CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C05701 | BRD-K19412342 | valspodar | ABCB1 | P glycoprotein inhibitor | Details | |
| C05702 | BRD-K91065602 | vancomycin | bacterial cell wall synthesis inhibitor | Details | ||
| C05703 | BRD-K77625799 | vandetanib | EGFR|EPHA1|EPHA10|EPHA2|EPHA3|EPHA4|EPHA5|EPHA6|EPHA7|EPHA8|EPHB1|EPHB2|EPHB3|EPHB4|EPHB6|ERBB2|ERBB3|ERBB4|FLT1|FLT4|KDR|PTK6|RET|SRC|TEK|VEGFA | EGFR inhibitor; RET tyrosine kinase inhibitor; VEGFR inhibitor | Details | |
| C05704 | BRD-K24258499 | vanillin | ABAT|ALDH5A1 | Details | ||
| C05705 | BRD-K33510429 | vanillylacetone | Details | |||
| C05706 | BRD-K26502378 | vanitiolide | Details | |||
| C05707 | BRD-K32501161 | vanoxerine | SLC6A3 | dopamine uptake inhibitor | Details | |
| C05708 | BRD-K13926615 | vardenafil | PDE5A|PDE6G|PDE6H | phosphodiesterase inhibitor | Details | |
| C05709 | BRD-A86216746 | varenicline | CHRNA3|CHRNA4|CHRNA6|CHRNA7 | acetylcholine receptor agonist | Details | |
| C05710 | BRD-K09711437 | varespladib | PLA2G2A | secretory phospholipase inhibitor | Details | |
| C05711 | BRD-K73028949 | vasopressin | AVPR1A|AVPR1B|AVPR2|OXTR | vasopressin receptor agonist | Details | |
| C05712 | BRD-K70163715 | vatalanib | EGFR|FLT1|FLT4|KDR|PDGFRB | KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor | Details | |
| C05713 | BRD-K36338614 | VBY-825 | CTSB|CTSL|CTSS | cathepsin inhibitor | Details | |
| C05714 | BRD-K75956464 | VCH-916 | HCV inhibitor | Details | ||
| C05715 | BRD-K26756394 | VE-821 | ATR | ATR kinase inhibitor | Details | |
| C05716 | BRD-K04701033 | VE-822 | ATM|ATR|MTOR|PIK3CG | ATR kinase inhibitor | Details | |
| C05717 | BRD-K20168442 | vecuronium | CHRNA2 | acetylcholine receptor antagonist | Details | |
| C05718 | BRD-K12852738 | veliflapon | ALOX5AP | leukotriene synthesis inhibitor | Details | |
| C05719 | BRD-K12737986 | veliparib | PARP1|PARP2 | PARP inhibitor | Details | |
| C05720 | BRD-K06357403 | velneperit | NPY5R | neuropeptide receptor antagonist | Details | |
| C05721 | BRD-K56343971 | vemurafenib | BRAF|RAF1 | RAF inhibitor | Details | |
| C05722 | BRD-K62391742 | venetoclax | BCL2 | BCL inhibitor | Details | |
| C05723 | BRD-A51714012 | venlafaxine | SLC6A2|SLC6A3|SLC6A4 | adrenergic inhibitor; norepinephrine reuptake inhibitor; serotonin norepinephrine reuptake inhibitor (SNRI) | Details | |
| C05724 | BRD-K32330832 | VER-155008 | HSPA1A | HSP inhibitor | Details | |
| C05725 | BRD-K38548312 | VER-49009 | HSP90AA1 | HSP inhibitor | Details | |
| C05726 | BRD-A09533288 | verapamil | CACNA1A|CACNA1B|CACNA1C|CACNA1D|CACNA1F|CACNA1G|CACNA1I|CACNA1S|CACNB1|CACNB2|CACNB3|CACNB4|CYP3A4|KCNA10|KCNA7|KCNH2|KCNJ11|NALCN|SCN5A|SLC29A4|SLC6A4 | calcium channel blocker | Details | |
| C05727 | BRD-K36201510 | verbascoside | PKC inhibitor; NFkB pathway inhibitor | Details | ||
| C05728 | BRD-K47929404 | vercirnon | CCR9 | CC chemokine receptor antagonist | Details | |
| C05729 | BRD-K36741660 | verinurad | SLC22A12 | urate transporter inhibitor | Details | |
| C05730 | BRD-K19741547 | vernakalant | KCNA5 | potassium channel blocker | Details | |
| C05731 | BRD-K81849500 | verteporfin | photosensitizing agent | Details | ||
| C05732 | BRD-K42673188 | verubulin | TUBB | tubulin polymerization inhibitor | Details | |
| C05733 | BRD-K14765469 | vesamicol | SLC18A3 | acetylcholinesterase inhibitor | Details | |
