CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C03401 | BRD-A19661776 | mianserin | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|DRD1|DRD2|DRD3|DRD5|HRH1|HRH2|HRH4|HTR1A|HTR1F|HTR2A|HTR2B|HTR2C|HTR6|HTR7|OPRK1|SLC6A2|SLC6A3|SLC6A4 | serotonin receptor antagonist | Details | |
| C03402 | BRD-K42981054 | mibampator | GRIA1 | glutamate receptor modulator | Details | |
| C03403 | BRD-K09549677 | mibefradil | ANO1|CACNA1C|CACNA1D|CACNA1F|CACNA1G|CACNA1H|CACNA1I|CACNA1S|CACNB1|CACNB2|CACNB3|CACNB4|CATSPER1|CATSPER2|CATSPER3|CATSPER4 | T-type calcium channel blocker | Details | |
| C03404 | BRD-K40407248 | micafungin | fungal 1,3-beta-D-glucan synthase inhibitor | Details | ||
| C03405 | BRD-A82396632 | miconazole | KCNH2|KCNH6|KCNH7|KCNMA1|KCNMB1|KCNMB2|KCNMB3|KCNMB4|KCNN1|KCNN2|KCNN3|KCNN4|NOS2|NOS3|TRPM2|TRPV5 | bacterial cell wall synthesis inhibitor | Details | |
| C03406 | BRD-K18552138 | micronomicin | protein synthesis inhibitor | Details | ||
| C03407 | BRD-K45163704 | midafotel | GRIN2A|GRIN2B|GRIN2C|GRIN2D | glutamate receptor antagonist | Details | |
| C03408 | BRD-K68822425 | midecamycin | protein synthesis inhibitor | Details | ||
| C03409 | BRD-A79981887 | midodrine | ADRA1A|ADRA1B|ADRA1D | adrenergic receptor agonist | Details | |
| C03410 | BRD-K13646352 | midostaurin | FLT3|PRKCG | FLT3 inhibitor; KIT inhibitor; PKC inhibitor | Details | |
| C03411 | BRD-K37270826 | mifepristone | AR|NR1I2|NR3C1|PGR | glucocorticoid receptor antagonist; progesterone receptor antagonist | Details | |
| C03412 | BRD-A72066420 | mifobate | PPARG | PPAR receptor antagonist | Details | |
| C03413 | BRD-K44779798 | miglitol | GAA|GANAB|GANC|MGAM | glucosidase inhibitor | Details | |
| C03414 | BRD-K33251802 | miglustat | UGCG | Glycosyl transferase inhibitor | Details | |
| C03415 | BRD-K64338723 | milacemide | MAOB | monoamine oxidase inhibitor | Details | |
| C03416 | BRD-A15202882 | milnacipran | GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B|SLC6A2|SLC6A4 | serotonin norepinephrine reuptake inhibitor (SNRI) | Details | |
| C03417 | BRD-K67080878 | milrinone | PDE2A|PDE3A|PDE3B|PDE5A | phosphodiesterase inhibitor | Details | |
| C03418 | BRD-A31811760 | miltefosine | PLA2G1B | membrane integrity inhibitor | Details | |
| C03419 | BRD-K67642028 | mimosine | CCL2|SHMT1|SHMT2|TYR | DNA replication inhibitor | Details | |
| C03420 | BRD-K02867583 | minaprine | ACHE|CHRM1|DRD1|DRD2|HTR2A|HTR2B|HTR2C|MAOA|SLC6A4 | serotonin reuptake inhibitor | Details | |
| C03421 | BRD-A74347210 | minerval | FAAH inhibitor | Details | ||
| C03422 | BRD-A69651145 | minocycline | ALOX5|CASP1|CASP3|CYCS|IL1B|MMP9|VEGFA | bacterial 30S ribosomal subunit inhibitor | Details | |
| C03423 | BRD-K89337853 | minodronic-acid | FDPS|GGPS1 | bone resorption inhibitor | Details | |
| C03424 | BRD-K06902185 | minoxidil | ABCC9|KCNJ1|KCNJ10|KCNJ11|KCNJ8|PTGS1 | KATP activator; Kir6 channel (KATP) activator; vasodilator | Details | |
| C03425 | BRD-K30764557 | miocamycin | other antibiotic | Details | ||
| C03426 | BRD-K39706510 | MIRA-1 | apoptosis stimulant | Details | ||
| C03427 | BRD-K47949423 | mirabegron | ADRB1|ADRB2|ADRB3 | adrenergic receptor agonist | Details | |
| C03428 | BRD-K55420858 | mirin | MRE11A | MRE11A exonuclease inhibitor | Details | |
