CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

CMap Candidates

CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.

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Associated NAFLD Targets:

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6125 records.

CMap ID	Pert ID	Compound Name	Targets	MoA
C02101	BRD-K14590126	farnesyl-thiosalicylic-acid-amide	HRAS	Ras GTPase inhibitor	Details
C02102	BRD-A49622760	faropenem		lactamase inhibitor	Details
C02103	BRD-K59045783	faropenem-medoxomil		lactamase inhibitor	Details
C02104	BRD-K76617868	fasudil	PKIA\|PRKACA\|ROCK1\|ROCK2	rho associated kinase inhibitor	Details
C02105	BRD-K04264130	favipiravir		RNA polymerase inhibitor	Details
C02106	BRD-A10991937	FCE-22250		DNA directed DNA polymerase inhibitor	Details
C02107	BRD-K18157228	fdcyd		DNA methyltransferase inhibitor	Details
C02108	BRD-K48367671	febuxostat	XDH	xanthine oxidase inhibitor	Details
C02109	BRD-K99107520	felbamate	GRIN1\|GRIN2A\|GRIN2B\|GRIN2C\|GRIN2D\|GRIN3A\|GRIN3B	glutamate receptor antagonist	Details
C02110	BRD-K91740057	felbinac	CTSL	cyclooxygenase inhibitor	Details
C02111	BRD-K26404903	felbinac-ethyl	PTGS1\|PTGS2	cyclooxygenase inhibitor	Details
C02112	BRD-A30815329	felodipine	CACNA1C\|CACNA1D\|CACNA1F\|CACNA1H\|CACNA1S\|CACNA2D1\|CACNA2D2\|CACNB2\|CALM1\|CFTR\|NR3C2\|PDE1A\|PDE1B\|TNNC1\|TNNC2	calcium channel blocker	Details
C02113	BRD-K08791496	fenaclon			Details
C02114	BRD-K51318897	fenbendazole	TUBB	tubulin polymerization inhibitor	Details
C02115	BRD-K12513978	fenbufen	PTGS1\|PTGS2	cyclooxygenase inhibitor	Details
C02116	BRD-A81615860	fenclonine-(+/-)	PAH\|TPH1\|TPH2	tryptophan hydroxylase inhibitor	Details
C02117	BRD-A71033472	fendiline	HTR2B	calcium channel blocker	Details
C02118	BRD-A66920069	fenigam	GABBR1\|GABBR2	benzodiazepine receptor agonist	Details
C02119	BRD-A66284731	fenipentol		choleretic agent	Details
C02120	BRD-K41160163	fenobam	GRM5	glutamate receptor antagonist	Details
C02121	BRD-K50388907	fenofibrate	MMP25\|PPARA	PPAR receptor agonist	Details
C02122	BRD-K30213273	fenofibric-acid	CLCN1\|PPARA	cytochrome P450 inhibitor	Details
C02123	BRD-A50684349	fenoldopam	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C\|DRD1\|DRD4\|DRD5	dopamine receptor agonist	Details
C02124	BRD-A81129465	fenoprofen	PTGS1\|PTGS2\|SLC5A8	prostaglandin inhibitor	Details
C02125	BRD-A97104540	fenoterol	ADRB1\|ADRB2\|ADRB3	adrenergic receptor agonist	Details
C02126	BRD-K77564118	fenoverine		acetylcholine receptor antagonist	Details
C02127	BRD-K44777569	fenoxaprop-p-ethyl	NOS2\|NOS3		Details
C02128	BRD-K89085489	fenretinide	RARA	apoptosis stimulant; retinoid receptor agonist	Details
C02129	BRD-K26739552	fenspiride		bronchodilator	Details
C02130	BRD-K67217586	fenthion		cholinesterase inhibitor	Details
C02131	BRD-K16077845	fentiazac	PTGS1\|PTGS2	cyclooxygenase inhibitor	Details
C02132	BRD-A33697453	fenticonazole		bacterial cell wall synthesis inhibitor	Details