| C05734 | BRD-K13414800 | vesnarinone | KCNH2|PDE3A | phosphodiesterase inhibitor | Details | |
| C05735 | BRD-A32269193 | VGX-1027 | TLR4 | tumor necrosis factor receptor antagonist | Details | |
| C05736 | BRD-K84748119 | vicriviroc | CCR5 | CC chemokine receptor antagonist | Details | |
| C05737 | BRD-K72093121 | vidarabine | ADA | antiviral | Details | |
| C05738 | BRD-A07893380 | vigabatrin | ABAT|GABBR1|SLC32A1 | GABA aminotransferase inhibitor | Details | |
| C05739 | BRD-M36487418 | vilanterol | ADRB2 | adrenergic receptor agonist | Details | |
| C05740 | BRD-K58010567 | vilazodone | DRD2|DRD3|HRH1|HTR1A|HTR4|SLC6A4 | serotonin reuptake inhibitor | Details | |
| C05741 | BRD-A94993966 | vildagliptin | DPP4 | dipeptidyl peptidase inhibitor | Details | |
| C05742 | BRD-A59198242 | viloxazine | SLC6A2 | norepinephrine reuptake inhibitor | Details | |
| C05743 | BRD-K06519765 | vinblastine | JUN|TUBA1A|TUBB|TUBD1|TUBE1|TUBG1 | microtubule inhibitor; tubulin polymerization inhibitor | Details | |
| C05744 | BRD-K40227168 | vinburnine | CHRM1|CHRM2|CHRM3|CHRM4 | adrenergic receptor antagonist | Details | |
| C05745 | BRD-K89704198 | vincamine | CHRM1|CHRM2|CHRM3|CHRM4 | adrenergic receptor antagonist | Details | |
| C05746 | BRD-K12251893 | vincristine | TUBA4A|TUBB | tubulin polymerization inhibitor | Details | |
| C05747 | BRD-K59753975 | vindesine | TUBB|TUBB1 | tubulin polymerization inhibitor | Details | |
| C05748 | BRD-K64120610 | vinflunine | microtubule inhibitor | Details | ||
| C05749 | BRD-K04269837 | vinorelbine | TUBA1A|TUBA1B|TUBA1C|TUBA3C|TUBA3D|TUBA3E|TUBA4A|TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8 | tubulin polymerization inhibitor | Details | |
| C05750 | BRD-K53318339 | vinpocetine | PDE1A|PDE1C | phosphodiesterase inhibitor; sodium channel blocker | Details | |
| C05751 | BRD-A42379279 | viomycin | protein synthesis inhibitor | Details | ||
| C05752 | BRD-K56565215 | vipadenant | ADORA1|ADORA2A|ADORA2B|ADORA3 | adenosine receptor antagonist | Details | |
| C05753 | BRD-K44827188 | vismodegib | SMO | hedgehog pathway inhibitor; smoothened receptor antagonist | Details | |
| C05754 | BRD-A75369945 | vitamin-b12 | Details | |||
| C05755 | BRD-K97091514 | vitamin-E | ALOX5|DGKA|NR1I2|PPP2CA|PPP2CB|PRKCA|PRKCB|SEC14L2|SEC14L3|SEC14L4 | PKC inhibitor; LDL oxidation inhibitor | Details | |
| C05756 | BRD-K26122255 | VLX-600 | TP53 | antitumor agent | Details | |
| C05757 | BRD-K89053832 | VLX600 | USP14 | ubiquitin C-terminal hydrolase inhibitor | Details | |
| C05758 | BRD-K66850609 | voglibose | MGAM | glucosidase inhibitor | Details | |
| C05759 | BRD-K69776681 | volasertib | PLK1 | PLK inhibitor | Details | |
| C05760 | BRD-K23647661 | volinanserin | HTR2A|HTR2B|HTR2C|KCNH2 | serotonin receptor antagonist | Details | |
| C05761 | BRD-K32768103 | vonoprazan | ATP4A | potassium-competitive acid antagonist | Details | |
| C05762 | BRD-K93442924 | vorapaxar | F2R | thrombin receptor antagonist | Details | |
| C05763 | BRD-K23677682 | voreloxin | TOP2A | topoisomerase inhibitor | Details | |
| C05764 | BRD-K06557128 | voriconazole | CYP2C19|CYP2C9|CYP3A4|CYP3A5|PTGS1 | cytochrome P450 inhibitor | Details | |
| C05765 | BRD-K81418486 | vorinostat | HDAC1|HDAC10|HDAC11|HDAC2|HDAC3|HDAC5|HDAC6|HDAC8|HDAC9 | HDAC inhibitor | Details | |
