CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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6125 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C03001 | BRD-K06593056 | LE-135 | RARB | retinoid receptor agonist | Details | |
| C03002 | BRD-K05446112 | ledipasvir | HCV inhibitor | Details | ||
| C03003 | BRD-K78692225 | leflunomide | AHR|DHODH|PTK2B | dihydroorotate dehydrogenase inhibitor; PDGFR tyrosine kinase receptor inhibitor | Details | |
| C03004 | BRD-K78666663 | lemborexant | HCRTR1|HCRTR2 | orexin receptor antagonist | Details | |
| C03005 | BRD-A17883755 | lenalidomide | CDH5|CRBN|PTGS2|TNF|TNFSF11 | anticancer agent | Details | |
| C03006 | BRD-K39974922 | lenvatinib | FLT4|KDR | FGFR inhibitor; KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor | Details | |
| C03007 | BRD-A18992208 | lercanidipine | CACNA2D1|CACNG1 | calcium channel blocker | Details | |
| C03008 | BRD-K62398570 | lerisetron | HTR3A | serotonin receptor antagonist | Details | |
| C03009 | BRD-K03289534 | lersivirine | non-nucleoside reverse transcriptase inhibitor | Details | ||
| C03010 | BRD-K75024268 | lesinurad | SLC22A12 | uric acid diuretic | Details | |
| C03011 | BRD-A27376179 | lestaurtinib | FLT3|NTRK1 | FLT3 inhibitor; growth factor receptor inhibitor; JAK inhibitor | Details | |
| C03012 | BRD-K21612934 | leteprinim | nerve growth factor agonist | Details | ||
| C03013 | BRD-K94288301 | letermovir | CMV terminase inhibitor | Details | ||
| C03014 | BRD-A32597168 | letosteine | mucolytic agent | Details | ||
| C03015 | BRD-K88789588 | letrozole | CYP19A1 | aromatase inhibitor | Details | |
| C03016 | BRD-K27460187 | leucomethylene-blue | MAPT | nitric oxide production inhibitor; tau aggregation inhibitor | Details | |
| C03017 | BRD-A75919782 | leucovorin | TYMS | folate receptor ligand | Details | |
| C03018 | BRD-K81136890 | leucylleucine-methyl-ester | Details | |||
| C03019 | BRD-K26323068 | leuprolide | GNRHR | gonadotropin releasing factor hormone receptor agonist | Details | |
| C03020 | BRD-K34469523 | levalbuterol | ADRB2 | adrenergic receptor agonist | Details | |
| C03021 | BRD-K30634073 | levallorphan | CHRNA2|OPRM1 | opioid antagonist | Details | |
| C03022 | BRD-K73107279 | levamisole | ALPL|ALPPL2|CHRNA3 | acetylcholine receptor agonist | Details | |
| C03023 | BRD-K24526313 | levcromakalim | KCNJ5 | potassium channel activator | Details | |
| C03024 | BRD-K49404994 | levetiracetam | CACNA1B|SCN1A|SV2A | calcium channel blocker | Details | |
| C03025 | BRD-A64698388 | levo-phencynonate | CHRM1 | acetylcholine receptor antagonist | Details | |
| C03026 | BRD-K43883465 | levobetaxolol | ADRB1|ADRB2 | adrenergic receptor antagonist | Details | |
| C03027 | BRD-K31812033 | levobunolol | ADRB1|ADRB2|ADRB3 | adrenergic receptor antagonist | Details | |
| C03028 | BRD-K73323637 | levobunolol-(+) | adrenergic receptor antagonist | Details | ||
| C03029 | BRD-A46876182 | levobunolol-(+/-) | adrenergic receptor antagonist | Details | ||
| C03030 | BRD-K33453211 | levocabastine | HRH1|NTSR2 | histamine receptor antagonist | Details | |
| C03031 | BRD-K59647213 | levocarnitine | Details | |||
| C03032 | BRD-K84366268 | levocarnitine-propionate | CRAT | carnitine palmitoyltransferase inhibitor | Details | |