| C03429 | BRD-M78068755 | miriplatin | DNA synthesis inhibitor | Details | ||
| C03430 | BRD-K82967685 | mirodenafil | PDE5A | phosphodiesterase inhibitor | Details | |
| C03431 | BRD-A64977602 | mirtazapine | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|DRD1|DRD2|DRD3|DRD5|HRH1|HRH3|HTR2A|HTR2B|HTR2C|HTR3A|HTR7|OPRK1|SLC6A2|SLC6A3|SLC6A4 | adrenergic receptor antagonist; serotonin receptor antagonist | Details | |
| C03432 | BRD-A16263897 | misonidazole | Details | |||
| C03433 | BRD-A72351335 | misoprostol | PTGER2|PTGER3|PTGER4|PTGIR | prostanoid receptor agonist | Details | |
| C03434 | BRD-K52959329 | mitiglinide | ABCC8|KCNJ10|PPARG | insulin secretagogue | Details | |
| C03435 | BRD-K35882976 | mitoflaxone | VWF | antitumor agent | Details | |
| C03436 | BRD-A48237631 | mitomycin-c | DNA alkylating agent; DNA synthesis inhibitor | Details | ||
| C03437 | BRD-A31204924 | mitotane | CYP11A1|CYP11B1|ESR1|FDX1 | antineoplastic agent | Details | |
| C03438 | BRD-K21680192 | mitoxantrone | TOP2A | topoisomerase inhibitor | Details | |
| C03439 | BRD-A48465967 | mivacurium | BCHE|CHRM2|CHRM3|CHRNA2 | acetylcholine receptor antagonist | Details | |
| C03440 | BRD-K39576764 | mivobulin | microtubule inhibitor | Details | ||
| C03441 | BRD-K21884483 | mizolastine | HRH1 | histamine receptor antagonist | Details | |
| C03442 | BRD-K88061624 | mizoribine | IMPDH1 | immunosuppressant; inosine monophosphate dehydrogenase inhibitor | Details | |
| C03443 | BRD-K71315565 | MJ-15 | CNR1 | cannabinoid receptor antagonist | Details | |
| C03444 | BRD-K91405252 | MK-0354 | HCAR2|HCAR3 | niacin receptor agonist | Details | |
| C03445 | BRD-K18850819 | MK-0752 | gamma secretase inhibitor | Details | ||
| C03446 | BRD-K38868394 | MK-0773 | AR | androgen receptor modulator | Details | |
| C03447 | BRD-K14175878 | MK-0812 | CCR2 | CC chemokine receptor antagonist | Details | |
| C03448 | BRD-K16732600 | MK-0893 | GCGR | glucagon receptor antagonist | Details | |
| C03449 | BRD-K54256913 | MK-1775 | WEE1 | WEE1 kinase inhibitor | Details | |
| C03450 | BRD-K03128512 | MK-2048 | HIV integrase inhibitor | Details | ||
| C03451 | BRD-K68065987 | MK-2206 | AKT1|AKT2|AKT3 | AKT inhibitor | Details | |
| C03452 | BRD-K43316319 | MK-2295 | TRPV1 | TRPV antagonist | Details | |
| C03453 | BRD-K56405753 | MK-2461 | FGFR1|FGFR2|FGFR3|FLT1|FLT3|FLT4|KDR|MERTK|MET|MST1R|NTRK1|NTRK2|PDGFRB | FGFR inhibitor; VEGFR inhibitor | Details | |
| C03454 | BRD-K27983781 | MK-2894 | PTGER4 | prostaglandin inhibitor | Details | |
| C03455 | BRD-K66911501 | MK-3207 | CALCA | calcitonin antagonist | Details | |
| C03456 | BRD-K95828359 | MK-3697 | HCRTR2 | orexin receptor antagonist | Details | |
| C03457 | BRD-K03886848 | MK-5046 | BRS3|GRPR|NMBR | bombesin receptor agonist | Details | |
| C03458 | BRD-K53665955 | MK-5108 | AURKA|AURKB|AURKC | Aurora kinase inhibitor | Details | |
| C03459 | BRD-A73679382 | MK-571 | ABCC2|CYSLTR1 | leukotriene receptor antagonist | Details | |
| C03460 | BRD-K03894385 | MK-6096 | HCRTR1|HCRTR2 | orexin receptor antagonist | Details | |
| C03461 | BRD-K55512740 | MK-8033 | MET | c-Met inhibitor | Details | |
| C03462 | BRD-K29656036 | MK-8245 | SCD | stearoyl-CoA desaturase inhibitor | Details | |
