD-K54520417 | LXR-623 | AR|NR1H2|NR1H3|NR1I2|NR3C1 | LXR agonist | Details | |
| C03147 | BRD-K32101625 | LX1031 | TPH1 | tryptophan hydroxylase inhibitor | Details | |
| C03148 | BRD-K21038058 | LX7101 | LIMK2|ROCK1|ROCK2 | LIM kinase inhibitor; rho associated kinase inhibitor | Details | |
| C03149 | BRD-A50062753 | LY-404187 | GRIA1|GRIA2|GRIA3|GRIA4 | glutamate receptor positive allosteric modulator | Details | |
| C03150 | BRD-K37083340 | lycopene | free radical scavenger | Details | ||
| C03151 | BRD-K62289640 | lylamine | CNR1 | cannabinoid receptor agonist | Details | |
| C03152 | BRD-A15750551 | lymecycline | bacterial 50S ribosomal subunit inhibitor | Details | ||
| C03153 | BRD-K39707084 | lynestrenol | progestogen hormone | Details | ||
| C03154 | BRD-K93331255 | lypressin | AVPR1A|AVPR1B|AVPR2 | vasopressin receptor agonist | Details | |
| C03155 | BRD-K78055238 | LY2090314 | GSK3B | glycogen synthase kinase inhibitor | Details | |
| C03156 | BRD-K47557313 | LY2109761 | TGFBR1|TGFBR2 | TGF beta receptor inhibitor | Details | |
| C03157 | BRD-K49519144 | LY2140023 | GRM3 | glutamate receptor agonist | Details | |
| C03158 | BRD-K34313798 | LY215490 | GRIA1|GRIA2|GRIA3|GRIA4|GRIK1 | glutamate receptor antagonist | Details | |
| C03159 | BRD-K78118466 | LY2157299 | TGFBR1 | TGF beta receptor inhibitor | Details | |
| C03160 | BRD-K37865504 | LY2183240 | FAAH | FAAH inhibitor; FAAH reuptake inhibitor | Details | |
| C03161 | BRD-K59227464 | LY2228820 | MAPK14 | p38 MAPK inhibitor | Details | |
| C03162 | BRD-K35367061 | LY223982 | LTB4R | leukotriene receptor antagonist | Details | |
| C03163 | BRD-K33864865 | LY225910 | CCKBR | CCK receptor antagonist | Details | |
| C03164 | BRD-K85804405 | LY231617 | lipid peroxidase inhibitor | Details | ||
| C03165 | BRD-K04993719 | LY2334737 | antitumor agent; ribonucleotide reductase inhibitor | Details | ||
| C03166 | BRD-K13888115 | LY2365109 | SLC6A9 | Glycine transporter 1 inhibitor | Details | |
| C03167 | BRD-K90171280 | LY2452473 | AR | androgen receptor modulator | Details | |
| C03168 | BRD-K92492521 | LY255283 | LTB4R|LTB4R2 | leukotriene receptor antagonist | Details | |
| C03169 | BRD-K21833260 | LY2584702 | RPS6KB1 | ribosomal protein inhibitor | Details | |
| C03170 | BRD-K14109347 | LY2603618 | CHEK1 | CHK inhibitor | Details | |
| C03171 | BRD-K20463415 | LY2606368 | CHEK1 | CHK inhibitor | Details | |
| C03172 | BRD-K12068470 | LY2608204 | GCK | glucokinase activator | Details | |
| C03173 | BRD-A64004759 | LY266097 | HTR2B | serotonin receptor antagonist | Details | |
| C03174 | BRD-K25630527 | LY2784544 | JAK2|JAK3 | JAK inhibitor | Details | |
| C03175 | BRD-K18961567 | LY2801653 | MET | MET inhibitor | Details | |
| C03176 | BRD-K94534639 | LY2811376 | BACE1 | beta-secretase inhibitor | Details | |
| C03177 | BRD-K15382985 | LY2857785 | CDK9 | CDK inhibitor | Details | |
| C03178 | BRD-K17203476 | LY2874455 | FGFR1|FGFR2|FGFR3|FGFR4|KDR | FGFR antagonist | Details | |
| C03179 | BRD-K24675965 | LY288513 | CCKBR | CCK receptor antagonist | Details | |
| C03180 | BRD-K17953908 | LY2886721 | BACE1 | beta-secretase inhibitor | Details | |
| C03181 | BRD-K27305650 | LY294002 | AKT1|CHEK1|GSK3B|LCK|MAPK1|MAPK11|MAPK12|MAPK14|MAPK8|MTOR|PIK3CA|PIK3CB|PIK3CD|PIK3CG|PLK1|PRKCA|PRKDC|ROCK1|RPS6KB1|SGK1 | mTOR inhibitor; PI3K inhibitor; DNA dependent protein kinase inhibitor; phosphodiesterase inhibitor; PLK inhibitor | Details | |
| C03182 | BRD-K68220839 | LY2979165 | GRM2 | glutamate receptor agonist | Details | |
| C03183 | BRD-K21070437 | LY3000328 | CTSS | cathepsin inhibitor | Details | |
| C03184 | BRD-K38385169 | LY3009120 | BRAF|RAF1 | RAF inhibitor | Details | |
| C03185 | BRD-K82967180 | LY3023414 | MTOR | PI3K inhibitor; mTOR inhibitor | Details | |
| C03186 | BRD-K22385716 | LY303511 | BRD2|BRD3|BRD4 | casein kinase inhibitor; mTOR inhibitor; PI3K inhibitor | Details | |
| C03187 | BRD-K41194171 | LY310762 | HTR1D | serotonin receptor antagonist | Details | |
| C03188 | BRD-K78637815 | LY320135 | CNR1 | cannabinoid receptor antagonist | Details | |
| C03189 | BRD-K95899059 | LY344864 | HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR7 | serotonin receptor agonist | Details | |
| C03190 | BRD-K06234293 | LY364947 | TGFBR1 | TGF beta receptor inhibitor; p38 MAPK inhibitor | Details | |
| C03191 | BRD-K08534264 | LY393558 | HTR1B|HTR1D|HTR2A|HTR2B | serotonin receptor antagonist | Details | |
| C03192 | BRD-K20013301 | LY411575 | gamma secretase inhibitor | Details | ||
| C03193 | BRD-K54538117 | LY450108 | glutamate receptor modulator | Details | ||
| C03194 | BRD-K87696786 | LY456236 | GRM1 | glutamate receptor antagonist | Details | |
| C03195 | BRD-K36965586 | m-Chlorophenylbiguanide | HTR3A|HTR3B | Details | ||
| C03196 | BRD-K91147684 | m-THP | Details | |||
| C03197 | BRD-A96977263 | M-14157 | KCNQ1 | ATP-sensitive potassium channel antagonist | Details | |
| C03198 | BRD-K51265828 | M-25 | DHH|IHH|SMO | smoothened receptor antagonist | Details | |
| C03199 | BRD-K09635314 | m-3M3FBS | PLCB2|PLCB3|PLCD1|PLCG1|PLCG2 | Details | ||
| C03200 | BRD-K45528773 | M-344 | HDAC inhibitor | Details |