| C05766 | BRD-K53963539 | vortioxetine | HTR1A|HTR1B|HTR2A|HTR2C|HTR3A|HTR5A|HTR6|HTR7|SLC6A4 | serotonin receptor agonist; serotonin receptor antagonist | Details | |
| C05767 | BRD-K56291712 | voxtalisib | MTOR|PIK3CA | mTOR inhibitor; PI3K inhibitor | Details | |
| C05768 | BRD-K21071223 | VP-20629 | PLA2G2E|SLC36A1 | beta amyloid antagonist | Details | |
| C05769 | BRD-K09877029 | VS-4718 | focal adhesion kinase inhibitor | Details | ||
| C05770 | BRD-K72005722 | VT-464 | CYP17A1 | cytochrome P450 inhibitor | Details | |
| C05771 | BRD-K81694556 | VTP-27999 | REN | renin inhibitor | Details | |
| C05772 | BRD-K27074404 | VU-0240551 | SLC12A5 | potassium/chloride cotransporter inhibitor | Details | |
| C05773 | BRD-K93317811 | VU-0364739 | PLD2 | phospholipase inhibitor | Details | |
| C05774 | BRD-K68674163 | VU-0422288 | GRM3 | glutamate receptor allosteric modulator | Details | |
| C05775 | BRD-K87727457 | VU-152100 | CHRM4 | acetylcholine receptor allosteric modulator | Details | |
| C05776 | BRD-K11046126 | VUF10166 | HTR3A|HTR3B | serotonin receptor antagonist | Details | |
| C05777 | BRD-K90082312 | VUF10460 | HRH4 | histamine receptor agonist | Details | |
| C05778 | BRD-A93717708 | VUF11207 | ACKR3 | CC chemokine receptor agonist | Details | |
| C05779 | BRD-K48535733 | VU0155069 | PLD1 | phospholipase inhibitor | Details | |
| C05780 | BRD-K24187789 | VU0238429 | CHRM5 | acetylcholine receptor allosteric modulator | Details | |
| C05781 | BRD-K86109159 | VU0357121 | GRM5 | glutamate receptor positive allosteric modulator | Details | |
| C05782 | BRD-K83649660 | VU0360172 | GRM5 | glutamate receptor positive allosteric modulator | Details | |
| C05783 | BRD-K45462423 | VU0361737 | GRM4 | glutamate receptor positive allosteric modulator | Details | |
| C05784 | BRD-K72687424 | VU0364439 | GRM4 | glutamate receptor positive allosteric modulator | Details | |
| C05785 | BRD-K66527818 | VU0364770 | GRM4 | glutamate receptor positive allosteric modulator | Details | |
| C05786 | BRD-K12483104 | VU10010 | CHRM4 | acetylcholine receptor allosteric modulator | Details | |
| C05787 | BRD-K48371964 | VU1545 | GRM5 | glutamate receptor positive allosteric modulator | Details | |
| C05788 | BRD-K54783522 | VU29 | GRM5 | glutamate receptor potentiator | Details | |
| C05789 | BRD-K72063794 | VU591 | KCNJ1 | potassium channel blocker | Details | |
| C05790 | BRD-K93725829 | VX-11e | MAPK1 | MAP kinase inhibitor | Details | |
| C05791 | BRD-K70610771 | VX-222 | HCV inhibitor | Details | ||
| C05792 | BRD-K07736136 | VX-702 | MAPK11|MAPK12|MAPK14 | p38 MAPK inhibitor | Details | |
| C05793 | BRD-K91900765 | VX-745 | MAPK11|MAPK12|MAPK14 | p38 MAPK inhibitor | Details | |
| C05794 | BRD-K26712974 | VX-765 | CASP1 | caspase inhibitor | Details | |
| C05795 | BRD-A00559310 | W-54011 | C5AR1 | anaphylatoxin chemotactic receptor antagonist | Details | |
| C05796 | BRD-K01129913 | walrycin-b | transcriptional regulatory protein WalR | Details | ||
| C05797 | BRD-A24514565 | warfarin | VKORC1 | vitamin K antagonist | Details | |
| C05798 | BRD-K69812556 | WAY-100635 | HTR1A | serotonin receptor antagonist | Details | |
| C05799 | BRD-A62021152 | WAY-161503 | HTR2C | serotonin receptor agonist | Details | |
| C05800 | BRD-K36198571 | WAY-170523 | MMP13 | metalloproteinase inhibitor | Details |