| C03463 | BRD-K25279140 | MK-8745 | AURKA | Aurora kinase inhibitor | Details | |
| C03464 | BRD-K61695967 | MKT-077 | HSP inhibitor | Details | ||
| C03465 | BRD-K90316462 | MK2-IN-1 | MAPKAPK2 | MAP kinase inhibitor | Details | |
| C03466 | BRD-K69343602 | ML-10302 | HTR3A|HTR3B|HTR4 | serotonin receptor partial agonist | Details | |
| C03467 | BRD-A28422330 | ML-141 | CDC42 | GTPase inhibitor | Details | |
| C03468 | BRD-K77547509 | ML-179 | NR5A2 | liver receptor homolog inverse agonist | Details | |
| C03469 | BRD-K27539181 | ML-193 | GPR55 | G protein-coupled receptor antagonist | Details | |
| C03470 | BRD-A12633378 | ML-213 | KCNQ4 | potassium channel activator | Details | |
| C03471 | BRD-K92995792 | ML-218 | CACNA1G|CACNA1H|CACNA1I | T-type calcium channel binder | Details | |
| C03472 | BRD-K44432556 | ML-228 | HIF1A | hypoxia inducible factor activator | Details | |
| C03473 | BRD-K60020910 | ML-277 | KCNQ1 | potassium channel activator | Details | |
| C03474 | BRD-K48188942 | ML-281 | STK33 | serine/threonine kinase inhibitor | Details | |
| C03475 | BRD-K51137250 | ML-297 | KCNJ3 | inward rectifier potassium channel activator | Details | |
| C03476 | BRD-K24600306 | ML-298 | PLD2 | phospholipase inhibitor | Details | |
| C03477 | BRD-K93942811 | ML-323 | USP1 | ubiquitin specific protease inhibitor | Details | |
| C03478 | BRD-A29014990 | ML-3403 | CYP3A4|MAPK11|MAPK12|MAPK14 | MAP kinase inhibitor | Details | |
| C03479 | BRD-K81044214 | ML-348 | LYPLA1 | lysophospholipase inhibitor | Details | |
| C03480 | BRD-K02160913 | ML-365 | KCNK3|KCNK9 | potassium channel blocker | Details | |
| C03481 | BRD-K52644305 | ML-786 | BRAF|RAF1 | RAF inhibitor | Details | |
| C03482 | BRD-K68402494 | ML-9 | TRPC6 | myosin light chain kinase inhibitor | Details | |
| C03483 | BRD-K83963101 | MLN-8054 | AURKA | Aurora kinase inhibitor | Details | |
| C03484 | BRD-K59317601 | MLN0128 | MTOR|PIK3CA|PIK3CD|PIK3CG | mTOR inhibitor | Details | |
| C03485 | BRD-K73877023 | MLN1117 | PIK3CA | PI3K inhibitor | Details | |
| C03486 | BRD-K43410529 | MLN2480 | RAF inhibitor | Details | ||
| C03487 | BRD-K15203492 | MLN9708 | proteasome inhibitor | Details | ||
| C03488 | BRD-K89306950 | ML130 | NOD1 inhibitor | Details | ||
| C03489 | BRD-K33743361 | ML133 | potassium channel blocker | Details | ||
| C03490 | BRD-K59036917 | ML161 | protease-activated receptor inhibitor | Details | ||
| C03491 | BRD-K64835161 | ML167 | CLK4|DYRK1B | CLK inhibitor; DYRK inhibitor | Details | |
| C03492 | BRD-K80021413 | ML204 | TRPC4|TRPC5 | transient receptor potential channel antagonist | Details | |
| C03493 | BRD-K92606079 | ML314 | NTSR1 | neurotensin agonist | Details | |
| C03494 | BRD-K25611237 | ML324 | KDM4A | histone lysine demethylase inhibitor | Details | |
| C03495 | BRD-K33892651 | ML347 | ACVR1|ACVRL1|BMPR1A | ALK tyrosine kinase receptor inhibitor | Details | |
| C03496 | BRD-K68474068 | MM-102 | WDR5/MLL interaction inhibitor | Details | ||
| C03497 | BRD-K98353094 | MM-11253 | RARG | retinoid receptor antagonist | Details | |
| C03498 | BRD-K56077740 | MMPX | phosphodiesterase inhibitor | Details | ||
| C03499 | BRD-K50293352 | MM77 | HTR1A | serotonin receptor antagonist | Details | |
| C03500 | BRD-K16183658 | MN-64 | TNKS | tankyrase inhibitor | Details |