| C03033 | BRD-K27184429 | levocetirizine | HRH1 | histamine receptor antagonist | Details | |
| C03034 | BRD-K34730807 | levodopa | DRD1|DRD2|DRD3|DRD4|DRD5|GPR143 | dopamine precursor | Details | |
| C03035 | BRD-K83551379 | levodropropizine | antitussive | Details | ||
| C03036 | BRD-K09471561 | levofloxacin | TOP2A | bacterial DNA gyrase inhibitor | Details | |
| C03037 | BRD-K62751771 | levomenol | Details | |||
| C03038 | BRD-K50329370 | levomenthol | OPRK1|TRPA1|TRPM8|TRPV3 | Details | ||
| C03039 | BRD-K35559145 | levomepromazine | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HTR2A|HTR2C | dopamine receptor antagonist | Details | |
| C03040 | BRD-A67616246 | levomequitazine | HRH1 | histamine receptor antagonist | Details | |
| C03041 | BRD-K02976377 | levonordefrin | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|SLC6A2 | vasodilator | Details | |
| C03042 | BRD-K35189033 | levonorgestrel | AR|ESR1|PGR|SRD5A1 | estrogen receptor agonist; glucocorticoid receptor antagonist; progesterone receptor agonist; progesterone receptor antagonist | Details | |
| C03043 | BRD-A54635441 | levopropoxyphene | OPRD1|OPRK1|OPRM1 | antitussive | Details | |
| C03044 | BRD-K03095347 | levosimendan | KCNJ11|KCNJ8|PDE3A|TNNC1 | calcium sensitizer | Details | |
| C03045 | BRD-K51671335 | levosulpiride | CA1|CA12|CA7|DRD2|DRD3 | dopamine receptor antagonist | Details | |
| C03046 | BRD-K30685142 | levothyroxine | THRA|THRB | thyroid hormone stimulant | Details | |
| C03047 | BRD-A30655177 | LFM-A13 | BTK | Bruton's tyrosine kinase (BTK) inhibitor | Details | |
| C03048 | BRD-K16810791 | LGK-974 | PORCN | porcupine inhibitor | Details | |
| C03049 | BRD-A56085258 | LGX818 | BRAF | RAF inhibitor | Details | |
| C03050 | BRD-K47409078 | LH846 | CSNK1D | casein kinase inhibitor | Details | |
| C03051 | BRD-A57133765 | liarozole | CYP19A1|CYP26A1 | cytochrome P450 inhibitor | Details | |
| C03052 | BRD-A22642447 | licarbazepine | SCN5A | voltage-gated sodium channel blocker | Details | |
| C03053 | BRD-K26011976 | licochalcone-a | PTPN1 | topoisomerase inhibitor | Details | |
| C03054 | BRD-K08439945 | licofelone | ALOX5|PLA2G2E|PTGS2 | cyclooxygenase inhibitor; lipoxygenase inhibitor | Details | |
| C03055 | BRD-K68693535 | lidamidine | adrenergic receptor agonist | Details | ||
| C03056 | BRD-K52662033 | lidocaine | EGFR|SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A | histamine receptor agonist | Details | |
| C03057 | BRD-K62996583 | lidoflazine | SCN1A|SCN3A|SLC29A1 | calcium channel blocker | Details | |
| C03058 | BRD-K48875051 | ligustilide | TNF | tumor necrosis factor production inhibitor | Details | |
| C03059 | BRD-K25015158 | limaprost-alfadex | PTGER1 | prostanoid receptor agonist | Details | |
| C03060 | BRD-K75373031 | LIMKi-3 | LIMK1 | LIM kinase inhibitor | Details | |
| C03061 | BRD-K05906022 | limonin | HIV protease inhibitor | Details | ||
| C03062 | BRD-A55468767 | linaclotide | GUCY2C | guanylate cyclase activator | Details | |
| C03063 | BRD-K96550715 | linagliptin | DPP4 | dipeptidyl peptidase inhibitor | Details | |
| C03064 | BRD-A43082461 | linalool | anticonvulsant | Details | ||
| C03065 | BRD-K81447180 | lincomycin | bacterial 30S ribosomal subunit inhibitor | Details | ||
| C03066 | BRD-K93814253 | lindane | GABRB1|GLRA1|GLRA2|GLRA3|GLRB | Details | ||