C02133	BRD-K61642990	FERb-033	ERBB2	EGFR inhibitor	Details
C02134	BRD-K97375133	ferrostatin-1		ferroptosis inhibitor	Details
C02135	BRD-K66295376	ferulic-acid	CA1\|CA12\|CA14\|CA2\|CA4\|CA6\|CA9	antioxidant	Details
C02136	BRD-K46731503	fesoterodine	CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5	acetylcholine receptor antagonist	Details
C02137	BRD-K08864679	fexaramine	NR1H4	FXR agonist	Details
C02138	BRD-K37069697	fexinidazole			Details
C02139	BRD-A73368467	fexofenadine	HRH1	histamine receptor antagonist	Details
C02140	BRD-K56807945	FG-2216	EGLN1\|EGLN2\|HIF1A	hypoxia inducible factor prolyl hydroxylase inhibitor	Details
C02141	BRD-K14385366	FG-4592	EGLN2	hypoxia inducible factor prolyl hydroxylase inhibitor	Details
C02142	BRD-K61951118	FG-7142		GABA benzodiazepine site receptor inverse agonist	Details
C02143	BRD-K09778810	FGIN-1-27	TSPO	inositol monophosphatase inhibitor	Details
C02144	BRD-K66093087	FGIN-1-43	TSPO	benzodiazepine receptor agonist	Details
C02145	BRD-K48112880	FH-535	PPARD\|PPARG	PPAR receptor antagonist; WNT signaling inhibitor	Details
C02146	BRD-K44777625	FH1		hepatocyte function enhancer	Details
C02147	BRD-K07160047	fiacitabine		DNA synthesis inhibitor	Details
C02148	BRD-A63752151	fidarestat	AKR1B1	aldose reductase inhibitor	Details
C02149	BRD-K57371763	fidaxomicin		RNA polymerase inhibitor	Details
C02150	BRD-K37379014	filanesib	KIF11	kinesin inhibitor; kinesin-like spindle protein inhibitor	Details
C02151	BRD-K16803204	filgotinib	JAK1\|JAK2\|JAK3\|TYK2	JAK inhibitor	Details
C02152	BRD-K21586122	fimasartan	AGTR1	angiotensin receptor antagonist	Details
C02153	BRD-K98384930	finafloxacin		bacterial DNA gyrase inhibitor	Details
C02154	BRD-K01095011	finasteride	AKR1D1\|SRD5A1\|SRD5A2	5 alpha reductase inhibitor	Details
C02155	BRD-K88025533	fingolimod	S1PR1\|S1PR5	immunosuppressant; sphingosine phosphate receptor agonist	Details
C02156	BRD-K37688416	fipexide		psychoactive drug	Details
C02157	BRD-K61560897	FIPI	PLD1\|PLD2	phospholipase inhibitor	Details
C02158	BRD-A50675702	fipronil		chloride channel blocker; GABA gated chloride channel blocker	Details
C02159	BRD-K17513304	firategrast	ITGA4	integrin antagonist	Details
C02160	BRD-K09090523	firocoxib	PTGS2	cyclooxygenase inhibitor	Details
C02161	BRD-K31836715	fisetin	CDK6\|FASN	Aurora kinase inhibitor	Details
C02162	BRD-K17896185	FIT	OPRD1	opioid receptor agonist	Details
C02163	BRD-A01907367	FK-33-824	OPRM1	opioid receptor agonist	Details
C02164	BRD-K38350380	FK-3311	PTGS2	cyclooxygenase inhibitor	Details
C02165	BRD-K58550667	FK-866	NAMPT	niacinamide phosphoribosyltransferase inhibitor	Details
C02166	BRD-K83508485	FK-888	TACR1\|TACR2	tachykinin antagonist	Details
C02167	BRD-K80607346	FK-962		somatostatin receptor agonist	Details
C02168	BRD-A86545589	flavin-adenine-dinucleotide	ACAD8\|ACADM\|ACADS\|ACOX1\|AIFM1\|CYB5R1\|CYB5R3\|DAO\|DLD\|DPYD\|ERO1LB\|FDXR\|GCDH\|GFER\|GSR\|IL4I1\|IVD\|MAOA\|MAOB\|NOS1\|NQO1\|NQO2\|POR\|TXNRD1\|XDH		Details