| C03067 | BRD-K66876909 | linezolid | MAOA|MAOB | bacterial 50S ribosomal subunit inhibitor | Details | |
| C03068 | BRD-K99749624 | linifanib | CSF1|CSF1R|FLT1|FLT3|FLT4|KDR|KIT|PDGFRB|RET|TEK | PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor | Details | |
| C03069 | BRD-K08973992 | linoleic-acid | FABP4|FFAR1|FFAR4|HNF4A|KCNB1|PPARG|TRPM8 | oxidative stress inducer | Details | |
| C03070 | BRD-K59332007 | linopirdine | KCNQ2|KCNQ3|KCNQ4|KCNQ5 | potassium channel blocker | Details | |
| C03071 | BRD-K86344238 | linsidomine | nitric oxide donor | Details | ||
| C03072 | BRD-K86118762 | linsitinib | IGF1R|INSR|INSRR | IGF-1 inhibitor | Details | |
| C03073 | BRD-K89152108 | liothyronine | THRA|THRB | thyroid hormone stimulant | Details | |
| C03074 | BRD-K46428823 | liothyronine-(isomer) | Details | |||
| C03075 | BRD-A14440173 | lipoamide | Details | |||
| C03076 | BRD-A48274390 | liraglutide | GLP1R | GLP receptor agonist | Details | |
| C03077 | BRD-K35775715 | liranaftate | fungal squalene epoxidase inhibitor | Details | ||
| C03078 | BRD-K31339321 | lirimilast | phosphodiesterase inhibitor | Details | ||
| C03079 | BRD-A76533773 | lisadimate | topical sunscreen agent | Details | ||
| C03080 | BRD-K67966701 | lisinopril | ACE|ACE2 | angiotensin converting enzyme inhibitor | Details | |
| C03081 | BRD-A05334458 | lisofylline | interleukin receptor antagonist; STAT inhibitor | Details | ||
| C03082 | BRD-K67943528 | lisuride | ADRA1A|ADRA2A|ADRA2B|ADRA2C|DRD1|DRD2|DRD3|DRD4|DRD5|HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C|HTR6 | dopamine receptor agonist | Details | |
| C03083 | BRD-K73234506 | lithium-acetoacetate | Details | |||
| C03084 | BRD-M41245765 | lithium-citrate | Details | |||
| C03085 | BRD-K04497194 | lithocholic-acid | GPBAR1|NR1H4|NR1I2|VDR | FXR antagonist; vitamin D receptor agonist | Details | |
| C03086 | BRD-K83029223 | litronesib | KIF11 | kinesin-like spindle protein inhibitor | Details | |
| C03087 | BRD-K59391348 | lixivaptan | AVPR2 | vasopressin receptor antagonist | Details | |
| C03088 | BRD-K70404782 | LM-22A4 | NTRK2 | tropomyosin receptor kinase inhibitor | Details | |
| C03089 | BRD-K08532119 | LMI070 | SMN1 | survival motor neuron protein modulator | Details | |
| C03090 | BRD-K49921286 | LMK-235 | HDAC4|HDAC5 | HDAC inhibitor | Details | |
| C03091 | BRD-A04649065 | LM11A-31 | NGFR | neurotrophic agent | Details | |
| C03092 | BRD-K66206289 | lobeline | CHRNA10|CHRNA9|SLC18A2 | acetylcholine receptor antagonist | Details | |
| C03093 | BRD-K15834839 | lobendazole | anthelmintic agent | Details | ||
| C03094 | BRD-K55847762 | lobenzarit | immunosuppressant | Details | ||
| C03095 | BRD-K66937583 | lodoxamide | histamine receptor antagonist | Details | ||
| C03096 | BRD-K06388517 | lofemizole | cyclooxygenase inhibitor | Details | ||
| C03097 | BRD-K82147103 | lofepramine | HTR1A|SLC6A2|SLC6A4 | norepinephrine reuptake inhibitor; serotonin norepinephrine reuptake inhibitor (SNRI) | Details | |
| C03098 | BRD-A02990301 | lofexidine | ADRA2A | adrenergic receptor agonist | Details | |
| C03099 | BRD-A75850590 | lomefloxacin | TOP2A | bacterial DNA gyrase inhibitor | Details | |
| C03100 | BRD-K27955832 | lomeguatrib | MGMT | O6-alkylguanine-DNA alkyltransferase inhibitor | Details |