C02169	BRD-K47639036	flavoxate	CHRM1\|CHRM2	acetylcholine receptor antagonist	Details
C02170	BRD-A09472452	flecainide	KCNA5\|KCNA7\|SCN4A\|SCN5A	sodium channel blocker	Details
C02171	BRD-K61717546	fleroxacin		topoisomerase inhibitor	Details
C02172	BRD-A44500574	FLI-06		notch signaling inhibitor	Details
C02173	BRD-K33637378	flibanserin	DRD4\|HTR1A\|HTR2A	serotonin receptor agonist	Details
C02174	BRD-K56740996	flindokalner	KCNMA1\|KCNN4\|KCNQ2\|KCNQ4\|KCNQ5	potassium channel agonist	Details
C02175	BRD-A23418262	floctafenine	PTGS1\|PTGS2	cyclooxygenase inhibitor	Details
C02176	BRD-K43383936	flopropione	HTR1A	serotonin receptor antagonist	Details
C02177	BRD-A30886737	florfenicol		protein synthesis inhibitor	Details
C02178	BRD-A79643124	flosequinan		phosphodiesterase inhibitor	Details
C02179	BRD-A03757454	floxuridine	TYMS	DNA synthesis inhibitor	Details
C02180	BRD-K86003836	flubendazole	TUBB	tubulin polymerization inhibitor	Details
C02181	BRD-K27871792	flucloxacillin		bacterial cell wall synthesis inhibitor	Details
C02182	BRD-K05977355	fluconazole	CYP51A1	sterol demethylase inhibitor	Details
C02183	BRD-K82143716	flucytosine	DNMT1	other antifungal	Details
C02184	BRD-K66788707	fludarabine	ADA\|RRM1\|RRM2	ribonucleotide reductase inhibitor	Details
C02185	BRD-K71106091	fludarabine-phosphate	DCK\|POLA1\|POLD1\|POLE\|RRM1\|RRM2\|RRM2B	ribonucleotide reductase inhibitor	Details
C02186	BRD-K06408664	fludrocortisone-acetate	AR\|NR3C1\|NR3C2		Details
C02187	BRD-A49765801	fludroxycortide	NR3C1\|SERPINA6	glucocorticoid receptor agonist	Details
C02188	BRD-K44067360	flufenamic-acid	AKR1C3\|ANO1\|AR\|GJA1\|GJA10\|GJA3\|GJA4\|GJA5\|GJA8\|GJA9\|GJB1\|GJB2\|GJB3\|GJB4\|GJB5\|GJB6\|GJB7\|GJC1\|GJC2\|GJC3\|GJD2\|GJD3\|GJD4\|GJE1\|PANX1\|PANX2\|PANX3\|PKD2L1\|PTGS1\|PTGS2\|TRPC5\|TRPM2\|TRPM5	chloride channel blocker	Details
C02189	BRD-K68870568	flumatinib	ABL1\|PDGFRB	Bcr-Abl kinase inhibitor	Details
C02190	BRD-K98769987	flumazenil	GABRA1\|GABRA2\|GABRA3\|GABRA4\|GABRA5\|GABRA6\|GABRB1\|GABRB2\|GABRB3\|GABRD\|GABRE\|GABRG1\|GABRG2\|GABRG3\|GABRP\|GABRQ	benzodiazepine receptor antagonist	Details
C02191	BRD-A44181516	flumecinol			Details
C02192	BRD-A69777949	flumequine		topoisomerase inhibitor	Details
C02193	BRD-K61496577	flumethasone	NR3C1\|PLA2G1B	glucocorticoid receptor agonist	Details
C02194	BRD-A50064262	flumethasone-pivalate	NR3C1\|SERPINA6	glucocorticoid receptor agonist	Details
C02195	BRD-A43518428	flumexadol			Details
C02196	BRD-K29582677	flunarizine	CACNA1G\|CACNA1H\|CACNA1I\|CALM1\|HRH1	calcium channel blocker	Details
C02197	BRD-A65449987	flunisolide	NR3C1	cytochrome P450 inhibitor	Details
C02198	BRD-K99984802	flunixin-meglumin		prostanoid receptor antagonist	Details
C02199	BRD-K94353609	fluocinolone-acetonide	NR3C1\|SERPINA6	glucocorticoid receptor agonist	Details
C02200	BRD-K57886322	fluocinonide	NR3C1\|SERPINA6\|SMO	glucocorticoid receptor agonist	Details